Marnix Jonker

Research Technician

Marnix

Resume

 

Ing.,  Hanze University of Applied Sciences (2001)

Research

As a PI technician, Marnix works on different projects and research lines from all 3 Principal Investigators in the EXPIRE group. He worked on different Lung Fund projects in the past, as well as on projects funded by industry (Astra Zeneca, Roche). Currently he is working on Mitochondrial dysfunction in COPD, Optical Coherence Tomography (OCT) in an in-vitro model on lung tissue’s. Also managing the lab is one of his tasks.

Keywords: Asthma, COPD, IPF, Lung Cells Culture, 3D structured cell culture, mitochondria, lab management 

Kruk, DMLW, Wisman, M, Noordhoek, JA, Nizamoglu, M, Jonker, MR, de Bruin, HG et al.. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells. Cells. 2021;10 (11):. doi: 10.3390/cells10112860. PubMed PMID:34831082 .

Vasse, GF, Van Os, L, De Jager, M, Jonker, MR, Borghuis, T, Van Den Toorn, LT et al.. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices. Front Pharmacol. 2021;12 :669037. doi: 10.3389/fphar.2021.669037. PubMed PMID:34393771 PubMed Central PMC8355988.

Weckmann, M, Bahmer, T, Bülow Sand, JM, Rank Rønnow, S, Pech, M, Vermeulen, C et al.. COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J. 2021; :. doi: 10.1183/13993003.03969-2020. PubMed PMID:34326188 .

Marsh, EK, Prestwich, EC, Williams, L, Hart, AR, Muir, CF, Parker, LC et al.. Pellino-1 Regulates the Responses of the Airway to Viral Infection. Front Cell Infect Microbiol. 2020;10 :456. doi: 10.3389/fcimb.2020.00456. PubMed PMID:32984077 PubMed Central PMC7488214.

Burgess, JK, Jonker, MR, Berg, M, Ten Hacken, NTH, Meyer, KB, van den Berge, M et al.. Periostin: contributor to abnormal airway epithelial function in asthma?. Eur Respir J. 2021;57 (2):. doi: 10.1183/13993003.01286-2020. PubMed PMID:32907887 .

de Hilster, RHJ, Sharma, PK, Jonker, MR, White, ES, Gercama, EA, Roobeek, M et al.. Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue. Am J Physiol Lung Cell Mol Physiol. 2020;318 (4):L698-L704. doi: 10.1152/ajplung.00451.2019. PubMed PMID:32048864 PubMed Central PMC7191637.

Kuchibhotla, VNS, Jonker, MR, de Bruin, HG, Noordhoek, JA, Knight, DA, Nawijn, MC et al.. Inhibition of β-catenin/CBP signalling improves airway epithelial barrier function and suppresses CCL20 release. Allergy. 2020;75 (7):1786-1789. doi: 10.1111/all.14216. PubMed PMID:32027380 PubMed Central PMC7383853.

Hoffmann, RF, Jonker, MR, Brandenburg, SM, de Bruin, HG, Ten Hacken, NHT, van Oosterhout, AJM et al.. Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium. Sci Rep. 2019;9 (1):15047. doi: 10.1038/s41598-019-51517-x. PubMed PMID:31636329 PubMed Central PMC6803636.

Vieira Braga, FA, Kar, G, Berg, M, Carpaij, OA, Polanski, K, Simon, LM et al.. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat Med. 2019;25 (7):1153-1163. doi: 10.1038/s41591-019-0468-5. PubMed PMID:31209336 .

Faiz, A, Steiling, K, Roffel, MP, Postma, DS, Spira, A, Lenburg, ME et al.. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019;53 (4):. doi: 10.1183/13993003.01202-2018. PubMed PMID:30846474 .

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