Simon D. (Daan) Pouwels
Resume
Assistant Professor, Department of Pulmonary Diseases, University Medical Center Groningen (UMCG), The Netherlands, 2023 –
Post-doctoral project, Department of Pulmonology, University Medical Center Groningen (UMCG), The Netherlands, 2019 –2023
Post-doctoral fellow, University Medical Center Groningen (UMCG), The Netherlands, 2017 – 2019
Post-doctoral project, Department of Analytical Chemistry,University of Groningen, The Netherlands, 2015 – 2017
PhD, cum laude, University of Groningen, The Netherlands, 2017,
Thesis title: DAMPs, endogenous danger signals fueling airway inflammation in COPD.
MSc, Biomedical Sciences, University of Groningen, The Netherlands, 2011
BSc, Medical Biology, University of Groningen, The Netherlands, 2009
Research
My research line focuses on identifying the role of Damage Associated Molecular Patterns (DAMPs) and their receptors in the pathophysiology of COPD, with a special focus on the DAMP receptor RAGE. We analyze levels of panels of DAMPs in various cohorts, investigate the cellular and molecular responses towards COPD triggers, e.g cigarette smoke, as well as investigate the immune reaction which is initiated by DAMPs.
Keywords: COPD, DAMPs, innate immune system, cigarette smoke, biomarkers, cell death, RAGE
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Faiz, A, Mahbub, RM, Boedijono, FS, Tomassen, MI, Kooistra, W, Timens, W et al.. IL-33 Expression Is Lower in Current Smokers at Both Transcriptomic and Protein Level. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202210-1881OC. PubMed PMID:37708400 .
Gupta, A, Burgess, JK, Slebos, DJ, Pouwels, SD. The development, validation, and in vivo testing of a high-precision bronchial epithelial lining fluid sampling device. Front Med (Lausanne). 2023;10 :1172622. doi: 10.3389/fmed.2023.1172622. PubMed PMID:37564050 PubMed Central PMC10410264.
Baalbaki, N, Blankestijn, JM, Abdel-Aziz, MI, de Backer, J, Bazdar, S, Beekers, I et al.. Precision Medicine for More Oxygen (P4O2)-Study Design and First Results of the Long COVID-19 Extension. J Pers Med. 2023;13 (7):. doi: 10.3390/jpm13071060. PubMed PMID:37511673 PubMed Central PMC10381397.
Pouwels, SD, Sigaeva, A, de Boer, S, Eichhorn, IA, Koll, L, Kuipers, J et al.. Host-device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling. J Mater Sci Mater Med. 2023;34 (7):38. doi: 10.1007/s10856-023-06742-2. PubMed PMID:37486435 PubMed Central PMC10366254.
Roodenburg, SA, Pouwels, SD, Klooster, K, Touw, DJ, Slebos, DJ. Endobronchial Valve Treatment Does Not Cause Significant Nickel Deposition in Lung Tissue. Respiration. 2023;102 (6):454-457. doi: 10.1159/000529889. PubMed PMID:37231891 .
Pouwels, SD, van den Berge, M, Vasse, GF, Timens, W, Brandsma, CA, Aliee, H et al.. Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium. Respir Res. 2023;24 (1):130. doi: 10.1186/s12931-023-02430-5. PubMed PMID:37170105 PubMed Central PMC10174605.
Kole, TM, Pouwels, SD, Bults, R, Ketelaar, ME, Guryev, V, Koll, L et al.. Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms. ERJ Open Res. 2023;9 (2):. doi: 10.1183/23120541.00413-2022. PubMed PMID:37020836 PubMed Central PMC10068516.
Blokland, KEC, Nizamoglu, M, Habibie, H, Borghuis, T, Schuliga, M, Melgert, BN et al.. Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts. Front Pharmacol. 2022;13 :989169. doi: 10.3389/fphar.2022.989169. PubMed PMID:36408252 PubMed Central PMC9673045.
Joglekar, MM, Nizamoglu, M, Fan, Y, Nemani, SSP, Weckmann, M, Pouwels, SD et al.. Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases. Front Pharmacol. 2022;13 :995051. doi: 10.3389/fphar.2022.995051. PubMed PMID:36408219 PubMed Central PMC9669433.
Wiersma, VR, Hoonhorst, SJM, Ten Hacken, NHT, van den Berge, M, Slebos, DJ, Pouwels, SD et al.. The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils. Lung. 2022;200 (6):687-690. doi: 10.1007/s00408-022-00585-4. PubMed PMID:36282357 PubMed Central PMC9675764.
Search PubMed2022 ZonMW Open Competition grant, €766,319.- (co-applicant)
2022 ZonMW VENI grant, personal grant, €280,000.- (main applicant)
2021 UMCG Public Private Partnership allowance grant, €445,720.- (main applicant)
2021 UTS Sydney – Cross Disciplinary Research Grant 2021, $30,000.- (co-applicant)
2021 P4O2 – Precision medicine for more Oxygen, €14,500,000.- (co-applicant)
2020 P4O2 COVID-19 grant, €2,000,000.- (co-applicant)
2016 Noordelijke CARA Stichting, Research Grant, €4,500.-
2016 The Dutch Lung Foundation, Young Investigator Grant, €200,000.-
2015 J.C. de Cock Foundation, Research Grant, €4,000.-
2014 J.C. de Cock Foundation, Research Grant, €4,000.-
2013 Stichting Astma Bestrijding Research Grant, €13,000.-
2023 American Thoracic Society Ann Woolcock Memorial Award, $500.-
2022 American Thoracic Society Rising Stars of Research Award, $500.-
2022 HTRIC Research Award 2022, €260,000.-
2019 SAB Best Paper Award, €2,500.-
2018 ERS Young Scientist Sponsorship, €600.-
2017 NVVI Van Bekkum Best Thesis Award, €1,000.-
2017 KNG Van Swinderen Thesis Award 2nd price, €1,000.-
2017 2017 ATS Washington, Abstract Scholarship, RCMB Assembly, $500.-
2015 Abstract scholarship, National Emphysema Foundation, ATS Denver, $500.-
2013 ERS travel grant, 11th ERS Lung Science Conference, Estoril, Portugal, €550.-
2013 NRS Young Investigator Travel Grant, 15th ICI, Milan, Italy, €1,250.-
2013 ECDO best abstract travel grant, 21st ECDO, Paris, France, €500.-
2013 Chiési NRS Young Investigator Award, €5,000.-
2013 Immunotools Special Award, €1,000.-