Petra van der Velde

Petra van der Velde

Research Technician

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·         Research Technician, Intensive Care – Adults, University Medical Center Groningen, 2023-current

·         Research Technician, EXperimental Pulmonology & Inflammation Research, University Medical Center Groningen, 2021-2023

·         Laboratory Technician, Department of Medical Microbiology, Certe Medical Diagnostics, 2020-2021

·         Research Technician, Lansdorp group & Foijer group, European Research Institute for the Biology of Aging, 2019

·         MSc, Biomedical Sciences – Molecular Cell Biology, VU University Amsterdam, The Netherlands, 2012

·         BSc, Biomedical Research – Biotechnology, Hanze University Groningen, The Netherlands, 2004

Research

My research investigates the underlying mechanisms of persistent acute respiratory distress syndrome (ARDS) in critically ill patients, in close collaboration with Dr. Janesh Pillay (Critical Care) and Professor Janette Burgess (Pathology and Medical Biology).

Using a translational approach, we employ a combination of advanced techniques, including single-cell RNA sequencing (scRNAseq), flow cytometry, advanced molecular imaging, and PET/CT imaging. Our studies focus on interpreting the intricate interplay between the inflammatory microenvironment (comprising immune cells and cytokines) and tissue remodeling processes (involving the extracellular matrix and fibroblasts). Ultimately, we aim to translate these findings into improved therapeutic strategies and enhanced patient care for critically ill patients suffering from persistent lung failure.

Keywords: ARDS, scRNAseq, ECMO, PET/CT, ECM, Fibroblasts

Jiménez-Gracia, L, Maspero, D, Aguilar-Fernández, S, Craighero, F, Boulougouri, M, Ruiz, M et al.. Publisher Correction: Interpretable inflammation landscape of circulating immune cells. Nat Med. 2026;32 (2):765. doi: 10.1038/s41591-026-04223-x. PubMed PMID:41588205 PubMed Central PMC12920112.

Vlasma, JR, Fan, Y, van der Velde, P, Metz, E, Lansink, AO, Hoffmann, RF et al.. Myeloid Cell Differentiation Within Extracorporeal Membrane Oxygenators in Patients With Acute Respiratory Distress Syndrome. ASAIO J. 2026; :. doi: 10.1097/MAT.0000000000002650. PubMed PMID:41527181 .

Jiménez-Gracia, L, Maspero, D, Aguilar-Fernández, S, Craighero, F, Boulougouri, M, Ruiz, M et al.. Interpretable inflammation landscape of circulating immune cells. Nat Med. 2026;32 (2):633-644. doi: 10.1038/s41591-025-04126-3. PubMed PMID:41526507 PubMed Central PMC12920142.

Jiménez-Gracia, L, Marchese, D, Nieto, JC, Caratù, G, Melón-Ardanaz, E, Gudiño, V et al.. FixNCut: single-cell genomics through reversible tissue fixation and dissociation. Genome Biol. 2024;25 (1):81. doi: 10.1186/s13059-024-03219-5. PubMed PMID:38553769 PubMed Central PMC10979608.

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