· Postdoctoralvresearcher, Department of Pathology and Medical Biology, University Medical
Center Groningen, the Netherlands, 2022–
· PhD, Department of Pharmaceutical Science, Utrecht University, the Netherlands,
· MSc, Department of Pharmaceutical Science, Jilin University, China, 2014-2017
My research is focus on investigating a novel regenerative treatment aimed at facilitating the repair of lung tissue in Chronic Obstructive Pulmonary Disease (COPD). A pivotal component in this repairing process is using Mesenchymal Stromal/Stem Cells (MSCs), which play a fundamental role in supporting the regeneration of alveolar structures through the differentiation of progenitor cells, primarily mediated by paracrine mechanisms.
The approach to achieving tissue repair involves the innovative application of nanoparticles encapsulated within micrometer-thin hydrogels, referred to as “nano-in-microgels.” This innovative technology offers a mechanism for the targeted delivery of crucial factors to the alveoli, enabling controlled and sustained release over a defined period. Through this intervention, we aim to restore and enhance the regenerative capabilities of lung-resident MSCs, thereby contributing to the reestablishment of functional lung tissue in COPD.
Keywords: COPD, MSCs, 3D cultures, Nanoparticles
Lei Wang, Yang Cai, Johan Garssen, P.A.J. Henricks, Gert Folkerts, Saskia Braber. The Gut-lung axis in COPD. Am J Respir Crit Care Med. 2023. doi: 10.1164/rccm.202206-1066TR
Lei Wang, Lieke E.J. van lersel, Charlotte E. Pelgrim, Jingyi Lu, Ingrid van Ark, Thea Leusink-Muis, Harry R. Gosker, Ramon C.J. Langen, Annemie M.W.J. Schols, Josep Argilés, Ardy van Helvoort, Aletta D. Kraneveld, Johan Garssen, P.A.J. Henricks, Gert Folkerts, Saskia Braber. Fat mass loss and adipose atrophy in a murine model of cigarette smoke-induced COPD. Cells. 2022. 11(18). doi: 10.3390/cells11182893.
Lei Wang†, Charlotte E. Pelgrim†, Lucía N. Peralta Marzal, Stephanie Korver, Ingrid van Ark, Thea Leusink-Muis, Ardy van Helvoort, Ali Keshavarzian, Aletta D. Kraneveld, Johan Garssen, P.A.J. Henricks, Gert Folkerts, Saskia Braber. Changes in intestinal homeostasis and immunity in a cigarette smoke- and LPS-induced murine model for COPD: the lung-gut axis. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 14. doi: 10.1152/ajplung.00486.2021.
Charlotte E. Pelgrim†, Lei Wang†, Lucía N. Peralta Marzal, Stephanie Korver, Ingrid van Ark, Thea Leusink-Muis, Saskia Braber, Gert Folkerts, Johan Garssen, Ardy van Helvoort, Aletta D. Kraneveld. Increased exploration and hyperlocomotion in a cigarette smoke and LPS induced murine model of COPD: linking pulmonary and systemic inflammation with the brain. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 14. doi: 10.1152/ajplung.00485.2021.
Wang, Lei, Charlotte Pelgrim, Daniël Swart, Guido Krenning, Adrianus C. van der Graaf, Aletta D. Kraneveld, Thea Leusink-Muis, Ingrid van Ark, Johan Garssen, Gert Folkerts and Saskia Braber. SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure. International journal of molecular sciences 22.9 (2021): 4991.
Lei Wang, Pim J. Koelink, Johan Garssen, P.A.J. Henricks, Gert Folkerts, Saskia Braber. Transcriptomic changes in lung and intestinal tissues of cigarette smoke-exposed mice compared to COPD and CD patient data sets (Under revision)