Wenjun Wang
Resume
PhD candidate, Department of Pathology and Biomedical science, University Medical Center Groningen (UMCG), University of Groningen, The Netherlands, 2025 –
Research assistant, Key Laboratory of Embryonic Stem Cell Research Institute, Hubei university of Medicine, Hubei, China, 2024-2025
Master of Science, Pharmaceutical Analysis, Technology and Biopharmaceuticals, King’s College London, England, 2023-2024
Bachelor of Engineering, Biopharmaceuticals, Jinan University, Guangzhou, China, 2019-2023
Research
My project aims to elucidate mechanisms that impair alveolar regeneration in chronic obstructive pulmonary disease (COPD), focusing on the crosstalk between lung mesenchymal stromal cells (L-MSCs) and macrophages. We analyze COPD-specific alterations in epithelial regenerative ability under different L-MSC function and macrophage polarization status, using 3D alveolar organoid co-culture systems. Molecular profiling, including RNA-sequencing, ELISA, and surfactant staining, will identify the mechanisms underlying the epithelial proliferation and stromal-immune interactions, indicating potential therapeutic strategies for COPD alleviation.
Keywords: COPD, organoid, L-MSC, Macrophage
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