Research
I have implemented and now lead all snRNA-seq cohort studies in the lab of EXPIRE. This technique helps us to understand the cellular landscape of lung disease and identify novel targets for treatment. I have a PhD in macrophage biology and metabolism and an interest in understanding their interaction with their environment in the context of disease.
https://www.longfonds.nl/nieuws/longfonds-investeert-nieuw-longonderzoek
Keywords: snRNA-seq, macrophage, immunometabolism, COPD and Asthma
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Nehme, J, Maassen, S, Bravaccini, S, Zanoni, M, Gianni, C, De Giorgi, U et al.. Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer. EMBO J. 2025;44 (7):1921-1942. doi: 10.1038/s44318-025-00371-x. PubMed PMID:39930269 PubMed Central PMC11961731. Pouwels, SD, Ter Haar, EAMD, Heijink, IH, Hylkema, MN, Koster, TD, Kuks, PJM et al.. Highlights from the 11th Bronchitis International Symposium: “Heterogeneity of Lung Disease in a Changing Environment,” Groningen, The Netherlands, 2024. Respiration. 2024;103 (12):765-776. doi: 10.1159/000541655. PubMed PMID:39348815 . Warner, H, Franciosa, G, van der Borg, G, Coenen, B, Faas, F, Koenig, C et al.. Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation. Cell Rep. 2024;43 (3):113866. doi: 10.1016/j.celrep.2024.113866. PubMed PMID:38416638 . Maassen, S, Warner, HM, Grijpstra, P, van den Bogaart, G. A quantitative in vitro collagen uptake assay. MethodsX. 2023;11 :102288. doi: 10.1016/j.mex.2023.102288. PubMed PMID:37533791 PubMed Central PMC10392602. Stempels, FC, Jiang, M, Warner, HM, Moser, ML, Janssens, MH, Maassen, S et al.. Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters. J Cell Biol. 2023;222 (7):. doi: 10.1083/jcb.202205130. PubMed PMID:37200023 PubMed Central PMC10200693. Maassen, S, Coenen, B, Dulk, S, van der Werff, M, Warner, H, Spada, F et al.. 5-Ethynyluridine: A Bio-orthogonal Uridine Variant for mRNA-Based Therapies and Vaccines. Chembiochem. 2023;24 (5):e202200658. doi: 10.1002/cbic.202200658. PubMed PMID:36594506 . Maassen, S, Coenen, B, Ioannidis, M, Harber, K, Grijpstra, P, Van den Bossche, J et al.. Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages. Redox Biol. 2023;59 :102591. doi: 10.1016/j.redox.2022.102591. PubMed PMID:36574745 PubMed Central PMC9800195. Bazioti, V, La Rose, AM, Maassen, S, Bianchi, F, de Boer, R, Halmos, B et al.. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice. Nat Commun. 2022;13 (1):3799. doi: 10.1038/s41467-022-31135-4. PubMed PMID:35778407 PubMed Central PMC9249754. Maassen, S, Warner, H, Ioannidis, M, Jansma, J, Markus, H, El Aidy, S et al.. Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages. Free Radic Biol Med. 2022;188 :287-297. doi: 10.1016/j.freeradbiomed.2022.06.235. PubMed PMID:35753585 PubMed Central PMC7614693. Stempels, FC, de Wit, AS, Swierstra, MS, Maassen, S, Bianchi, F, van den Bogaart, G et al.. A sensitive and less cytotoxic assay for identification of proliferating T cells based on bioorthogonally-functionalized uridine analogue. J Immunol Methods. 2022;502 :113228. doi: 10.1016/j.jim.2022.113228. PubMed PMID:35074315 PubMed Central PMC7614694.
Junior investigator longfonds grant (250K)
Stichting asthma bestrijding grant (35K)