Mehmet Nizamoglu

Resume


PhD Candidate, 2+2 Industry Collaboration Project with Boehringer Ingelheim (Germany) , University of Groningen, The Netherlands, 2019 –

MSc, Medical and Pharmaceutical Drug Innovation (MPDI), cum laude, University of Groningen, The Netherlands, 2019

MSc, Medical Research, Uppsala University, Sweden, 2019

BSc, Molecular Biology and Genetics, Middle East Technical University (METU), Turkey, 2016

Research

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease, which is mainly characterized by remodeling of the alveoli and excessive deposition of extracellular matrix (ECM). Changes in the ECM organization, structure, and composition are both causing factors and results of the progression of the disease. While the cells eventually modify the ECM, the modified ECM could further instruct the cells. The stroma, formed by the ECM and cells, is the microenvironment altered during the fibrotic response and this altered stroma delivers biochemical and biophysical cues to the lung-resident and infiltrating cells – such as macrophages. Therefore, understanding the macrophage-stroma interactions in IPF would be beneficial to analyze how macrophages are involved in IPF and how the macrophage-stroma interactions influence the fibrotic response.
In this project, using novel 3D ECM models, the fibrotic stroma will be mimicked in vitro and interactions between stroma and macrophages will be investigated using this model.

Keywords: macrophages, stroma, fibrosis, stiffness, ECM

Vasse, GF & Nizamoglu, M (2021) J. of Pathology

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Kruk, DMLW, Wisman, M, Noordhoek, JA, Nizamoglu, M, Jonker, MR, de Bruin, HG et al.. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells. Cells. 2021;10 (11):. doi: 10.3390/cells10112860. PubMed PMID:34831082 .

Vasse, GF, Nizamoglu, M, Heijink, IH, Schlepütz, M, van Rijn, P, Thomas, MJ et al.. Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives. J Pathol. 2021;254 (4):344-357. doi: 10.1002/path.5632. PubMed PMID:33506963 PubMed Central PMC8252758.

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2017               Erasmus Mundus Joint Master’s Degree: International Master’s in Innovative Medicine (IMIM) Scholarship

2016             Novartis International Biotechnology Leadership Camp 2016 Scholarship

2014              The University of Tokyo Summer Internship Program in Kashiwa Scholarship

2013              iGEM 2013 European Jamboree Golden Medal Award