Marijn Berg

Resume

Bioinformatics PhD Candidate, Department of Pathology and Medical Biology, University Medical Center Groningen (UMCG),  The Netherlands, 2019

Bioinformatics analysist, Department of Pathology and Medical Biology, University Medical Center Groningen (UMCG),  The Netherlands,  2017 2019

BSc Bioinformatics, Hanze University of Applied Sciences, The Netherlands, 2017

 

Research

I’m interested in the differences in the cellular landscape of the airway epithelium between healthy, asthmatic and asthma remission populations. To look at those differences I analyze single cell RNA-sequencing data from bronchial biopsies. These data can be used to computationally identify cell types and states based on their transcriptional profile and those can be compared between the groups.
The first results of this have already been published in Nature Medicine where we showed some interesting differences in the relative cell populations and cell type interactions in asthmatic individuals compared to controls.
We’re currently adding more samples to our data which also includes asthma remission groups. Now that we have more data, improved methods to analyze them and an increasing expertise in interpreting these results and placing them into the broader context of the fields of scRNA-sequencing technologies and airway diseases there are doubtless interesting results coming in the future.

van de Wetering, C, Elko, E, Berg, M, Schiffers, CHJ, Stylianidis, V, van den Berge, M et al.. Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?. Redox Biol. 2021;43 :101995. doi: 10.1016/j.redox.2021.101995. PubMed PMID:33979767 PubMed Central PMC8131726.

Dwyer, DF, Ordovas-Montanes, J, Allon, SJ, Buchheit, KM, Vukovic, M, Derakhshan, T et al.. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021;6 (56):. doi: 10.1126/sciimmunol.abb7221. PubMed PMID:33637594 PubMed Central PMC8362933.

Pouwels, SD, Wiersma, VR, Fokkema, IE, Berg, M, Ten Hacken, NHT, van den Berge, M et al.. Acute cigarette smoke-induced eQTL affects formyl peptide receptor expression and lung function. Respirology. 2021;26 (3):233-240. doi: 10.1111/resp.13960. PubMed PMID:33078507 PubMed Central PMC7983955.

Jiang, J, Faiz, A, Berg, M, Carpaij, OA, Vermeulen, CJ, Brouwer, S et al.. Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma. Clin Exp Allergy. 2020;50 (12):1428-1431. doi: 10.1111/cea.13732. PubMed PMID:32935368 PubMed Central PMC7756890.

Burgess, JK, Jonker, MR, Berg, M, Ten Hacken, NTH, Meyer, KB, van den Berge, M et al.. Periostin: contributor to abnormal airway epithelial function in asthma?. Eur Respir J. 2021;57 (2):. doi: 10.1183/13993003.01286-2020. PubMed PMID:32907887 .

Sungnak, W, Huang, N, Bécavin, C, Berg, M, HCA Lung Biological Network. SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways. ArXiv. 2020; :. . PubMed PMID:32550242 PubMed Central PMC7280877.

Sungnak, W, Huang, N, Bécavin, C, Berg, M, Queen, R, Litvinukova, M et al.. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26 (5):681-687. doi: 10.1038/s41591-020-0868-6. PubMed PMID:32327758 .

Qi, C, Jiang, Y, Yang, IV, Forno, E, Wang, T, Vonk, JM et al.. Nasal DNA methylation profiling of asthma and rhinitis. J Allergy Clin Immunol. 2020;145 (6):1655-1663. doi: 10.1016/j.jaci.2019.12.911. PubMed PMID:31953105 PubMed Central PMC7282965.

Tasena, H, Boudewijn, IM, Faiz, A, Timens, W, Hylkema, MN, Berg, M et al.. MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease. Allergy. 2020;75 (3):703-706. doi: 10.1111/all.14060. PubMed PMID:31545509 .

Vieira Braga, FA, Kar, G, Berg, M, Carpaij, OA, Polanski, K, Simon, LM et al.. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat Med. 2019;25 (7):1153-1163. doi: 10.1038/s41591-019-0468-5. PubMed PMID:31209336 .

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