Simon D. (Daan) Pouwels

Post-doctoral Researcher

Resume

Post-doctoral project, Department of Pulmonology, University Medical Center Groningen (UMCG),  The Netherlands, 2019 –

Post-doctoral fellow, University Medical Center Groningen (UMCG), The Netherlands, 2017 – 2019

Post-doctoral project, Department of Analytical Chemistry,University of Groningen,  The Netherlands, 2015 – 2017

PhD, cum laude, University of Groningen,  The Netherlands, 2017, 

Thesis title: DAMPs, endogenous danger signals fueling airway inflammation in COPD.

MSc, Biomedical Sciences, University of Groningen,  The Netherlands, 2011

BSc,  Medical Biology, University of Groningen, The Netherlands, 2009

Research

My research line focuses on identifying the role of Damage Associated Molecular Patterns (DAMPs) and their receptors in the pathophysiology of COPD, with a special focus on the DAMP receptor RAGE. We analyze levels of panels of DAMPs in various cohorts, investigate the cellular and molecular responses towards COPD triggers, e.g cigarette smoke, as well as investigate the immune reaction which is initiated by DAMPs.

Keywords: COPD, DAMPs, innate immune system, cigarette smoke, biomarkers, cell death, RAGE

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Kruk, DMLW, Wisman, M, Noordhoek, JA, Nizamoglu, M, Jonker, MR, de Bruin, HG et al.. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells. Cells. 2021;10 (11):. doi: 10.3390/cells10112860. PubMed PMID:34831082 .

Pouwels, SD, Burgess, JK, Verschuuren, E, Slebos, DJ. The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus. Respir Res. 2021;22 (1):285. doi: 10.1186/s12931-021-01882-x. PubMed PMID:34736473 PubMed Central PMC8570005.

Klont, F, Kwiatkowski, M, Faiz, A, van den Bosch, T, Pouwels, SD, Dekker, FJ et al.. Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows. J Proteome Res. 2021;20 (11):5218-5221. doi: 10.1021/acs.jproteome.1c00623. PubMed PMID:34669399 PubMed Central PMC8576839.

Pouwels, SD, Hesse, L, Wu, X, Allam, VSRR, van Oldeniel, D, Bhiekharie, LJ et al.. LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE. Am J Physiol Lung Cell Mol Physiol. 2021;321 (4):L641-L652. doi: 10.1152/ajplung.00138.2021. PubMed PMID:34405719 .

Roodenburg, SA, Pouwels, SD, Slebos, DJ. Airway granulation response to lung-implantable medical devices: a concise overview. Eur Respir Rev. 2021;30 (161):. doi: 10.1183/16000617.0066-2021. PubMed PMID:34348981 .

Blokland, KEC, Habibie, H, Borghuis, T, Teitsma, GJ, Schuliga, M, Melgert, BN et al.. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM. Cells. 2021;10 (7):. doi: 10.3390/cells10071628. PubMed PMID:34209854 PubMed Central PMC8307656.

Faiz, A, Rathnayake, SNH, Ten Hacken, NHT, Guryev, V, van den Berge, M, Pouwels, SD et al.. Single-nucleotide polymorphism rs2070600 regulates AGER splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products. ERJ Open Res. 2021;7 (2):. doi: 10.1183/23120541.00947-2020. PubMed PMID:34195255 PubMed Central PMC8236754.

Pratte, KA, Curtis, JL, Kechris, K, Couper, D, Cho, MH, Silverman, EK et al.. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res. 2021;22 (1):127. doi: 10.1186/s12931-021-01686-z. PubMed PMID:33906653 PubMed Central PMC8076883.

Heijink, IH, Hackett, TL, Pouwels, SD. Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium. J Pathol. 2021;253 (4):351-354. doi: 10.1002/path.5607. PubMed PMID:33368245 PubMed Central PMC7986690.

Blokland, KEC, Pouwels, SD, Schuliga, M, Knight, DA, Burgess, JK. Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases. Clin Sci (Lond). 2020;134 (20):2681-2706. doi: 10.1042/CS20190893. PubMed PMID:33084883 PubMed Central PMC7578566.

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2019               Noordelijke CARA Stichting, Research Grant, €5,000.-

2016               Noordelijke CARA Stichting, Research Grant, €4,500.-

2016               The Dutch Lung Foundation, Young Investigator Grant, €200,000.-

2015               J.C. de Cock Foundation, Research Grant, €4,000.-

2014                J.C. de Cock Foundation, Research Grant, €4,000.-

2013                Stichting Astma Bestrijding Research Grant, €13,000.-

2019               SAB Best Paper Award, €2,500.-

2018               ERS Young Scientist Sponsorship, €600.-

2017               NVVI Van Bekkum Best Thesis Award, €1,000.-

2017               KNG Van Swinderen Thesis Award 2nd price,  €1,000.-

2017               2017 ATS Washington, Abstract Scholarship, RCMB Assembly, $500.-

2015               Abstract scholarship, National Emphysema Foundation, ATS Denver, $500.-

2013                ERS travel grant, 11th ERS Lung Science Conference, Estoril, Portugal, €550.-

2013                NRS Young Investigator Travel Grant, 15th ICI, Milan, Italy, €1,250.-

2013                ECDO best abstract travel grant, 21st ECDO, Paris, France, €500.-

2013                Chiési NRS Young Investigator Award, €5,000.-

2013                Immunotools Special Award, €1,000.-