Janette K. Burgess
Janette Burgess is Professor of Extracellular Matrix in Disease Pathogenesis within the Department of Pathology and Medical Biology, Medical Biology section at University Medical Center Groningen, the Netherlands. Janette completed her Bachelor of Science (with honours) at the University of Adelaide in 1991 and her PhD at the University of New South Wales in 1998. In 1999 she was appointed to a Post-doctoral position at the University of Sydney under the guidance of Prof Judy Black. She has been awarded a National Health and Medical Research Council (NHMRC) (Australia) Peter Doherty training award (2000-2006), NHMRC R.D Wright Career Development Award (2006-2011) and a NHMRC Career Development Fellowship level 2 (2012-2015). In 2003 Janette was awarded the Ann Woolcock Young Investigator award by the Thoracic Society of Australia and New Zealand and in 2007 The American Thoracic Society awarded her the Ann Woolcock Memorial Award. She recently completed a Rosalind Franklin Fellow, awarded by the University of Groningen and the European Union (2015-2020).
Janette’s research focusses on the role of the extracellular matrix (ECM) in lung pathology. She is intrigued by the changes in the tissue and airway structures of the lungs that occur during disease development and progression and wants to know if these changes are a cause or a consequence of the pathology. Working with primary human lung cells, human lung tissue samples and patient clinical information, the research seeks to characterize the changes in the ECM that occur during disease in the lungs and to understand the mechanisms that underlie these changes. By novel in vitro cell models, ex vivo human lung tissue models and advanced microscopy imaging techniques she is unraveling the complex nature of the regulation of the ECM and exploring its potential as a future target for therapeutic intervention. This research links basic science to the goals of prevention and treatment of human lung diseases that afflict millions of people worldwide.
Nizamoglu, M, de Hilster, RHJ, Zhao, F, Sharma, PK, Borghuis, T, Harmsen, MC et al.. An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition. Acta Biomater. 2022; :. doi: 10.1016/j.actbio.2022.05.031. PubMed PMID:35605955 .
Rønnow, SR, Sand, JMB, Staunstrup, LM, Bahmer, T, Wegmann, M, Lunding, L et al.. A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype. Asthma Res Pract. 2022;8 (1):2. doi: 10.1186/s40733-022-00084-6. PubMed PMID:35418159 PubMed Central PMC9006548.
Benam, KH, Burgess, JK, Stewart, AG. Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models. Front Pharmacol. 2021;12 :827172. doi: 10.3389/fphar.2021.827172. PubMed PMID:35046832 PubMed Central PMC8762276.
Gupta, A, Burgess, JK, Borghuis, T, de Vries, MP, Kuipers, J, Permentier, HP et al.. Identification of damage associated molecular patterns and extracellular matrix proteins as major constituents of the surface proteome of lung implantable silicone/nitinol devices. Acta Biomater. 2022;141 :209-218. doi: 10.1016/j.actbio.2022.01.016. PubMed PMID:35038586 .
Dekkers, BGJ, Saad, SI, van Spelde, LJ, Burgess, JK. Basement membranes in obstructive pulmonary diseases. Matrix Biol Plus. 2021;12 :100092. doi: 10.1016/j.mbplus.2021.100092. PubMed PMID:34877523 PubMed Central PMC8632995.
Joglekar, MM, Slebos, DJ, Leijten, J, Burgess, JK, Pouwels, SD. Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction. Eur Respir Rev. 2021;30 (162):. doi: 10.1183/16000617.0142-2021. PubMed PMID:34853096 .
Pouwels, SD, Burgess, JK, Verschuuren, E, Slebos, DJ. The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus. Respir Res. 2021;22 (1):285. doi: 10.1186/s12931-021-01882-x. PubMed PMID:34736473 PubMed Central PMC8570005.
Martinez-Garcia, FD, de Hilster, RHJ, Sharma, PK, Borghuis, T, Hylkema, MN, Burgess, JK et al.. Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels. Polymers (Basel). 2021;13 (18):. doi: 10.3390/polym13183113. PubMed PMID:34578013 PubMed Central PMC8470996.
Martinez-Garcia, FD, Valk, MM, Sharma, PK, Burgess, JK, Harmsen, MC. Adipose Tissue-Derived Stromal Cells Alter the Mechanical Stability and Viscoelastic Properties of Gelatine Methacryloyl Hydrogels. Int J Mol Sci. 2021;22 (18):. doi: 10.3390/ijms221810153. PubMed PMID:34576318 PubMed Central PMC8468163.Search PubMed
2015 – 2020 Rosalind Franklin Fellowship, University of Groningen & European Union
2014 Lung Foundation Australia/Lizotte Family Research Award for Interstitial Pulmonary Fibrosis Research
2012 17th International Colloquium on Lung and Airways Fibrosis Young Investigator Award
2012 – 2015 National Health and Medical Research Council Career Development Fellowship Level 2
2007 The American Thoracic Society Ann Woolcock Memorial Award
2006 – 2011 National Health and Medical Research Council R. Douglas Wright Career Development Award
2005 NSW Young Tall Poppy Award Australian Institute of Political Sciences
2004 Inaugural Rebecca L Cooper Award Institute of Biomedical Sciences, University of Sydney
2004 The Denis Wade New Investigator Award (Australian Society of Clinical and Experimental Pharmacologists and Toxicologists
2003 Finalist Fresh Science. (Young Scientists presenting their research to the media during Science Week)
2003 The Ann Woolcock Young Investigator Award, The Thoracic Society of Australia and New Zealand
2002 The ASMR NSW Branch Johnson & Johnson Research Postdoctoral Prize
2001 National Health and Medical Research Council Industry Fellowship (declined in lieu of above)
2001 – 2004 National Health and Medical Research Council Peter Doherty Fellowship (deferred for 12 months)
1997 The Speywood Medal – Highly Commended, The Australasian Society of Thrombosis and Haemostasis (Young Investigator Award)
1997 The Baikie Award, Haematology Society of Australia (Young Investigator Award)
1995 The Australian Vascular Biology Society Young Investigator Award