Simon D. (Daan) Pouwels

Simon D. (Daan) Pouwels

Post-doctoral Researcher

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Resume

Post-doctoral project, Department of Pulmonology, University Medical Center Groningen (UMCG),  The Netherlands, 2019 –

Post-doctoral fellow, University Medical Center Groningen (UMCG), The Netherlands, 2017 – 2019

Post-doctoral project, Department of Analytical Chemistry,University of Groningen,  The Netherlands, 2015 – 2017

PhD, cum laude, University of Groningen,  The Netherlands, 2017, 

Thesis title: DAMPs, endogenous danger signals fueling airway inflammation in COPD.

MSc, Biomedical Sciences, University of Groningen,  The Netherlands, 2011

BSc,  Medical Biology, University of Groningen, The Netherlands, 2009

Research

My research line focuses on identifying the role of Damage Associated Molecular Patterns (DAMPs) and their receptors in the pathophysiology of COPD, with a special focus on the DAMP receptor RAGE. We analyze levels of panels of DAMPs in various cohorts, investigate the cellular and molecular responses towards COPD triggers, e.g cigarette smoke, as well as investigate the immune reaction which is initiated by DAMPs.

Keywords: COPD, DAMPs, innate immune system, cigarette smoke, biomarkers, cell death, RAGE

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Roodenburg, SA, Pouwels, SD, Klooster, K, Touw, DJ, Slebos, DJ. Endobronchial Valve Treatment Does Not Cause Significant Nickel Deposition in Lung Tissue. Respiration. 2023; :1-4. doi: 10.1159/000529889. PubMed PMID:37231891 .

Pouwels, SD, van den Berge, M, Vasse, GF, Timens, W, Brandsma, CA, Aliee, H et al.. Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium. Respir Res. 2023;24 (1):130. doi: 10.1186/s12931-023-02430-5. PubMed PMID:37170105 PubMed Central PMC10174605.

Kole, TM, Pouwels, SD, Bults, R, Ketelaar, ME, Guryev, V, Koll, L et al.. Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms. ERJ Open Res. 2023;9 (2):. doi: 10.1183/23120541.00413-2022. PubMed PMID:37020836 PubMed Central PMC10068516.

Blokland, KEC, Nizamoglu, M, Habibie, H, Borghuis, T, Schuliga, M, Melgert, BN et al.. Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts. Front Pharmacol. 2022;13 :989169. doi: 10.3389/fphar.2022.989169. PubMed PMID:36408252 PubMed Central PMC9673045.

Joglekar, MM, Nizamoglu, M, Fan, Y, Nemani, SSP, Weckmann, M, Pouwels, SD et al.. Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases. Front Pharmacol. 2022;13 :995051. doi: 10.3389/fphar.2022.995051. PubMed PMID:36408219 PubMed Central PMC9669433.

Wiersma, VR, Hoonhorst, SJM, Ten Hacken, NHT, van den Berge, M, Slebos, DJ, Pouwels, SD et al.. The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils. Lung. 2022;200 (6):687-690. doi: 10.1007/s00408-022-00585-4. PubMed PMID:36282357 PubMed Central PMC9675764.

Klont, F, Horvatovich, P, Bowler, RP, van Rikxoort, E, Charbonnier, JP, Kwiatkowski, M et al.. Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans. Respir Res. 2022;23 (1):15. doi: 10.1186/s12931-022-01934-w. PubMed PMID:35073932 PubMed Central PMC8785488.

Gupta, A, Burgess, JK, Borghuis, T, de Vries, MP, Kuipers, J, Permentier, HP et al.. Identification of damage associated molecular patterns and extracellular matrix proteins as major constituents of the surface proteome of lung implantable silicone/nitinol devices. Acta Biomater. 2022;141 :209-218. doi: 10.1016/j.actbio.2022.01.016. PubMed PMID:35038586 .

Wiersma, VR, Pouwels, SD. An Integrative Genomic Strategy Identifies Soluble Receptor for Advanced Glycation End-Products as a Causal and Protective Biomarker of Lung Function. Chest. 2022;161 (1):3-5. doi: 10.1016/j.chest.2021.08.005. PubMed PMID:35000706 .

Joglekar, MM, Slebos, DJ, Leijten, J, Burgess, JK, Pouwels, SD. Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction. Eur Respir Rev. 2021;30 (162):. doi: 10.1183/16000617.0142-2021. PubMed PMID:34853096 PubMed Central PMC9488910.

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2019               Noordelijke CARA Stichting, Research Grant, €5,000.-

2016               Noordelijke CARA Stichting, Research Grant, €4,500.-

2016               The Dutch Lung Foundation, Young Investigator Grant, €200,000.-

2015               J.C. de Cock Foundation, Research Grant, €4,000.-

2014                J.C. de Cock Foundation, Research Grant, €4,000.-

2013                Stichting Astma Bestrijding Research Grant, €13,000.-

2019               SAB Best Paper Award, €2,500.-

2018               ERS Young Scientist Sponsorship, €600.-

2017               NVVI Van Bekkum Best Thesis Award, €1,000.-

2017               KNG Van Swinderen Thesis Award 2nd price,  €1,000.-

2017               2017 ATS Washington, Abstract Scholarship, RCMB Assembly, $500.-

2015               Abstract scholarship, National Emphysema Foundation, ATS Denver, $500.-

2013                ERS travel grant, 11th ERS Lung Science Conference, Estoril, Portugal, €550.-

2013                NRS Young Investigator Travel Grant, 15th ICI, Milan, Italy, €1,250.-

2013                ECDO best abstract travel grant, 21st ECDO, Paris, France, €500.-

2013                Chiési NRS Young Investigator Award, €5,000.-

2013                Immunotools Special Award, €1,000.-