Mehmet Nizamoglu

Mehmet Nizamoglu

PhD Candidate

Envelope Link Orcid Twitter Linkedin

Resume


PhD Candidate, 2+2 Industry Collaboration Project with Boehringer Ingelheim (Germany) , University of Groningen, The Netherlands, 2019 –

MSc, Medical and Pharmaceutical Drug Innovation (MPDI), cum laude, University of Groningen, The Netherlands, 2019

MSc, Medical Research, Uppsala University, Sweden, 2019

BSc, Molecular Biology and Genetics, Middle East Technical University (METU), Turkey, 2016

Research

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease, which is mainly characterized by remodeling of the alveoli and excessive deposition of extracellular matrix (ECM). Changes in the ECM organization, structure, and composition are both causing factors and results of the progression of the disease. While the cells eventually modify the ECM, the modified ECM could further instruct the cells. The stroma, formed by the ECM and cells, is the microenvironment altered during the fibrotic response and this altered stroma delivers biochemical and biophysical cues to the lung-resident and infiltrating cells – such as macrophages. Therefore, understanding the macrophage-stroma interactions in IPF would be beneficial to analyze how macrophages are involved in IPF and how the macrophage-stroma interactions influence the fibrotic response.
In this project, using novel 3D ECM models, the fibrotic stroma will be mimicked in vitro and interactions between stroma and macrophages will be investigated using this model.

Keywords: macrophages, stroma, fibrosis, stiffness, ECM

Vasse, GF & Nizamoglu, M (2021) J. of Pathology

Click on image to enlarge

Nizamoglu, M, Alleblas, F, Koster, T, Borghuis, T, Vonk, JM, Thomas, MJ et al.. Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts. Acta Biomater. 2024;177 :118-131. doi: 10.1016/j.actbio.2024.02.008. PubMed PMID:38350556 .

Nizamoglu, M, Koloko Ngassie, ML, Meuleman, RA, Banchero, M, Borghuis, T, Timens, W et al.. Collagen type XIV is proportionally lower in the lung tissue of patients with IPF. Sci Rep. 2023;13 (1):19393. doi: 10.1038/s41598-023-46733-5. PubMed PMID:37938243 PubMed Central PMC10632429.

Wisman, M, Nizamoglu, M, Noordhoek, JA, Timens, W, Burgess, JK, Heijink, IH et al.. Dysregulated cross-talk between alveolar epithelial cells and stromal cells in idiopathic pulmonary fibrosis reduces epithelial regenerative capacity. Front Med (Lausanne). 2023;10 :1182368. doi: 10.3389/fmed.2023.1182368. PubMed PMID:37621459 PubMed Central PMC10446880.

Nizamoglu, M, Joglekar, MM, Almeida, CR, Larsson Callerfelt, AK, Dupin, I, Guenat, OT et al.. Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research. Eur Respir Rev. 2023;32 (169):. doi: 10.1183/16000617.0042-2023. PubMed PMID:37495250 PubMed Central PMC10369168.

Nizamoglu, M, Burgess, JK. Current possibilities and future opportunities provided by three-dimensional lung ECM-derived hydrogels. Front Pharmacol. 2023;14 :1154193. doi: 10.3389/fphar.2023.1154193. PubMed PMID:36969853 PubMed Central PMC10034771.

Blokland, KEC, Nizamoglu, M, Habibie, H, Borghuis, T, Schuliga, M, Melgert, BN et al.. Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts. Front Pharmacol. 2022;13 :989169. doi: 10.3389/fphar.2022.989169. PubMed PMID:36408252 PubMed Central PMC9673045.

Joglekar, MM, Nizamoglu, M, Fan, Y, Nemani, SSP, Weckmann, M, Pouwels, SD et al.. Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases. Front Pharmacol. 2022;13 :995051. doi: 10.3389/fphar.2022.995051. PubMed PMID:36408219 PubMed Central PMC9669433.

Nizamoglu, M, de Hilster, RHJ, Zhao, F, Sharma, PK, Borghuis, T, Harmsen, MC et al.. An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition. Acta Biomater. 2022;147 :50-62. doi: 10.1016/j.actbio.2022.05.031. PubMed PMID:35605955 .

Kruk, DMLW, Wisman, M, Noordhoek, JA, Nizamoglu, M, Jonker, MR, de Bruin, HG et al.. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells. Cells. 2021;10 (11):. doi: 10.3390/cells10112860. PubMed PMID:34831082 PubMed Central PMC8616441.

Vasse, GF, Nizamoglu, M, Heijink, IH, Schlepütz, M, van Rijn, P, Thomas, MJ et al.. Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives. J Pathol. 2021;254 (4):344-357. doi: 10.1002/path.5632. PubMed PMID:33506963 PubMed Central PMC8252758.

Search PubMed

2017               Erasmus Mundus Joint Master’s Degree: International Master’s in Innovative Medicine (IMIM) Scholarship

2016             Novartis International Biotechnology Leadership Camp 2016 Scholarship

2014              The University of Tokyo Summer Internship Program in Kashiwa Scholarship

2013              iGEM 2013 European Jamboree Golden Medal Award