PhD Candidate, 2+2 Industry Collaboration Project with Boehringer Ingelheim (Germany) , University of Groningen, The Netherlands, 2019 –
MSc, Medical and Pharmaceutical Drug Innovation (MPDI), cum laude, University of Groningen, The Netherlands, 2019
MSc, Medical Research, Uppsala University, Sweden, 2019
BSc, Molecular Biology and Genetics, Middle East Technical University (METU), Turkey, 2016
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease, which is mainly characterized by remodeling of the alveoli and excessive deposition of extracellular matrix (ECM). Changes in the ECM organization, structure, and composition are both causing factors and results of the progression of the disease. While the cells eventually modify the ECM, the modified ECM could further instruct the cells. The stroma, formed by the ECM and cells, is the microenvironment altered during the fibrotic response and this altered stroma delivers biochemical and biophysical cues to the lung-resident and infiltrating cells – such as macrophages. Therefore, understanding the macrophage-stroma interactions in IPF would be beneficial to analyze how macrophages are involved in IPF and how the macrophage-stroma interactions influence the fibrotic response.
In this project, using novel 3D ECM models, the fibrotic stroma will be mimicked in vitro and interactions between stroma and macrophages will be investigated using this model.
Keywords: macrophages, stroma, fibrosis, stiffness, ECM
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Nizamoglu, M, Burgess, JK. Current possibilities and future opportunities provided by three-dimensional lung ECM-derived hydrogels. Front Pharmacol. 2023;14 :1154193. doi: 10.3389/fphar.2023.1154193. PubMed PMID:36969853 PubMed Central PMC10034771.
Blokland, KEC, Nizamoglu, M, Habibie, H, Borghuis, T, Schuliga, M, Melgert, BN et al.. Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts. Front Pharmacol. 2022;13 :989169. doi: 10.3389/fphar.2022.989169. PubMed PMID:36408252 PubMed Central PMC9673045.
Joglekar, MM, Nizamoglu, M, Fan, Y, Nemani, SSP, Weckmann, M, Pouwels, SD et al.. Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases. Front Pharmacol. 2022;13 :995051. doi: 10.3389/fphar.2022.995051. PubMed PMID:36408219 PubMed Central PMC9669433.
Nizamoglu, M, de Hilster, RHJ, Zhao, F, Sharma, PK, Borghuis, T, Harmsen, MC et al.. An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition. Acta Biomater. 2022;147 :50-62. doi: 10.1016/j.actbio.2022.05.031. PubMed PMID:35605955 .
Kruk, DMLW, Wisman, M, Noordhoek, JA, Nizamoglu, M, Jonker, MR, de Bruin, HG et al.. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells. Cells. 2021;10 (11):. doi: 10.3390/cells10112860. PubMed PMID:34831082 PubMed Central PMC8616441.
Vasse, GF, Nizamoglu, M, Heijink, IH, Schlepütz, M, van Rijn, P, Thomas, MJ et al.. Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives. J Pathol. 2021;254 (4):344-357. doi: 10.1002/path.5632. PubMed PMID:33506963 PubMed Central PMC8252758.Search PubMed
2017 Erasmus Mundus Joint Master’s Degree: International Master’s in Innovative Medicine (IMIM) Scholarship
2016 Novartis International Biotechnology Leadership Camp 2016 Scholarship
2014 The University of Tokyo Summer Internship Program in Kashiwa Scholarship
2013 iGEM 2013 European Jamboree Golden Medal Award