Publications

Below a list of publications found on Pubmed where members of our group where (co)author on:

  • Fan, Y, Moser, J, van Meurs, M, Kiers, D, Sand, JMB, Leeming, DJ et al.. Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study. Crit Care. 2024;28 (1):120. doi: 10.1186/s13054-024-04904-4. PubMed PMID:38609959 PubMed Central PMC11010428.
  • Jiménez-Gracia, L, Marchese, D, Nieto, JC, Caratù, G, Melón-Ardanaz, E, Gudiño, V et al.. FixNCut: single-cell genomics through reversible tissue fixation and dissociation. Genome Biol. 2024;25 (1):81. doi: 10.1186/s13059-024-03219-5. PubMed PMID:38553769 PubMed Central PMC10979608.
  • Visser, N, Herreman, LCM, Vandooren, J, Pereira, RVS, Opdenakker, G, Spelbrink, REJ et al.. Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage. J Mol Med (Berl). 2024;102 (4):521-536. doi: 10.1007/s00109-024-02423-x. PubMed PMID:38381158 PubMed Central PMC10963447.
  • Gay, ACA, Banchero, M, Carpaij, O, Kole, TM, Apperloo, L, van Gosliga, D et al.. Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma. Thorax. 2024; :. doi: 10.1136/thorax-2023-220230. PubMed PMID:38373824 .
  • Nizamoglu, M, Alleblas, F, Koster, T, Borghuis, T, Vonk, JM, Thomas, MJ et al.. Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts. Acta Biomater. 2024;177 :118-131. doi: 10.1016/j.actbio.2024.02.008. PubMed PMID:38350556 .
  • Khalenkow, D, Brandsma, CA, Timens, W, Choy, DF, Grimbaldeston, MA, Rosenberger, CM et al.. Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe COPD. Am J Respir Cell Mol Biol. 2024; :. doi: 10.1165/rcmb.2023-0296OC. PubMed PMID:38315810 .
  • Faiz, A, Wiersma, VR, Salzbrunn, JB, Brandsma, CA, Timens, W, Burgess, JK et al.. COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities. Arch Bronconeumol. 2024;60 (2):119-121. doi: 10.1016/j.arbres.2023.12.011. PubMed PMID:38212182 .
  • Burgess, JK, Weiss, DJ, Westergren-Thorsson, G, Wigen, J, Dean, CH, Mumby, S et al.. Extracellular Matrix as a Driver of Chronic Lung Diseases. Am J Respir Cell Mol Biol. 2024;70 (4):239-246. doi: 10.1165/rcmb.2023-0176PS. PubMed PMID:38190723 .
  • Voskamp, AL, de Jong, NW, Jochems, SP, Ozir-Fazalalikhan, A, van Hengel, ORJ, van der Vlugt, LEPM et al.. Early expansion of allergen-responsive LAP+ B regulatory cells in allergic rhinitis but not in allergic asthma subjects during allergen immunotherapy. Allergy. 2024;79 (4):1060-1064. doi: 10.1111/all.15973. PubMed PMID:38169044 .
  • Thiam, F, Faiz, A, Pouwels, SD, Osei, ET. Editorial: Next generation in vitro models to study chronic pulmonary diseases. Front Med (Lausanne). 2023;10 :1338939. doi: 10.3389/fmed.2023.1338939. PubMed PMID:38116037 PubMed Central PMC10728868.
  • El-Husseini, ZW, Khalenkow, D, Lan, A, van der Molen, T, Brightling, C, Papi, A et al.. An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma. Respir Res. 2023;24 (1):308. doi: 10.1186/s12931-023-02617-w. PubMed PMID:38062491 PubMed Central PMC10704725.
  • Saikumar Jayalatha, AK, Jonker, MR, Carpaij, OA, van den Berge, M, Affleck, KX, Koppelman, GH et al.. Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33. Am J Physiol Lung Cell Mol Physiol. 2024;326 (1):L65-L70. doi: 10.1152/ajplung.00298.2023. PubMed PMID:38050688 .
  • Berg, M, Petoukhov, I, van den Ende, I, Meyer, KB, Guryev, V, Vonk, JM et al.. FastCAR: fast correction for ambient RNA to facilitate differential gene expression analysis in single-cell RNA-sequencing datasets. BMC Genomics. 2023;24 (1):722. doi: 10.1186/s12864-023-09822-3. PubMed PMID:38030970 PubMed Central PMC10687889.
  • Song, S, van Dijk, F, Vasse, GF, Liu, Q, Gosselink, IF, Weltjens, E et al.. Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation. Am J Respir Crit Care Med. 2024;209 (4):427-443. doi: 10.1164/rccm.202211-2099OC. PubMed PMID:37971785 .
  • Migulina, N, de Hilster, RHJ, Bartel, S, Vedder, RHJ, van den Berge, M, Nagelkerke, A et al.. 3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes. Am J Physiol Cell Physiol. 2024;326 (1):C177-C193. doi: 10.1152/ajpcell.00374.2023. PubMed PMID:37955339 .
  • Zhang, M, Zhao, F, Zhang, X, Brouwer, LA, Burgess, JK, Harmsen, MC et al.. Fibroblasts alter the physical properties of dermal ECM-derived hydrogels to create a pro-angiogenic microenvironment. Mater Today Bio. 2023;23 :100842. doi: 10.1016/j.mtbio.2023.100842. PubMed PMID:37942422 PubMed Central PMC10628774.
  • Nizamoglu, M, Koloko Ngassie, ML, Meuleman, RA, Banchero, M, Borghuis, T, Timens, W et al.. Collagen type XIV is proportionally lower in the lung tissue of patients with IPF. Sci Rep. 2023;13 (1):19393. doi: 10.1038/s41598-023-46733-5. PubMed PMID:37938243 PubMed Central PMC10632429.
  • Wijsman, PC, Goorsenberg, AWM, Keijzer, N, d'Hooghe, JNS, Ten Hacken, NHT, Shah, PL et al.. Airway wall extracellular matrix changes induced by bronchial thermoplasty in severe asthma. J Allergy Clin Immunol. 2024;153 (2):435-446.e4. doi: 10.1016/j.jaci.2023.09.035. PubMed PMID:37805024 .
  • Hiemstra, PS, Heijink, IH. Oxidation alters IL-33 function: new insights in the biology of different forms of IL-33 and their relevance for COPD. Eur Respir J. 2023;62 (3):. doi: 10.1183/13993003.01301-2023. PubMed PMID:37770091 .
  • Faiz, A, Mahbub, RM, Boedijono, FS, Tomassen, MI, Kooistra, W, Timens, W et al.. IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels. Am J Respir Crit Care Med. 2023;208 (10):1075-1087. doi: 10.1164/rccm.202210-1881OC. PubMed PMID:37708400 PubMed Central PMC10867944.
  • Melén, E, Lambrecht, BN, Lloyd, CM, Rothenberg, ME, Kabashima, K, Luciani, F et al.. A conversation on allergy: recognizing the past and looking to the future. Immunol Cell Biol. 2023;101 (10):936-946. doi: 10.1111/imcb.12688. PubMed PMID:37688499 .
  • Wisman, M, Nizamoglu, M, Noordhoek, JA, Timens, W, Burgess, JK, Heijink, IH et al.. Dysregulated cross-talk between alveolar epithelial cells and stromal cells in idiopathic pulmonary fibrosis reduces epithelial regenerative capacity. Front Med (Lausanne). 2023;10 :1182368. doi: 10.3389/fmed.2023.1182368. PubMed PMID:37621459 PubMed Central PMC10446880.
  • Chen, Q, Vasse, GF, Nwozor, KO, Bekker, NJ, van den Berge, M, Brandsma, CA et al.. FAM13A regulates cellular senescence marker p21 and mitochondrial reactive oxygen species production in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2023;325 (4):L460-L466. doi: 10.1152/ajplung.00141.2023. PubMed PMID:37605846 .
  • van Breugel, M, Fehrmann, RSN, Bügel, M, Rezwan, FI, Holloway, JW, Nawijn, MC et al.. Current state and prospects of artificial intelligence in allergy. Allergy. 2023;78 (10):2623-2643. doi: 10.1111/all.15849. PubMed PMID:37584170 .
  • Gupta, A, Burgess, JK, Slebos, DJ, Pouwels, SD. The development, validation, and in vivo testing of a high-precision bronchial epithelial lining fluid sampling device. Front Med (Lausanne). 2023;10 :1172622. doi: 10.3389/fmed.2023.1172622. PubMed PMID:37564050 PubMed Central PMC10410264.
  • Baalbaki, N, Blankestijn, JM, Abdel-Aziz, MI, de Backer, J, Bazdar, S, Beekers, I et al.. Precision Medicine for More Oxygen (P4O2)-Study Design and First Results of the Long COVID-19 Extension. J Pers Med. 2023;13 (7):. doi: 10.3390/jpm13071060. PubMed PMID:37511673 PubMed Central PMC10381397.
  • Nizamoglu, M, Joglekar, MM, Almeida, CR, Larsson Callerfelt, AK, Dupin, I, Guenat, OT et al.. Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research. Eur Respir Rev. 2023;32 (169):. doi: 10.1183/16000617.0042-2023. PubMed PMID:37495250 PubMed Central PMC10369168.
  • Pouwels, SD, Sigaeva, A, de Boer, S, Eichhorn, IA, Koll, L, Kuipers, J et al.. Host-device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling. J Mater Sci Mater Med. 2023;34 (7):38. doi: 10.1007/s10856-023-06742-2. PubMed PMID:37486435 PubMed Central PMC10366254.
  • Van Buren, E, Radicioni, G, Lester, S, O'Neal, WK, Dang, H, Kasela, S et al.. Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes. PLoS Genet. 2023;19 (6):e1010445. doi: 10.1371/journal.pgen.1010445. PubMed PMID:37352370 PubMed Central PMC10325042.
  • Pinheiro-Machado, E, Getova, VE, Harmsen, MC, Burgess, JK, Smink, AM. Towards standardization of human adipose-derived stromal cells secretomes. Stem Cell Rev Rep. 2023;19 (7):2131-2140. doi: 10.1007/s12015-023-10567-5. PubMed PMID:37300663 PubMed Central PMC10579120.
  • Sikkema, L, Ramírez-Suástegui, C, Strobl, DC, Gillett, TE, Zappia, L, Madissoon, E et al.. An integrated cell atlas of the lung in health and disease. Nat Med. 2023;29 (6):1563-1577. doi: 10.1038/s41591-023-02327-2. PubMed PMID:37291214 PubMed Central PMC10287567.
  • Kapellos, TS, Nawijn, MC. Editorial: Molecular mechanisms regulating phenotypic heterogeneity in human inflammatory diseases. Front Immunol. 2023;14 :1214255. doi: 10.3389/fimmu.2023.1214255. PubMed PMID:37266418 PubMed Central PMC10231677.
  • Kapellos, TS, Baßler, K, Fujii, W, Nalkurthi, C, Schaar, AC, Bonaguro, L et al.. Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease. Cell Rep. 2023;42 (6):112525. doi: 10.1016/j.celrep.2023.112525. PubMed PMID:37243592 PubMed Central PMC10320832.
  • Roodenburg, SA, Pouwels, SD, Klooster, K, Touw, DJ, Slebos, DJ. Endobronchial Valve Treatment Does Not Cause Significant Nickel Deposition in Lung Tissue. Respiration. 2023;102 (6):454-457. doi: 10.1159/000529889. PubMed PMID:37231891 .
  • Kortekaas, RK, Geillinger-Kästle, KE, Borghuis, T, Belharch, K, Webster, M, Timens, W et al.. Interleukin-11 disrupts alveolar epithelial progenitor function. ERJ Open Res. 2023;9 (3):. doi: 10.1183/23120541.00679-2022. PubMed PMID:37228276 PubMed Central PMC10204861.
  • Pouwels, SD, van den Berge, M, Vasse, GF, Timens, W, Brandsma, CA, Aliee, H et al.. Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium. Respir Res. 2023;24 (1):130. doi: 10.1186/s12931-023-02430-5. PubMed PMID:37170105 PubMed Central PMC10174605.
  • Gay, ACA, Nawijn, MC. See no allergen, hear no allergen, speak no allergen!. Sci Immunol. 2023;8 (83):eadh0597. doi: 10.1126/sciimmunol.adh0597. PubMed PMID:37146130 .
  • Cuevas Ocaña, S, El-Merhie, N, Kuipers, ME, Lehmann, M, Enes, SR, Voss, C et al.. ERS International Congress 2022: highlights from the Basic and Translational Science Assembly. ERJ Open Res. 2023;9 (2):. doi: 10.1183/23120541.00561-2022. PubMed PMID:37077558 PubMed Central PMC10107060.
  • Koloko Ngassie, ML, De Vries, M, Borghuis, T, Timens, W, Sin, DD, Nickle, D et al.. Age-associated differences in the human lung extracellular matrix. Am J Physiol Lung Cell Mol Physiol. 2023;324 (6):L799-L814. doi: 10.1152/ajplung.00334.2022. PubMed PMID:37039368 PubMed Central PMC10202478.
  • Kole, TM, Pouwels, SD, Bults, R, Ketelaar, ME, Guryev, V, Koll, L et al.. Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms. ERJ Open Res. 2023;9 (2):. doi: 10.1183/23120541.00413-2022. PubMed PMID:37020836 PubMed Central PMC10068516.
  • Nizamoglu, M, Burgess, JK. Current possibilities and future opportunities provided by three-dimensional lung ECM-derived hydrogels. Front Pharmacol. 2023;14 :1154193. doi: 10.3389/fphar.2023.1154193. PubMed PMID:36969853 PubMed Central PMC10034771.
  • Muiser, S, Imkamp, K, Seigers, D, Halbersma, NJ, Vonk, JM, Luijk, BHD et al.. Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD. Thorax. 2023;78 (5):451-458. doi: 10.1136/thorax-2022-219620. PubMed PMID:36725331 .
  • Rathnayake, SNH, Ditz, B, Willemse, BWM, National Heart, Lung, and Blood Institute LungMAP Consortium, Timens, W, Kooistra, W et al.. Longitudinal Effects of 1-Year Smoking Cessation on Human Bronchial Epithelial Transcriptome. Chest. 2023;164 (1):85-89. doi: 10.1016/j.chest.2022.12.050. PubMed PMID:36716955 PubMed Central PMC10331623.
  • Kruk, D, Yeung, ACY, Faiz, A, Ten Hacken, NHT, Timens, W, van Kuppevelt, TH et al.. Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls. Respir Res. 2023;24 (1):22. doi: 10.1186/s12931-023-02314-8. PubMed PMID:36681830 PubMed Central PMC9863276.
  • Ciminieri, C, Woest, ME, Reynaert, NL, Heijink, IH, Wardenaar, R, Spierings, DCJ et al.. IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors' Function. Am J Respir Cell Mol Biol. 2023;68 (4):444-455. doi: 10.1165/rcmb.2022-0209OC. PubMed PMID:36608844 .
  • Faiz, A, Pavlidis, S, Kuo, CH, Rowe, A, Hiemstra, PS, Timens, W et al.. Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD. Thorax. 2023;78 (4):335-343. doi: 10.1136/thorax-2021-217736. PubMed PMID:36598042 PubMed Central PMC10086461.
  • van Breugel, M, Qi, C, Xu, Z, Pedersen, CT, Petoukhov, I, Vonk, JM et al.. Nasal DNA methylation at three CpG sites predicts childhood allergic disease. Nat Commun. 2022;13 (1):7415. doi: 10.1038/s41467-022-35088-6. PubMed PMID:36456559 PubMed Central PMC9715628.
  • Blokland, KEC, Nizamoglu, M, Habibie, H, Borghuis, T, Schuliga, M, Melgert, BN et al.. Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts. Front Pharmacol. 2022;13 :989169. doi: 10.3389/fphar.2022.989169. PubMed PMID:36408252 PubMed Central PMC9673045.
  • Joglekar, MM, Nizamoglu, M, Fan, Y, Nemani, SSP, Weckmann, M, Pouwels, SD et al.. Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases. Front Pharmacol. 2022;13 :995051. doi: 10.3389/fphar.2022.995051. PubMed PMID:36408219 PubMed Central PMC9669433.
  • Chen, Q, Nwozor, KO, van den Berge, M, Slebos, DJ, Faiz, A, Jonker, MR et al.. From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke. Cells. 2022;11 (21):. doi: 10.3390/cells11213423. PubMed PMID:36359818 PubMed Central PMC9656229.
  • Zhang, M, Getova, VE, Martinez-Garcia, FD, Borghuis, T, Burgess, JK, Harmsen, MC et al.. From Macro to Micro: Comparison of Imaging Techniques to Detect Vascular Network Formation in Left Ventricle Decellularized Extracellular Matrix Hydrogels. Gels. 2022;8 (11):. doi: 10.3390/gels8110729. PubMed PMID:36354636 PubMed Central PMC9689814.
  • Wiersma, VR, Hoonhorst, SJM, Ten Hacken, NHT, van den Berge, M, Slebos, DJ, Pouwels, SD et al.. The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils. Lung. 2022;200 (6):687-690. doi: 10.1007/s00408-022-00585-4. PubMed PMID:36282357 PubMed Central PMC9675764.
  • Martinez-Garcia, FD, Fischer, T, Hayn, A, Mierke, CT, Burgess, JK, Harmsen, MC et al.. A Beginner's Guide to the Characterization of Hydrogel Microarchitecture for Cellular Applications. Gels. 2022;8 (9):. doi: 10.3390/gels8090535. PubMed PMID:36135247 PubMed Central PMC9498492.
  • Onnes, MC, Alheraky, A, Nawijn, MC, Sluijter, TE, Mulder, AB, Arends, S et al.. Detection of clonal mast cell disease in wasp venom allergic patients with normal tryptase. Clin Transl Allergy. 2022;12 (9):e12174. doi: 10.1002/clt2.12174. PubMed PMID:36090584 PubMed Central PMC9449818.
  • van der Does, AM, Mahbub, RM, Ninaber, DK, Rathnayake, SNH, Timens, W, van den Berge, M et al.. Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa. Respir Res. 2022;23 (1):227. doi: 10.1186/s12931-022-02150-2. PubMed PMID:36056356 PubMed Central PMC9440516.
  • Hulina-Tomašković, A, Somborac-Bačura, A, Grdić Rajković, M, Hlapčić, I, Jonker, MR, Heijink, IH et al.. Extracellular Hsp70 modulates 16HBE cells' inflammatory responses to cigarette smoke and bacterial components lipopolysaccharide and lipoteichoic acid. Cell Stress Chaperones. 2022;27 (5):587-597. doi: 10.1007/s12192-022-01294-w. PubMed PMID:36029374 PubMed Central PMC9485373.
  • Kole, TM, Vanden Berghe, E, Kraft, M, Vonk, JM, Nawijn, MC, Siddiqui, S et al.. Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study. Lancet Respir Med. 2023;11 (1):55-64. doi: 10.1016/S2213-2600(22)00185-0. PubMed PMID:35907424 .
  • Martinez-Garcia, FD, van Dongen, JA, Burgess, JK, Harmsen, MC. Matrix Metalloproteases from Adipose Tissue-Derived Stromal Cells Are Spatiotemporally Regulated by Hydrogel Mechanics in a 3D Microenvironment. Bioengineering (Basel). 2022;9 (8):. doi: 10.3390/bioengineering9080340. PubMed PMID:35892753 PubMed Central PMC9332414.
  • Wildung, M, Herr, C, Riedel, D, Wiedwald, C, Moiseenko, A, Ramírez, F et al.. miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly. Int J Mol Sci. 2022;23 (14):. doi: 10.3390/ijms23147749. PubMed PMID:35887096 PubMed Central PMC9320302.
  • Al-Adwi, Y, Westra, J, van Goor, H, Burgess, JK, Denton, CP, Mulder, DJ et al.. Macrophages as determinants and regulators of fibrosis in systemic sclerosis. Rheumatology (Oxford). 2023;62 (2):535-545. doi: 10.1093/rheumatology/keac410. PubMed PMID:35861385 PubMed Central PMC9891414.
  • Ikonomou, L, Magnusson, M, Dries, R, Herzog, EL, Hynds, RE, Borok, Z et al.. Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. Am J Physiol Lung Cell Mol Physiol. 2022;323 (3):L341-L354. doi: 10.1152/ajplung.00113.2022. PubMed PMID:35762622 PubMed Central PMC9484991.
  • Qi, C, Berg, M, Chu, X, Timens, W, Kole, T, van den Berge, M et al.. Cell-type eQTL deconvolution of bronchial epithelium through integration of single-cell and bulk RNA-seq. Allergy. 2022;77 (12):3663-3666. doi: 10.1111/all.15410. PubMed PMID:35708915 .
  • Migulina, N, Tjin, G, Faiz, A, Borghuis, T, Zhao, F, Kaper, HJ et al.. Differential roles for lysyl oxidase (like), family members in chronic obstructive pulmonary disease; from gene and protein expression to function. FASEB J. 2022;36 (7):e22374. doi: 10.1096/fj.202101553R. PubMed PMID:35670745 .
  • Ting, AE, Baker, EK, Champagne, J, Desai, TJ, Dos Santos, CC, Heijink, IH et al.. Proceedings of the ISCT scientific signature series symposium, "Advances in cell and gene therapies for lung diseases and critical illnesses": International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021. Cytotherapy. 2022;24 (8):774-788. doi: 10.1016/j.jcyt.2021.11.007. PubMed PMID:35613962 .
  • Nizamoglu, M, de Hilster, RHJ, Zhao, F, Sharma, PK, Borghuis, T, Harmsen, MC et al.. An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition. Acta Biomater. 2022;147 :50-62. doi: 10.1016/j.actbio.2022.05.031. PubMed PMID:35605955 .
  • Aghapour, M, Ubags, ND, Bruder, D, Hiemstra, PS, Sidhaye, V, Rezaee, F et al.. Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. Eur Respir Rev. 2022;31 (163):. doi: 10.1183/16000617.0112-2021. PubMed PMID:35321933 PubMed Central PMC9128841.
  • Burgess, JK, Harmsen, MC. Chronic lung diseases: entangled in extracellular matrix. Eur Respir Rev. 2022;31 (163):. doi: 10.1183/16000617.0202-2021. PubMed PMID:35264410 PubMed Central PMC9488575.
  • de Vries, M, Nwozor, KO, Muizer, K, Wisman, M, Timens, W, van den Berge, M et al.. The relation between age and airway epithelial barrier function. Respir Res. 2022;23 (1):43. doi: 10.1186/s12931-022-01961-7. PubMed PMID:35241091 PubMed Central PMC8892715.
  • Tasena, H, Timens, W, van den Berge, M, van Broekhuizen, J, Kennedy, BK, Hylkema, MN et al.. MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast-Epithelium Crosstalk. Cells. 2022;11 (3):. doi: 10.3390/cells11030526. PubMed PMID:35159335 PubMed Central PMC8833971.
  • Luecken, MD, Zaragosi, LE, Madissoon, E, Sikkema, L, Firsova, AB, De Domenico, E et al.. The discovAIR project: a roadmap towards the Human Lung Cell Atlas. Eur Respir J. 2022;60 (2):. doi: 10.1183/13993003.02057-2021. PubMed PMID:35086829 PubMed Central PMC9386332.
  • Klont, F, Horvatovich, P, Bowler, RP, van Rikxoort, E, Charbonnier, JP, Kwiatkowski, M et al.. Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans. Respir Res. 2022;23 (1):15. doi: 10.1186/s12931-022-01934-w. PubMed PMID:35073932 PubMed Central PMC8785488.
  • Hesse, L, Oude Elberink, JNG, van Oosterhout, AJM, Nawijn, MC. Allergen immunotherapy for allergic airway diseases: Use lessons from the past to design a brighter future. Pharmacol Ther. 2022;237 :108115. doi: 10.1016/j.pharmthera.2022.108115. PubMed PMID:35063570 .
  • Benam, KH, Burgess, JK, Stewart, AG. Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models. Front Pharmacol. 2021;12 :827172. doi: 10.3389/fphar.2021.827172. PubMed PMID:35046832 PubMed Central PMC8762276.
  • Gupta, A, Burgess, JK, Borghuis, T, de Vries, MP, Kuipers, J, Permentier, HP et al.. Identification of damage associated molecular patterns and extracellular matrix proteins as major constituents of the surface proteome of lung implantable silicone/nitinol devices. Acta Biomater. 2022;141 :209-218. doi: 10.1016/j.actbio.2022.01.016. PubMed PMID:35038586 .
  • Wiersma, VR, Pouwels, SD. An Integrative Genomic Strategy Identifies Soluble Receptor for Advanced Glycation End-Products as a Causal and Protective Biomarker of Lung Function. Chest. 2022;161 (1):3-5. doi: 10.1016/j.chest.2021.08.005. PubMed PMID:35000706 .
  • Dekkers, BGJ, Saad, SI, van Spelde, LJ, Burgess, JK. Basement membranes in obstructive pulmonary diseases. Matrix Biol Plus. 2021;12 :100092. doi: 10.1016/j.mbplus.2021.100092. PubMed PMID:34877523 PubMed Central PMC8632995.
  • Joglekar, MM, Slebos, DJ, Leijten, J, Burgess, JK, Pouwels, SD. Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction. Eur Respir Rev. 2021;30 (162):. doi: 10.1183/16000617.0142-2021. PubMed PMID:34853096 PubMed Central PMC9488910.
  • Moreno, P, Fexova, S, George, N, Manning, JR, Miao, Z, Mohammed, S et al.. Expression Atlas update: gene and protein expression in multiple species. Nucleic Acids Res. 2022;50 (D1):D129-D140. doi: 10.1093/nar/gkab1030. PubMed PMID:34850121 PubMed Central PMC8728300.
  • Kruk, DMLW, Wisman, M, Noordhoek, JA, Nizamoglu, M, Jonker, MR, de Bruin, HG et al.. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells. Cells. 2021;10 (11):. doi: 10.3390/cells10112860. PubMed PMID:34831082 PubMed Central PMC8616441.
  • Pouwels, SD, Burgess, JK, Verschuuren, E, Slebos, DJ. The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus. Respir Res. 2021;22 (1):285. doi: 10.1186/s12931-021-01882-x. PubMed PMID:34736473 PubMed Central PMC8570005.
  • Aliee, H, Massip, F, Qi, C, Stella de Biase, M, van Nijnatten, J, Kersten, ETG et al.. Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways. Allergy. 2022;77 (2):690-694. doi: 10.1111/all.15152. PubMed PMID:34698405 PubMed Central PMC8652715.
  • Klont, F, Kwiatkowski, M, Faiz, A, van den Bosch, T, Pouwels, SD, Dekker, FJ et al.. Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows. J Proteome Res. 2021;20 (11):5218-5221. doi: 10.1021/acs.jproteome.1c00623. PubMed PMID:34669399 PubMed Central PMC8576839.
  • Roffel, MP, Maes, T, Brandsma, CA, van den Berge, M, Vanaudenaerde, BM, Joos, GF et al.. MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation. Am J Physiol Lung Cell Mol Physiol. 2021;321 (6):L1091-L1104. doi: 10.1152/ajplung.00252.2021. PubMed PMID:34668437 .
  • Dinesh Kumar, N, Ter Ellen, BM, Bouma, EM, Troost, B, van de Pol, DPI, van der Ende-Metselaar, HH et al.. Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells. Antimicrob Agents Chemother. 2022;66 (1):e0154321. doi: 10.1128/AAC.01543-21. PubMed PMID:34633839 PubMed Central PMC8765325.
  • Martinez-Garcia, FD, de Hilster, RHJ, Sharma, PK, Borghuis, T, Hylkema, MN, Burgess, JK et al.. Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels. Polymers (Basel). 2021;13 (18):. doi: 10.3390/polym13183113. PubMed PMID:34578013 PubMed Central PMC8470996.
  • Martinez-Garcia, FD, Valk, MM, Sharma, PK, Burgess, JK, Harmsen, MC. Adipose Tissue-Derived Stromal Cells Alter the Mechanical Stability and Viscoelastic Properties of Gelatine Methacryloyl Hydrogels. Int J Mol Sci. 2021;22 (18):. doi: 10.3390/ijms221810153. PubMed PMID:34576318 PubMed Central PMC8468163.
  • Waters, DW, Schuliga, M, Pathinayake, PS, Wei, L, Tan, HY, Blokland, KEC et al.. A Senescence Bystander Effect in Human Lung Fibroblasts. Biomedicines. 2021;9 (9):. doi: 10.3390/biomedicines9091162. PubMed PMID:34572347 PubMed Central PMC8470192.
  • Schuliga, M, Kanwal, A, Read, J, Blokland, KEC, Burgess, JK, Prêle, CM et al.. A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF. Am J Physiol Lung Cell Mol Physiol. 2021;321 (5):L859-L871. doi: 10.1152/ajplung.00574.2020. PubMed PMID:34524912 .
  • Roffel, MP, Boudewijn, IM, van Nijnatten, JLL, Faiz, A, Vermeulen, CJ, van Oosterhout, AJ et al.. Identification of asthma-associated microRNAs in bronchial biopsies. Eur Respir J. 2022;59 (3):. doi: 10.1183/13993003.01294-2021. PubMed PMID:34446467 .
  • Chen, Q, Heijink, IH, de Vries, M. Connecting GWAS Susceptibility Genes in COPD: Do We Need to Consider TGF-β2?. Am J Respir Cell Mol Biol. 2021;65 (5):468-470. doi: 10.1165/rcmb.2021-0265ED. PubMed PMID:34411507 PubMed Central PMC8641857.
  • Pouwels, SD, Hesse, L, Wu, X, Allam, VSRR, van Oldeniel, D, Bhiekharie, LJ et al.. LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE. Am J Physiol Lung Cell Mol Physiol. 2021;321 (4):L641-L652. doi: 10.1152/ajplung.00138.2021. PubMed PMID:34405719 .
  • Vasse, GF, Van Os, L, De Jager, M, Jonker, MR, Borghuis, T, Van Den Toorn, LT et al.. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices. Front Pharmacol. 2021;12 :669037. doi: 10.3389/fphar.2021.669037. PubMed PMID:34393771 PubMed Central PMC8355988.
  • Kuchibhotla, VNS, Starkey, MR, Reid, AT, Heijink, IH, Nawijn, MC, Hansbro, PM et al.. Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice. Front Physiol. 2021;12 :690531. doi: 10.3389/fphys.2021.690531. PubMed PMID:34385933 PubMed Central PMC8353457.
  • Ter Ellen, BM, Dinesh Kumar, N, Bouma, EM, Troost, B, van de Pol, DPI, van der Ende-Metselaar, HH et al.. Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells. Viruses. 2021;13 (7):. doi: 10.3390/v13071335. PubMed PMID:34372541 PubMed Central PMC8309965.
  • Roodenburg, SA, Pouwels, SD, Slebos, DJ. Airway granulation response to lung-implantable medical devices: a concise overview. Eur Respir Rev. 2021;30 (161):. doi: 10.1183/16000617.0066-2021. PubMed PMID:34348981 PubMed Central PMC9488845.
  • Weckmann, M, Bahmer, T, Sand, JM, Rank Rønnow, S, Pech, M, Vermeulen, C et al.. COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J. 2021;58 (6):. doi: 10.1183/13993003.03969-2020. PubMed PMID:34326188 .
  • Blokland, KEC, Habibie, H, Borghuis, T, Teitsma, GJ, Schuliga, M, Melgert, BN et al.. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM. Cells. 2021;10 (7):. doi: 10.3390/cells10071628. PubMed PMID:34209854 PubMed Central PMC8307656.
  • Faiz, A, Rathnayake, SNH, Ten Hacken, NHT, Guryev, V, van den Berge, M, Pouwels, SD et al.. Single-nucleotide polymorphism rs2070600 regulates AGER splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products. ERJ Open Res. 2021;7 (2):. doi: 10.1183/23120541.00947-2020. PubMed PMID:34195255 PubMed Central PMC8236754.
  • Chen, Q, de Vries, M, Nwozor, KO, Noordhoek, JA, Brandsma, CA, Boezen, HM et al.. A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract. Front Physiol. 2021;12 :690936. doi: 10.3389/fphys.2021.690936. PubMed PMID:34163376 PubMed Central PMC8215130.
  • Schiller, HB, van Breugel, M, Nawijn, MC. SARS-CoV-2-specific hotspots in virus-host interaction networks. Nat Immunol. 2021;22 (7):806-808. doi: 10.1038/s41590-021-00963-9. PubMed PMID:34155406 .
  • Faiz, A, Harkness, LM, Tjin, G, Bernal, V, Horvatovich, P, James, A et al.. Angiogenic regulatory influence of extracellular matrix deposited by resting state asthmatic and non-asthmatic airway smooth muscle cells is similar. J Cell Mol Med. 2021;25 (13):6438-6447. doi: 10.1111/jcmm.16648. PubMed PMID:34146379 PubMed Central PMC8256353.
  • Nemani, SSP, Vermeulen, CJ, Pech, M, Faiz, A, Oliver, BGG, van den Berge, M et al.. COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding. ERJ Open Res. 2021;7 (2):. doi: 10.1183/23120541.00802-2020. PubMed PMID:34109240 PubMed Central PMC8181658.
  • Schupp, JC, Adams, TS, Cosme, C Jr, Raredon, MSB, Yuan, Y, Omote, N et al.. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation. 2021;144 (4):286-302. doi: 10.1161/CIRCULATIONAHA.120.052318. PubMed PMID:34030460 PubMed Central PMC8300155.
  • van der Ploeg, EA, Melgert, BN, Burgess, JK, Gan, CT. The potential of biomarkers of fibrosis in chronic lung allograft dysfunction. Transplant Rev (Orlando). 2021;35 (3):100626. doi: 10.1016/j.trre.2021.100626. PubMed PMID:33992914 .
  • van de Wetering, C, Elko, E, Berg, M, Schiffers, CHJ, Stylianidis, V, van den Berge, M et al.. Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?. Redox Biol. 2021;43 :101995. doi: 10.1016/j.redox.2021.101995. PubMed PMID:33979767 PubMed Central PMC8131726.
  • Pratte, KA, Curtis, JL, Kechris, K, Couper, D, Cho, MH, Silverman, EK et al.. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res. 2021;22 (1):127. doi: 10.1186/s12931-021-01686-z. PubMed PMID:33906653 PubMed Central PMC8076883.
  • Koloko Ngassie, ML, Brandsma, CA, Gosens, R, Prakash, YS, Burgess, JK. The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête. Physiology (Bethesda). 2021;36 (3):150-159. doi: 10.1152/physiol.00039.2020. PubMed PMID:33904785 .
  • Saikumar Jayalatha, AK, Hesse, L, Ketelaar, ME, Koppelman, GH, Nawijn, MC. The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention. Pharmacol Ther. 2021;225 :107847. doi: 10.1016/j.pharmthera.2021.107847. PubMed PMID:33819560 .
  • Hu, S, Martinez-Garcia, FD, Moeun, BN, Burgess, JK, Harmsen, MC, Hoesli, C et al.. An immune regulatory 3D-printed alginate-pectin construct for immunoisolation of insulin producing β-cells. Mater Sci Eng C Mater Biol Appl. 2021;123 :112009. doi: 10.1016/j.msec.2021.112009. PubMed PMID:33812628 .
  • Liu, G, Philp, AM, Corte, T, Travis, MA, Schilter, H, Hansbro, NG et al.. Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacol Ther. 2021;225 :107839. doi: 10.1016/j.pharmthera.2021.107839. PubMed PMID:33774068 .
  • Kruk, DMLW, Wisman, M, Bruin, HG, Lodewijk, ME, Hof, DJ, Borghuis, T et al.. Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema. Am J Physiol Lung Cell Mol Physiol. 2021;320 (5):L832-L844. doi: 10.1152/ajplung.00147.2020. PubMed PMID:33656381 .
  • Dwyer, DF, Ordovas-Montanes, J, Allon, SJ, Buchheit, KM, Vukovic, M, Derakhshan, T et al.. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021;6 (56):. doi: 10.1126/sciimmunol.abb7221. PubMed PMID:33637594 PubMed Central PMC8362933.
  • Kortekaas, RK, Burgess, JK, van Orsoy, R, Lamb, D, Webster, M, Gosens, R et al.. Therapeutic Targeting of IL-11 for Chronic Lung Disease. Trends Pharmacol Sci. 2021;42 (5):354-366. doi: 10.1016/j.tips.2021.01.007. PubMed PMID:33612289 .
  • Vasse, GF, Nizamoglu, M, Heijink, IH, Schlepütz, M, van Rijn, P, Thomas, MJ et al.. Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives. J Pathol. 2021;254 (4):344-357. doi: 10.1002/path.5632. PubMed PMID:33506963 PubMed Central PMC8252758.
  • Heijink, IH, Hackett, TL, Pouwels, SD. Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium†. J Pathol. 2021;253 (4):351-354. doi: 10.1002/path.5607. PubMed PMID:33368245 PubMed Central PMC7986690.
  • Xu, CJ, Gruzieva, O, Qi, C, Esplugues, A, Gehring, U, Bergström, A et al.. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol. 2021;147 (3):1031-1040. doi: 10.1016/j.jaci.2020.11.044. PubMed PMID:33338541 PubMed Central PMC8238013.
  • Ketelaar, ME, Westerlaken-van Ginkel, CD, Nawijn, MC, Ej Dubois, A, Koppelman, GH. IL-1RL1a serum levels and IL1RL1 SNPs in the prediction of food allergy. Clin Exp Allergy. 2021;51 (4):614-619. doi: 10.1111/cea.13802. PubMed PMID:33278838 PubMed Central PMC8048844.
  • Woldhuis, RR, Heijink, IH, van den Berge, M, Timens, W, Oliver, BGG, de Vries, M et al.. COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins. Thorax. 2021;76 (5):508-511. doi: 10.1136/thoraxjnl-2020-215114. PubMed PMID:33273021 PubMed Central PMC8070616.
  • Hesse, L, van Ieperen, N, Petersen, AH, Elberink, JNGO, van Oosterhout, AJM, Nawijn, MC et al.. High dose vitamin D3 empowers effects of subcutaneous immunotherapy in a grass pollen-driven mouse model of asthma. Sci Rep. 2020;10 (1):20876. doi: 10.1038/s41598-020-77947-6. PubMed PMID:33257771 PubMed Central PMC7705678.
  • Hesse, L, Petersen, AH, Nawijn, MC. Methods for Experimental Allergen Immunotherapy: Subcutaneous and Sublingual Desensitization in Mouse Models of Allergic Asthma. Methods Mol Biol. 2021;2223 :295-335. doi: 10.1007/978-1-0716-1001-5_20. PubMed PMID:33226602 .
  • Blokland, KEC, Pouwels, SD, Schuliga, M, Knight, DA, Burgess, JK. Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases. Clin Sci (Lond). 2020;134 (20):2681-2706. doi: 10.1042/CS20190893. PubMed PMID:33084883 PubMed Central PMC7578566.
  • Pouwels, SD, Wiersma, VR, Fokkema, IE, Berg, M, Ten Hacken, NHT, van den Berge, M et al.. Acute cigarette smoke-induced eQTL affects formyl peptide receptor expression and lung function. Respirology. 2021;26 (3):233-240. doi: 10.1111/resp.13960. PubMed PMID:33078507 PubMed Central PMC7983955.
  • Faiz, A, Imkamp, K, van der Wiel, E, Boudewijn, IM, Koppelman, GH, Brandsma, CA et al.. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Sci Rep. 2020;10 (1):17415. doi: 10.1038/s41598-020-72551-0. PubMed PMID:33060632 PubMed Central PMC7562702.
  • Marsh, EK, Prestwich, EC, Williams, L, Hart, AR, Muir, CF, Parker, LC et al.. Pellino-1 Regulates the Responses of the Airway to Viral Infection. Front Cell Infect Microbiol. 2020;10 :456. doi: 10.3389/fcimb.2020.00456. PubMed PMID:32984077 PubMed Central PMC7488214.
  • Jiang, J, Faiz, A, Berg, M, Carpaij, OA, Vermeulen, CJ, Brouwer, S et al.. Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma. Clin Exp Allergy. 2020;50 (12):1428-1431. doi: 10.1111/cea.13732. PubMed PMID:32935368 PubMed Central PMC7756890.
  • Aliee, H, Massip, F, Qi, C, de Biase, MS, van Nijnatten, J, Kersten, ETG et al.. Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways. medRxiv. 2020; :. doi: 10.1101/2020.08.31.20169946. PubMed PMID:32909007 PubMed Central PMC7480059.
  • Burgess, JK, Jonker, MR, Berg, M, Ten Hacken, NTH, Meyer, KB, van den Berge, M et al.. Periostin: contributor to abnormal airway epithelial function in asthma?. Eur Respir J. 2021;57 (2):. doi: 10.1183/13993003.01286-2020. PubMed PMID:32907887 .
  • Allam, VSRR, Faiz, A, Lam, M, Rathnayake, SNH, Ditz, B, Pouwels, SD et al.. RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD. Allergy. 2021;76 (4):1123-1135. doi: 10.1111/all.14563. PubMed PMID:32799375 .
  • Nawijn, MC, Timens, W. Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?. Mol Syst Biol. 2020;16 (7):e9841. doi: 10.15252/msb.20209841. PubMed PMID:32715628 PubMed Central PMC7383087.
  • Sungnak, W, Huang, N, Bécavin, C, Berg, M, HCA Lung Biological Network. SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways. ArXiv. 2020; :. . PubMed PMID:32550242 PubMed Central PMC7280877.
  • Roffel, MP, Bracke, KR, Heijink, IH, Maes, T. miR-223: A Key Regulator in the Innate Immune Response in Asthma and COPD. Front Med (Lausanne). 2020;7 :196. doi: 10.3389/fmed.2020.00196. PubMed PMID:32509795 PubMed Central PMC7249736.
  • Hesse, L, Petersen, AH, Oude Elberink, JNG, van Oosterhout, AJM, Nawijn, MC. 1,25(OH)2VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model. Sci Rep. 2020;10 (1):8960. doi: 10.1038/s41598-020-65946-6. PubMed PMID:32488022 PubMed Central PMC7265339.
  • Woldhuis, RR, de Vries, M, Timens, W, van den Berge, M, Demaria, M, Oliver, BGG et al.. Link between increased cellular senescence and extracellular matrix changes in COPD. Am J Physiol Lung Cell Mol Physiol. 2020;319 (1):L48-L60. doi: 10.1152/ajplung.00028.2020. PubMed PMID:32460521 .
  • Heijink, IH, Kuchibhotla, VNS, Roffel, MP, Maes, T, Knight, DA, Sayers, I et al.. Epithelial cell dysfunction, a major driver of asthma development. Allergy. 2020;75 (8):1902-1917. doi: 10.1111/all.14421. PubMed PMID:32460363 PubMed Central PMC7496351.
  • Osei, ET, B Mostaço-Guidolin, L, Hsieh, A, Warner, SM, Al-Fouadi, M, Wang, M et al.. Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma. Sci Rep. 2020;10 (1):8721. doi: 10.1038/s41598-020-65567-z. PubMed PMID:32457454 PubMed Central PMC7250866.
  • Ketelaar, ME, Portelli, MA, Dijk, FN, Shrine, N, Faiz, A, Vermeulen, CJ et al.. Phenotypic and functional translation of IL33 genetics in asthma. J Allergy Clin Immunol. 2021;147 (1):144-157. doi: 10.1016/j.jaci.2020.04.051. PubMed PMID:32442646 .
  • Carpaij, OA, Goorsenberg, AWM, d'Hooghe, JNS, de Bruin, DM, van den Elzen, RM, Nawijn, MC et al.. Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall. Am J Respir Crit Care Med. 2020;202 (5):762-766. doi: 10.1164/rccm.201908-1512LE. PubMed PMID:32352872 .
  • Blokland, KEC, Waters, DW, Schuliga, M, Read, J, Pouwels, SD, Grainge, CL et al.. Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing. Pharmaceutics. 2020;12 (4):. doi: 10.3390/pharmaceutics12040389. PubMed PMID:32344567 PubMed Central PMC7238173.
  • Boudewijn, IM, Roffel, MP, Vermeulen, CJ, Nawijn, MC, Kok, K, Terpstra, MM et al.. A Novel Role for Bronchial MicroRNAs and Long Noncoding RNAs in Asthma Remission. Am J Respir Crit Care Med. 2020;202 (4):614-618. doi: 10.1164/rccm.201908-1610LE. PubMed PMID:32339464 .
  • Sungnak, W, Huang, N, Bécavin, C, Berg, M, Queen, R, Litvinukova, M et al.. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26 (5):681-687. doi: 10.1038/s41591-020-0868-6. PubMed PMID:32327758 PubMed Central PMC8637938.
  • Portelli, MA, Dijk, FN, Ketelaar, ME, Shrine, N, Hankinson, J, Bhaker, S et al.. Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI Insight. 2020;5 (8):. doi: 10.1172/jci.insight.132446. PubMed PMID:32324168 PubMed Central PMC7205441.
  • Koopmans, T, Hesse, L, Nawijn, MC, Kumawat, K, Menzen, MH, Sophie T Bos, I et al.. Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation. Sci Rep. 2020;10 (1):6754. doi: 10.1038/s41598-020-63741-x. PubMed PMID:32317758 PubMed Central PMC7174298.
  • Ge, L, Yang, L, Bron, R, Burgess, JK, van Rijn, P. Topography-Mediated Fibroblast Cell Migration Is Influenced by Direction, Wavelength, and Amplitude. ACS Appl Bio Mater. 2020;3 (4):2104-2116. doi: 10.1021/acsabm.0c00001. PubMed PMID:35025262 .
  • Kuchibhotla, VNS, Heijink, IH. Join or Leave the Club: Jagged1 and Notch2 Dictate the Fate of Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2020;63 (1):4-6. doi: 10.1165/rcmb.2020-0104ED. PubMed PMID:32228394 PubMed Central PMC7328256.
  • Ubags, ND, Baker, J, Boots, A, Costa, R, El-Merhie, N, Fabre, A et al.. ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. ERJ Open Res. 2020;6 (1):. doi: 10.1183/23120541.00350-2019. PubMed PMID:32154289 PubMed Central PMC7049707.
  • van der Wijst, M, de Vries, DH, Groot, HE, Trynka, G, Hon, CC, Bonder, MJ et al.. The single-cell eQTLGen consortium. Elife. 2020;9 :. doi: 10.7554/eLife.52155. PubMed PMID:32149610 PubMed Central PMC7077978.
  • Ali, MK, Kim, RY, Brown, AC, Donovan, C, Vanka, KS, Mayall, JR et al.. Critical role for iron accumulation in the pathogenesis of fibrotic lung disease. J Pathol. 2020;251 (1):49-62. doi: 10.1002/path.5401. PubMed PMID:32083318 .
  • de Hilster, RHJ, Sharma, PK, Jonker, MR, White, ES, Gercama, EA, Roobeek, M et al.. Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue. Am J Physiol Lung Cell Mol Physiol. 2020;318 (4):L698-L704. doi: 10.1152/ajplung.00451.2019. PubMed PMID:32048864 PubMed Central PMC7191637.
  • Zuo, H, Trombetta-Lima, M, Heijink, IH, van der Veen, CHTJ, Hesse, L, Faber, KN et al.. A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition. Cells. 2020;9 (2):. doi: 10.3390/cells9020356. PubMed PMID:32028718 PubMed Central PMC7072527.
  • Kuchibhotla, VNS, Jonker, MR, de Bruin, HG, Noordhoek, JA, Knight, DA, Nawijn, MC et al.. Inhibition of β-catenin/CBP signalling improves airway epithelial barrier function and suppresses CCL20 release. Allergy. 2020;75 (7):1786-1789. doi: 10.1111/all.14216. PubMed PMID:32027380 PubMed Central PMC7383853.
  • Qi, C, Jiang, Y, Yang, IV, Forno, E, Wang, T, Vonk, JM et al.. Nasal DNA methylation profiling of asthma and rhinitis. J Allergy Clin Immunol. 2020;145 (6):1655-1663. doi: 10.1016/j.jaci.2019.12.911. PubMed PMID:31953105 PubMed Central PMC7282965.
  • Dijk, FN, Vijverberg, SJ, Hernandez-Pacheco, N, Repnik, K, Karimi, L, Mitratza, M et al.. IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy. 2020;75 (4):984-989. doi: 10.1111/all.14125. PubMed PMID:31755552 PubMed Central PMC7176513.
  • Osei, ET, Brandsma, CA, Timens, W, Heijink, IH, Hackett, TL. Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD. Eur Respir J. 2020;55 (2):. doi: 10.1183/13993003.00563-2019. PubMed PMID:31727692 .
  • Vermeulen, CJ, Xu, CJ, Vonk, JM, Ten Hacken, NHT, Timens, W, Heijink, IH et al.. Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission. Eur Respir J. 2020;55 (2):. doi: 10.1183/13993003.01280-2019. PubMed PMID:31699840 .
  • Aghapour, M, Remels, AHV, Pouwels, SD, Bruder, D, Hiemstra, PS, Cloonan, SM et al.. Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2020;318 (1):L149-L164. doi: 10.1152/ajplung.00329.2019. PubMed PMID:31693390 PubMed Central PMC6985875.
  • Imkamp, K, Bernal, V, Grzegorzcyk, M, Horvatovich, P, Vermeulen, CJ, Heijink, IH et al.. Gene network approach reveals co-expression patterns in nasal and bronchial epithelium. Sci Rep. 2019;9 (1):15835. doi: 10.1038/s41598-019-50963-x. PubMed PMID:31676779 PubMed Central PMC6825243.
  • Zuo, H, Faiz, A, van den Berge, M, Mudiyanselage, SNHR, Borghuis, T, Timens, W et al.. Cigarette smoke exposure alters phosphodiesterases in human structural lung cells. Am J Physiol Lung Cell Mol Physiol. 2020;318 (1):L59-L64. doi: 10.1152/ajplung.00319.2019. PubMed PMID:31664853 .
  • Carpaij, OA, Muiser, S, Bell, AJ, Kerstjens, HAM, Galban, CJ, Fortuna, AB et al.. Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air. ERJ Open Res. 2019;5 (4):. doi: 10.1183/23120541.00202-2019. PubMed PMID:31649950 PubMed Central PMC6801216.
  • Hoffmann, RF, Jonker, MR, Brandenburg, SM, de Bruin, HG, Ten Hacken, NHT, van Oosterhout, AJM et al.. Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium. Sci Rep. 2019;9 (1):15047. doi: 10.1038/s41598-019-51517-x. PubMed PMID:31636329 PubMed Central PMC6803636.
  • Schenk, HM, van Ockenburg, SL, Nawijn, MC, De Jonge, P, Rosmalen, JGM. Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study. PLoS One. 2019;14 (9):e0221993. doi: 10.1371/journal.pone.0221993. PubMed PMID:31550260 PubMed Central PMC6759186.
  • Tasena, H, Boudewijn, IM, Faiz, A, Timens, W, Hylkema, MN, Berg, M et al.. MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease. Allergy. 2020;75 (3):703-706. doi: 10.1111/all.14060. PubMed PMID:31545509 .
  • Wiersma, VR, Clarke, A, Pouwels, SD, Perry, E, Abdullah, TM, Kelly, C et al.. Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes. Int J Mol Sci. 2019;20 (16):. doi: 10.3390/ijms20164046. PubMed PMID:31430907 PubMed Central PMC6721145.
  • Liu, G, Cooley, MA, Jarnicki, AG, Borghuis, T, Nair, PM, Tjin, G et al.. Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis. JCI Insight. 2019;5 (16):. doi: 10.1172/jci.insight.124529. PubMed PMID:31343988 PubMed Central PMC6777837.
  • Blais-Lecours, P, Laouafa, S, Arias-Reyes, C, Santos, WL, Joseph, V, Burgess, JK et al.. Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis. Am J Respir Cell Mol Biol. 2020;62 (1):35-42. doi: 10.1165/rcmb.2018-0397OC. PubMed PMID:31247144 PubMed Central PMC6938129.
  • Boudewijn, IM, Lan, A, Faiz, A, Cox, CA, Brouwer, S, Schokker, S et al.. Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy. 2020;75 (1):191-194. doi: 10.1111/all.13952. PubMed PMID:31230369 .
  • Vieira Braga, FA, Kar, G, Berg, M, Carpaij, OA, Polanski, K, Simon, LM et al.. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat Med. 2019;25 (7):1153-1163. doi: 10.1038/s41591-019-0468-5. PubMed PMID:31209336 .
  • Klont, F, Pouwels, SD, Bults, P, van de Merbel, NC, Ten Hacken, NHT, Horvatovich, P et al.. Quantification of surfactant protein D (SPD) in human serum by liquid chromatography-mass spectrometry (LC-MS). Talanta. 2019;202 :507-513. doi: 10.1016/j.talanta.2019.05.028. PubMed PMID:31171213 .
  • Hesse, L, Feenstra, R, Ambrosini, M, de Jager, WA, Petersen, A, Vietor, H et al.. Subcutaneous immunotherapy using modified Phl p5a-derived peptides efficiently alleviates allergic asthma in mice. Allergy. 2019;74 (12):2495-2498. doi: 10.1111/all.13918. PubMed PMID:31124150 PubMed Central PMC6972669.
  • Nikolić, MZ, Garrido-Martin, EM, Greiffo, FR, Fabre, A, Heijink, IH, Boots, A et al.. From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science.". ERJ Open Res. 2019;5 (2):. doi: 10.1183/23120541.00194-2018. PubMed PMID:31111040 PubMed Central PMC6513036.
  • Carpaij, OA, Burgess, JK, Kerstjens, HAM, Nawijn, MC, van den Berge, M. A review on the pathophysiology of asthma remission. Pharmacol Ther. 2019;201 :8-24. doi: 10.1016/j.pharmthera.2019.05.002. PubMed PMID:31075356 .
  • Murtha, LA, Morten, M, Schuliga, MJ, Mabotuwana, NS, Hardy, SA, Waters, DW et al.. The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis. Aging Dis. 2019;10 (2):419-428. doi: 10.14336/AD.2018.0601. PubMed PMID:31011486 PubMed Central PMC6457057.
  • Burgess, JK, Weckmann, M, Karsdal, MA. The message from the matrix-should we listen more closely?. J Thorac Dis. 2019;11 (Suppl 3):S230-S233. doi: 10.21037/jtd.2019.01.68. PubMed PMID:30997184 PubMed Central PMC6424747.
  • Schiller, HB, Montoro, DT, Simon, LM, Rawlins, EL, Meyer, KB, Strunz, M et al.. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. Am J Respir Cell Mol Biol. 2019;61 (1):31-41. doi: 10.1165/rcmb.2018-0416TR. PubMed PMID:30995076 PubMed Central PMC6604220.
  • Faiz, A, van den Berge, M, Vermeulen, CJ, Ten Hacken, NHT, Guryev, V, Pouwels, SD et al.. AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers. Respir Res. 2019;20 (1):70. doi: 10.1186/s12931-019-1038-6. PubMed PMID:30971245 PubMed Central PMC6456980.
  • Mostaço-Guidolin, LB, Osei, ET, Ullah, J, Hajimohammadi, S, Fouadi, M, Li, X et al.. Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma. Am J Respir Crit Care Med. 2019;200 (4):431-443. doi: 10.1164/rccm.201810-1855OC. PubMed PMID:30950644 .
  • Taylor, DM, Aronow, BJ, Tan, K, Bernt, K, Salomonis, N, Greene, CS et al.. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Dev Cell. 2019;49 (1):10-29. doi: 10.1016/j.devcel.2019.03.001. PubMed PMID:30930166 PubMed Central PMC6616346.
  • Pouwels, SD, Klont, F, Bischoff, R, Ten Hacken, NHT. Confounding Factors Affecting sRAGE as a Biomarker for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019;200 (1):114. doi: 10.1164/rccm.201902-0356LE. PubMed PMID:30888832 PubMed Central PMC6603062.
  • Carpaij, OA, Vonk, JM, Nawijn, MC, Kerstjens, HAM, Koppelman, GH, van den Berge, M et al.. Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies. J Allergy Clin Immunol. 2019;143 (5):1973-1975. doi: 10.1016/j.jaci.2019.01.040. PubMed PMID:30876728 .
  • Faiz, A, Steiling, K, Roffel, MP, Postma, DS, Spira, A, Lenburg, ME et al.. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019;53 (4):. doi: 10.1183/13993003.01202-2018. PubMed PMID:30846474 .
  • Waters, DW, Blokland, KEC, Pathinayake, PS, Wei, L, Schuliga, M, Jaffar, J et al.. STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019;61 (1):61-73. doi: 10.1165/rcmb.2018-0328OC. PubMed PMID:30608861 .
  • Pouwels, SD, Klont, F, Kwiatkowski, M, Wiersma, VR, Faiz, A, van den Berge, M et al.. Reply to Biswas: Acute and Chronic Effects of Cigarette Smoking on sRAGE. Am J Respir Crit Care Med. 2019;199 (6):806-807. doi: 10.1164/rccm.201812-2257LE. PubMed PMID:30589564 PubMed Central PMC6423096.
  • Hulina-Tomašković, A, Heijink, IH, Jonker, MR, Somborac-Bačura, A, Grdić Rajković, M, Rumora, L et al.. Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients. Biochimie. 2019;156 :47-58. doi: 10.1016/j.biochi.2018.09.010. PubMed PMID:30268700 .
  • Schuliga, M, Pechkovsky, DV, Read, J, Waters, DW, Blokland, KEC, Reid, AT et al.. Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts. J Cell Mol Med. 2018;22 (12):5847-5861. doi: 10.1111/jcmm.13855. PubMed PMID:30255990 PubMed Central PMC6237609.
  • Ng-Blichfeldt, JP, Schrik, A, Kortekaas, RK, Noordhoek, JA, Heijink, IH, Hiemstra, PS et al.. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine. 2018;36 :461-474. doi: 10.1016/j.ebiom.2018.09.002. PubMed PMID:30236449 PubMed Central PMC6197151.
  • Post, S, Heijink, IH, Hesse, L, Koo, HK, Shaheen, F, Fouadi, M et al.. Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology. Sci Rep. 2018;8 (1):13275. doi: 10.1038/s41598-018-31500-8. PubMed PMID:30185803 PubMed Central PMC6125431.
  • Pouwels, SD, Klont, F, Kwiatkowski, M, Wiersma, VR, Faiz, A, van den Berge, M et al.. Cigarette Smoking Acutely Decreases Serum Levels of the Chronic Obstructive Pulmonary Disease Biomarker sRAGE. Am J Respir Crit Care Med. 2018;198 (11):1456-1458. doi: 10.1164/rccm.201807-1249LE. PubMed PMID:30130135 .
  • Faiz, A, Heijink, IH, Vermeulen, CJ, Guryev, V, van den Berge, M, Nawijn, MC et al.. Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release. Sci Rep. 2018;8 (1):12426. doi: 10.1038/s41598-018-30602-7. PubMed PMID:30127367 PubMed Central PMC6102306.
  • Tasena, H, Faiz, A, Timens, W, Noordhoek, J, Hylkema, MN, Gosens, R et al.. microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD. Eur Respir J. 2018;52 (3):. doi: 10.1183/13993003.01556-2017. PubMed PMID:30072506 .
  • Nissen, G, Hollaender, H, Tang, FSM, Wegmann, M, Lunding, L, Vock, C et al.. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy. 2018;48 (11):1483-1493. doi: 10.1111/cea.13236. PubMed PMID:30028047 .
  • Faiz, A, Weckmann, M, Tasena, H, Vermeulen, CJ, Van den Berge, M, Ten Hacken, NHT et al.. Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion. Eur Respir J. 2018;52 (2):. doi: 10.1183/13993003.00310-2018. PubMed PMID:29946002 .
  • Billatos, E, Faiz, A, Gesthalter, Y, LeClerc, A, Alekseyev, YO, Xiao, X et al.. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics. 2018;50 (9):705-713. doi: 10.1152/physiolgenomics.00092.2017. PubMed PMID:29932825 PubMed Central PMC6172616.
  • Carpaij, OA, Muntinghe, FOW, Wagenaar, MB, Habing, JW, Timens, W, Kerstjens, HAM et al.. Serum periostin does not reflect type 2-driven inflammation in COPD. Respir Res. 2018;19 (1):112. doi: 10.1186/s12931-018-0818-8. PubMed PMID:29879994 PubMed Central PMC5992772.
  • Hesse, L, Brouwer, U, Petersen, AH, Gras, R, Bosman, L, Brimnes, J et al.. Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma. Clin Exp Allergy. 2018;48 (8):1035-1049. doi: 10.1111/cea.13169. PubMed PMID:29752757 .
  • Kruk, DMLW, Heijink, IH, Slebos, DJ, Timens, W, Ten Hacken, NH. Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon?. Respiration. 2018;96 (2):148-158. doi: 10.1159/000488149. PubMed PMID:29719298 PubMed Central PMC6159827.
  • Waters, DW, Blokland, KEC, Pathinayake, PS, Burgess, JK, Mutsaers, SE, Prele, CM et al.. Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018;315 (2):L162-L172. doi: 10.1152/ajplung.00037.2018. PubMed PMID:29696986 PubMed Central PMC6139657.
  • van den Berge, M, Jonker, MR, Miller-Larsson, A, Postma, DS, Heijink, IH. Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells. Pulm Pharmacol Ther. 2018;50 :47-56. doi: 10.1016/j.pupt.2018.04.002. PubMed PMID:29627483 .
  • Imkamp, K, Berg, M, Vermeulen, CJ, Heijink, IH, Guryev, V, Kerstjens, HAM et al.. Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci. J Allergy Clin Immunol. 2018;142 (1):314-317.e15. doi: 10.1016/j.jaci.2018.01.047. PubMed PMID:29522853 .
  • Dijk, FN, Xu, C, Melén, E, Carsin, AE, Kumar, A, Nolte, IM et al.. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma. Eur Respir J. 2018;51 (3):. doi: 10.1183/13993003.01377-2017. PubMed PMID:29519908 .
  • Jaffar, J, Yang, SH, Kim, SY, Kim, HW, Faiz, A, Chrzanowski, W et al.. Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018;315 (1):L59-L65. doi: 10.1152/ajplung.00030.2018. PubMed PMID:29516782 .
  • Wang, J, Faiz, A, Ge, Q, Vermeulen, CJ, Van der Velden, J, Snibson, KJ et al.. Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling. J Cell Mol Med. 2018;22 (5):2826-2837. doi: 10.1111/jcmm.13576. PubMed PMID:29516637 PubMed Central PMC5908101.
Search PubMed