Kaj Eric Cornelis Blokland

Resume

PhD Candidate, University of Groningen, The Netherlands, 2016 –

PhD Candidate, University of Newcastle, Australia, 2016 –

Research Assistant, Paul-Ehrlich-Institut, Germany, January 2016 –  June 2016

MSc,  Regenerative Medicine & Technology, University of Utrecht, The Netherlands, 2016

BSc, Saxion University of Applied Sciences, The Netherlands, 2013

 

Research

My research line focuses on identifying the role of fibroblast senescence in Idiopathic Pulmonary Fibrosis. The first two years at the University of Newcastle, Australia focused on the fibroblast-epithelial crosstalk and how this contributes to fibrosis. The last two years at the University of Groningen is focusing on how the fibrotic ECM contributes to fibroblast senescence.

Waters, DW, Schuliga, M, Pathinayake, PS, Wei, L, Tan, HY, Blokland, KEC et al.. A Senescence Bystander Effect in Human Lung Fibroblasts. Biomedicines. 2021;9 (9):. doi: 10.3390/biomedicines9091162. PubMed PMID:34572347 PubMed Central PMC8470192.

Schuliga, M, Kanwal, A, Read, J, Blokland, KEC, Burgess, JK, Prêle, CM et al.. A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF. Am J Physiol Lung Cell Mol Physiol. 2021;321 (5):L859-L871. doi: 10.1152/ajplung.00574.2020. PubMed PMID:34524912 .

Blokland, KEC, Habibie, H, Borghuis, T, Teitsma, GJ, Schuliga, M, Melgert, BN et al.. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM. Cells. 2021;10 (7):. doi: 10.3390/cells10071628. PubMed PMID:34209854 PubMed Central PMC8307656.

Blokland, KEC, Pouwels, SD, Schuliga, M, Knight, DA, Burgess, JK. Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases. Clin Sci (Lond). 2020;134 (20):2681-2706. doi: 10.1042/CS20190893. PubMed PMID:33084883 PubMed Central PMC7578566.

Blokland, KEC, Waters, DW, Schuliga, M, Read, J, Pouwels, SD, Grainge, CL et al.. Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing. Pharmaceutics. 2020;12 (4):. doi: 10.3390/pharmaceutics12040389. PubMed PMID:32344567 PubMed Central PMC7238173.

Schuliga, M, Read, J, Blokland, KEC, Waters, DW, Burgess, J, Prêle, C et al.. Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner. Clin Sci (Lond). 2020;134 (7):889-905. doi: 10.1042/CS20191160. PubMed PMID:32219338 .

McVey, MJ, Maishan, M, Blokland, KEC, Bartlett, N, Kuebler, WM. Extracellular vesicles in lung health, disease, and therapy. Am J Physiol Lung Cell Mol Physiol. 2019;316 (6):L977-L989. doi: 10.1152/ajplung.00546.2018. PubMed PMID:30892076 .

Waters, DW, Blokland, KEC, Pathinayake, PS, Wei, L, Schuliga, M, Jaffar, J et al.. STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019;61 (1):61-73. doi: 10.1165/rcmb.2018-0328OC. PubMed PMID:30608861 .

Cullmann, K, Blokland, KEC, Sebe, A, Schenk, F, Ivics, Z, Heinz, N et al.. Sustained and regulated gene expression by Tet-inducible “all-in-one” retroviral vectors containing the HNRPA2B1-CBX3 UCOE®. Biomaterials. 2019;192 :486-499. doi: 10.1016/j.biomaterials.2018.11.006. PubMed PMID:30508767 .

Schuliga, M, Pechkovsky, DV, Read, J, Waters, DW, Blokland, KEC, Reid, AT et al.. Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts. J Cell Mol Med. 2018;22 (12):5847-5861. doi: 10.1111/jcmm.13855. PubMed PMID:30255990 PubMed Central PMC6237609.

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2020               De Cock-Hadders Foundation research Grant

2019               Centre of research Excellence in pulmonary fibrosis CREATE Travel Grant for ERS 2019

2018               Centre of research Excellence in pulmonary fibrosis CREATE Travel Grant for TSANZ 2018

 

2017               First prize for best abstract presentation in parenchymal lung disease at the TSANZ NSW/ACT Branch Meeting October,  2017