Janette K. Burgess
Janette Burgess is Professor of Extracellular Matrix in Disease Pathogenesis within the Department of Pathology and Medical Biology, Medical Biology section at University Medical Center Groningen, the Netherlands. Janette completed her Bachelor of Science (with honours) at the University of Adelaide in 1991 and her PhD at the University of New South Wales in 1998. In 1999 she was appointed to a Post-doctoral position at the University of Sydney under the guidance of Prof Judy Black. She has been awarded a National Health and Medical Research Council (NHMRC) (Australia) Peter Doherty training award (2000-2006), NHMRC R.D Wright Career Development Award (2006-2011) and a NHMRC Career Development Fellowship level 2 (2012-2015). In 2003 Janette was awarded the Ann Woolcock Young Investigator award by the Thoracic Society of Australia and New Zealand and in 2007 The American Thoracic Society awarded her the Ann Woolcock Memorial Award. She recently completed a Rosalind Franklin Fellow, awarded by the University of Groningen and the European Union (2015-2020).
Janette’s research focusses on the role of the extracellular matrix (ECM) in lung pathology. She is intrigued by the changes in the tissue and airway structures of the lungs that occur during disease development and progression and wants to know if these changes are a cause or a consequence of the pathology. Working with primary human lung cells, human lung tissue samples and patient clinical information, the research seeks to characterize the changes in the ECM that occur during disease in the lungs and to understand the mechanisms that underlie these changes. By novel in vitro cell models, ex vivo human lung tissue models and advanced microscopy imaging techniques she is unraveling the complex nature of the regulation of the ECM and exploring its potential as a future target for therapeutic intervention. This research links basic science to the goals of prevention and treatment of human lung diseases that afflict millions of people worldwide.
Pouwels, SD, Burgess, JK, Verschuuren, E, Slebos, DJ. The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus. Respir Res. 2021;22 (1):285. doi: 10.1186/s12931-021-01882-x. PubMed PMID:34736473 PubMed Central PMC8570005.
Martinez-Garcia, FD, de Hilster, RHJ, Sharma, PK, Borghuis, T, Hylkema, MN, Burgess, JK et al.. Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels. Polymers (Basel). 2021;13 (18):. doi: 10.3390/polym13183113. PubMed PMID:34578013 PubMed Central PMC8470996.
Martinez-Garcia, FD, Valk, MM, Sharma, PK, Burgess, JK, Harmsen, MC. Adipose Tissue-Derived Stromal Cells Alter the Mechanical Stability and Viscoelastic Properties of Gelatine Methacryloyl Hydrogels. Int J Mol Sci. 2021;22 (18):. doi: 10.3390/ijms221810153. PubMed PMID:34576318 PubMed Central PMC8468163.
Waters, DW, Schuliga, M, Pathinayake, PS, Wei, L, Tan, HY, Blokland, KEC et al.. A Senescence Bystander Effect in Human Lung Fibroblasts. Biomedicines. 2021;9 (9):. doi: 10.3390/biomedicines9091162. PubMed PMID:34572347 PubMed Central PMC8470192.
Schuliga, M, Kanwal, A, Read, J, Blokland, KEC, Burgess, JK, Prêle, CM et al.. A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF. Am J Physiol Lung Cell Mol Physiol. 2021;321 (5):L859-L871. doi: 10.1152/ajplung.00574.2020. PubMed PMID:34524912 .
Vasse, GF, Van Os, L, De Jager, M, Jonker, MR, Borghuis, T, Van Den Toorn, LT et al.. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices. Front Pharmacol. 2021;12 :669037. doi: 10.3389/fphar.2021.669037. PubMed PMID:34393771 PubMed Central PMC8355988.
Weckmann, M, Bahmer, T, Bülow Sand, JM, Rank Rønnow, S, Pech, M, Vermeulen, C et al.. COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J. 2021; :. doi: 10.1183/13993003.03969-2020. PubMed PMID:34326188 .
Blokland, KEC, Habibie, H, Borghuis, T, Teitsma, GJ, Schuliga, M, Melgert, BN et al.. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM. Cells. 2021;10 (7):. doi: 10.3390/cells10071628. PubMed PMID:34209854 PubMed Central PMC8307656.
Faiz, A, Harkness, LM, Tjin, G, Bernal, V, Horvatovich, P, James, A et al.. Angiogenic regulatory influence of extracellular matrix deposited by resting state asthmatic and non-asthmatic airway smooth muscle cells is similar. J Cell Mol Med. 2021; :. doi: 10.1111/jcmm.16648. PubMed PMID:34146379 PubMed Central PMC8256353.
Nemani, SSP, Vermeulen, CJ, Pech, M, Faiz, A, Oliver, BGG, van den Berge, M et al.. COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding. ERJ Open Res. 2021;7 (2):. doi: 10.1183/23120541.00802-2020. PubMed PMID:34109240 PubMed Central PMC8181658.Search PubMed
2015 – 2020 Rosalind Franklin Fellowship, University of Groningen & European Union
2014 Lung Foundation Australia/Lizotte Family Research Award for Interstitial Pulmonary Fibrosis Research
2012 17th International Colloquium on Lung and Airways Fibrosis Young Investigator Award
2012 – 2015 National Health and Medical Research Council Career Development Fellowship Level 2
2007 The American Thoracic Society Ann Woolcock Memorial Award
2006 – 2011 National Health and Medical Research Council R. Douglas Wright Career Development Award
2005 NSW Young Tall Poppy Award Australian Institute of Political Sciences
2004 Inaugural Rebecca L Cooper Award Institute of Biomedical Sciences, University of Sydney
2004 The Denis Wade New Investigator Award (Australian Society of Clinical and Experimental Pharmacologists and Toxicologists
2003 Finalist Fresh Science. (Young Scientists presenting their research to the media during Science Week)
2003 The Ann Woolcock Young Investigator Award, The Thoracic Society of Australia and New Zealand
2002 The ASMR NSW Branch Johnson & Johnson Research Postdoctoral Prize
2001 National Health and Medical Research Council Industry Fellowship (declined in lieu of above)
2001 – 2004 National Health and Medical Research Council Peter Doherty Fellowship (deferred for 12 months)
1997 The Speywood Medal – Highly Commended, The Australasian Society of Thrombosis and Haemostasis (Young Investigator Award)
1997 The Baikie Award, Haematology Society of Australia (Young Investigator Award)
1995 The Australian Vascular Biology Society Young Investigator Award