Publications 2

Or Publications list 1 ?

Below a list of publications found on Pubmed where members of our group where (co)author on:

Kuks PJM; Karp T; Hartman JE; Kraft M; Siddiqui S; Fabbri LM; Beghé B; Rabe KF; Papi A; Brightling CE; Singh D; Li X; Kocks JWH; Scaffidi-Argentina U; Kerstjens HAM; Heijink IH; Pouwels SD; Slebos DJ; van den Berge M, 2025. Cluster Analysis to Identify Distinct Asthma Phenotypes in the ATLANTIS Cohort.  Allergy.

Trejo-Villegas OA; Pineda-Villegas P; Armas-López L; Mendoza-Milla C; Peralta-Arrieta I; Arrieta O; Heijink IH; Zúñiga J; Ávila-Moreno F, 2025. SMARCB1-driven EGFR-GLI1 epigenetic alterations in lung cancer progression and therapy are differentially modulated by MEOX2 and GLI-1.  Cancer Gene Ther 32(3):327-342

Faiz A; Ter Haar EAMD; Hartman JE; Brandsma CA; Timens W; Burgess JK; Choy DF; Grimbaldeston MA; Vanfleteren LEGW; Slebos DJ; van den Berge M; Pouwels SD, 2025. Genome-Wide Differential Airway Gene Expression Analysis Identifies Genes Associated with COPD Comorbidities.  Lung 203(1):58

Nwozor KO; Hackett TL; Chen Q; Yang CX; Aguilar Lozano SP; Zheng X; Al-Fouadi M; Kole TM; Faiz A; Mahbub RM; Slebos DJ; Klooster K; Timens W; van den Berge M; Brandsma CA; Heijink IH, 2025. Effect of age, COPD severity, and cigarette smoke exposure on bronchial epithelial barrier function.  Am J Physiol Lung Cell Mol Physiol 328(5):L724-L737

Chen Q; Wisman M; Nwozor KO; Sin DD; Joubert P; Nickle DC; Brandsma CA; de Vries M; Heijink IH, 2025. COPD susceptibility gene HHIP regulates repair genes in airway epithelial cells and repair within the epithelial-mesenchymal trophic unit.  Am J Physiol Lung Cell Mol Physiol 328(6):L772-L784

Neiens V; Hansbauer EM; Jaquin TJ; Peper-Gabriel JK; Mahavadi P; Snyder ME; Grill MJ; Wurzenberger C; Konitsiotis A; Estrada-Bernal A; Heinig K; Fysikopoulos A; Schwenck N; Grüner S; Bartoschek D; Mosebach T; Kerstan S; Wrennall J; Richter M; Noda K; Hoetzenecker K; Burgess JK; Tarran R; Wurzenberger C; Wichmann KR; Biehler J; Müller KW; Guenther A; Eickelberg O; Fitzgerald MF; Olwill SA; Matschiner G; Pavlidou M, 2025. Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment.  Nat Commun 16(1):3251

Kwant AN; Es Sayed JS; Aledlbi N; Pryshchepa H; van der Zaag PJ; Burgess JK; Slebos DJ; Pouwels SD; Kamperman M, 2025. Improving Complex Coacervate Tissue Adhesive Performance Using Bridging Polymer Chains.  Biomacromolecules 26(4):2433-2443

Rae B; Vasse GF; Mosayebi J; Berge MVD; Pouwels SD; Heijink IH, 2025. Development of a Widely Accessible, Advanced Large-Scale Microfluidic Airway-on-Chip.  Bioengineering (Basel) 12.

Kuks PJM; Kole TM; Kraft M; Siddiqui S; Fabbri LM; Rabe KF; Papi A; Brightling C; Singh D; van der Molen T; Kocks JWWH; Chung KF; Adcock IM; Bhavsar PK; Kermani NZ; Heijink IH; Pouwels SD; Kerstjens HAM; Slebos DJ; van den Berge M, 2025. Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS.  ERJ Open Res 11.

Heijink IH; Nwozor KO; Hackett TL, 2025. Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair.  Am J Respir Cell Mol Biol 73(5):643-645

Berg M; Krabbendam L; van der Ploeg EK; van Nimwegen M; van der Veer T; Banchero M; Carpaij OA; Hoogenboezem R; van den Berge M; Bindels E; Aerts JGJV; Collin A; Barbry P; Kamphuis LS; Hendriks RW; Nawijn MC; Stadhouders R, 2025. Evidence for altered immune-structural cell crosstalk in cystic fibrosis revealed by single cell transcriptomics.  J Cyst Fibros 24(5):849-860

van Baarle D; Nawijn MC, 2025. Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa.  Nat Immunol 26(2):152-154

Pillay J; Flikweert AW; van Meurs M; Grootenboers MJ; van der Sar-van der Brugge S; van der Voort PHJ; Karsdal MA; Sand JMB; Leeming DJ; Burgess JK; Moser J, 2025. Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids.  Respir Res 26(1):32

Liu G; Hsu AC; Geirnaert S; Cong C; Nair PM; Shen S; Marshall JE; Haw TJ; Fricker M; Philp AM; Hansbro NG; Pavlidis S; Guo Y; Burgess JK; Castellano L; Ieni A; Caramori G; Oliver BGG; Chung KF; Adcock IM; Knight DA; Polverino F; Bracke K; Wark PA; Hansbro PM, 2025. Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease.  Mol Ther 33(3):917-932

El-Husseini ZW; Karp T; Lan A; Gillett TE; Qi C; Khalenkow D; van der Molen T; Brightling C; Papi A; Rabe KF; Siddiqui S; Singh D; Kraft M; Beghé B; Joubert P; Bossé Y; Sin D; Cordero AH; Timens W; Brandsma CA; Hao K; Nickle DC; Vonk JM; Nawijn MC; van den Berge M; Gosens R; Faiz A; Koppelman GH, 2025. Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci.  Am J Respir Cell Mol Biol 72(6):607-614

Kwant AN; Es Sayed JS; Kamperman M; Burgess JK; Slebos DJ; Pouwels SD, 2025. Sticky Science: Using Complex Coacervate Adhesives for Biomedical Applications.  Adv Healthc Mater 14(2):e2402340

Firsova AB; Marco Salas S; Kuemmerle LB; Abalo XM; Sountoulidis A; Larsson L; Mahbubani KT; Theelke J; Andrusivova Z; Alonso Galicia L; Liontos A; Balassa T; Kovacs F; Horvath P; Chen Y; Gote-Schniering J; Stoleriu MG; Behr J; Meyer KB; Timens W; Schiller HB; Luecken MD; Theis FJ; Lundeberg J; Nilsson M; Nawijn MC; Samakovlis C, 2025. Spatial single-cell atlas reveals regional variations in healthy and diseased human lung.  Nat Commun 16(1):9745

Wisman M; Kruk DMLW; Kooistra W; Heijink IH; Woldhuis RR, 2025. Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD.  Am J Physiol Lung Cell Mol Physiol 328(6):L858-L865

Fan Y; Moser J; Jongman RM; Borghuis T; Vonk JM; Timens W; van Meurs M; Pillay J; Burgess JK, 2025. Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome.  Am J Physiol Cell Physiol 328(4):C1279-C1292

Gillett TE; Vassileva SM; Weersink E; Annema J; Lutter R; Nawijn MC; van den Berge M; Bonta PI; Ravi A, 2025. Airway Basal Stem Cell Population Is Enlarged in Bronchial Thermoplasty Treated Airways in Severe Asthma Patients.  Clin Exp Allergy 55(9):880-882

Korshevniuk M; Westra HJ; Oelen R; van der Wijst MGP; Franke L; Bonder MJ, 2025. Optimized summary-statistic-based single-cell eQTL meta-analysis.  Sci Rep 15(1):28407

van Smoorenburg LH; Carpaij OA; Galban CJ; Bell AJ; Weinheimer O; Nawijn MC; Kerstjens HAM; van den Berge M, 2025. Airway wall thickness in asthma remission.  ERJ Open Res 11.

Galant SP; Kuks PJM; Kole TM; Kraft M; Siddiqui S; Fabbri LM; Beghé B; Rabe KF; Papi A; Brightling CE; Singh D; Kocks JWH; Franzini L; Vonk JM; Kerstjens HAM; Heijink IH; Pouwels SD; Slebos DJ; van den Berge M, 2025. Assessment of the role of small airway dysfunction in relation to exacerbation risk in patients with well controlled asthma (ATLANTIS): an observational study.  Lancet Respir Med 13(11):990-1000

Vreeman ECA; Pillay J; Burgess JK, 2025. Post-COVID pulmonary sequelae: Mechanisms and potential targets to reduce persistent fibrosis.  Pharmacol Ther 272:108891

Porsbjerg C; Rupani H; Brannan JD; Ueki S; Nawijn MC; Erjefält JS; Chanez P; Anderson GP; Pavord ID, 2025. Reframing remission in severe asthma: a conceptual framework for distinguishing disease activity versus damage.  Lancet Respir Med 13(11):1026-1040

Zheng X; Nwozor KO; Jonker M; Wisman M; Nawijn MC; Heijink IH, 2025. Loss of E-Cadherin Alters Cigarette Smoke Extract (CSE)-Induced Damage and Repair Responses in Human Airway Epithelial Cells; Implications for Chronic Obstructive Pulmonary Disease (COPD).  Mol Cell Biol 45(11):481-494

Rae B; Bood V; Dijk HJ; Vasse GF; Melgert BN; Nagelkerke A; Burgess JK; Slebos DJ; Heijink IH; Pouwels SD, 2025. Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System.  Compr Physiol 15(5):e70051

Joglekar MM; Sand JMB; Borghuis T; Leeming DJ; Karsdal M; Klont F; Bowler RP; Melgert BN; Burgess JK; Pouwels SD, 2025. The Calprotectin Fragment, CPa9-HNE, Is a Plasma Biomarker of Mild Chronic Obstructive Pulmonary Disease.  Cells 14.

Habibie H; Putri KSS; Boorsma CE; Brass DM; Heukels P; Wijsenbeek M; Kool M; van den Berge M; Borghuis T; Vaughan A; Corte T; Liu G; Brandsma CA; Gan CT; Olinga P; Timens W; Kahn N; Hansbro PM; Kreuter M; Burgess JK; Melgert BN, 2025. Osteoprotegerin Is Elevated in Pulmonary Fibrosis and Associates with Idiopathic Pulmonary Fibrosis Progression: A Pilot Study.  Respiration.

Getova VE; Pascual A; Dijkstra R; Gładysz MZ; Ubels D; Wlodarczyk-Biegun MK; Burgess JK; Siebring J; Harmsen MC, 2025. Multilayered Tissue Assemblies Through Tuneable Biodegradable Polyhydroxyalkanoate Polymer (Mesh)-Reinforced Organ-Derived Extracellular Matrix Hydrogels.  Gels 11.

Roffel MP; Brandsma CA; Faiz A; Jonker MR; Timens W; Joos GF; Brusselle GG; Maes T; Bracke KR; van den Berge M; Heijink IH, 2025. The Role of miR-320d in Regulation of Cigarette Smoke-Induced Pro-Inflammatory Responses in COPD.  Arch Bronconeumol.

El-Merhie N; Staab-Weijnitz CA; Burgess JK; Kwapiszewska G, 2025. Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases.  Eur Respir Rev 34.

Liu Y; Papagianis PC; de Kuijper ZSC; Chitty JG; Thomas B; Borghuis T; Jongman RM; Pillay J; Richards EA; Melgert BN; Burgess JK; Bourke JE, 2025. Generation of a novel lung fibrosis model using precision-cut lung slices from transgenic TGFβ1 mice.  Am J Physiol Cell Physiol 329(2):C611-C623

van der Ploeg EA; Faiz A; Teitsma GJ; Brotons AS; Govorukhina N; Sand JMB; Leeming DJ; Melgert BN; Horvatovich P; Burgess JK; Gan CT, 2025. It takes two: Aberrant repair and low-grade inflammation characterize bronchiolitis obliterans syndrome after lung transplantation in serum proteomic analysis.  JHLT Open 9:100303

Wang L; Ozaki M; Heijink IH; Cuevas-Ocaña S, 2025. ERS Congress 2024: highlights from the Basic and Translational Sciences Assembly.  ERJ Open Res 11.

Gillett TE; Brandsma CA; Faiz A; Timens W; Koppelman GH; Nawijn MC; van den Berge M, 2025. Predicting corticosteroid response in COPD using baseline bronchial biopsy DNA methylation.  ERJ Open Res 11.

Khalenkow D; Brandsma CA; Timens W; Choy DF; Grimbaldeston MA; Rosenberger CM; Slebos DJ; Kerstjens HAM; Faiz A; Koppelman GH; Nawijn MC; van den Berge M; Guryev V, 2024. Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe Chronic Obstructive Pulmonary Disease.  Am J Respir Cell Mol Biol 70(5):414-423

Reddy KD; Bizymi N; Schweikert A; Ananth S; Lim CX; Lodge KM; Joannes A; Ubags N; van der Does AM; Cloonan SM; Mailleux A; Mansouri N; Reynaert NL; Heijink IH; Cuevas-Ocaña S, 2024. ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly.  ERJ Open Res 10.

Fan Y; Moser J; van Meurs M; Kiers D; Sand JMB; Leeming DJ; Pickkers P; Burgess JK; Kox M; Pillay J, 2024. Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study.  Crit Care 28(1):120

Jiménez-Gracia L; Marchese D; Nieto JC; Caratù G; Melón-Ardanaz E; Gudiño V; Roth S; Wise K; Ryan NK; Jensen KB; Hernando-Momblona X; Bernardes JP; Tran F; Sievers LK; Schreiber S; van den Berge M; Kole T; van der Velde PL; Nawijn MC; Rosenstiel P; Batlle E; Butler LM; Parish IA; Plummer J; Gut I; Salas A; Heyn H; Martelotto LG, 2024. FixNCut: single-cell genomics through reversible tissue fixation and dissociation.  Genome Biol 25(1):81

Visser N; Herreman LCM; Vandooren J; Pereira RVS; Opdenakker G; Spelbrink REJ; Wilbrink MH; Bremer E; Gosens R; Nawijn MC; van der Ende-Metselaar HH; Smit JM; Laus MC; Laman JD, 2024. Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage.  J Mol Med (Berl) 102(4):521-536

Gay ACA; Banchero M; Carpaij O; Kole TM; Apperloo L; van Gosliga D; Fajar PA; Koppelman GH; Bont L; Hendriks RW; van den Berge M; Nawijn MC, 2024. Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma.  Thorax 79(9):811-821

Nizamoglu M; Alleblas F; Koster T; Borghuis T; Vonk JM; Thomas MJ; White ES; Watson CK; Timens W; El Kasmi KC; Melgert BN; Heijink IH; Burgess JK, 2024. Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts.  Acta Biomater 177:118-131

Wijsman PC; Goorsenberg AWM; Keijzer N; d'Hooghe JNS; Ten Hacken NHT; Shah PL; Weersink EJM; de Brito JM; de Souza Xavier Costa N; Mauad T; Nawijn MC; Vonk JM; Annema JT; Burgess JK; Bonta PI, 2024. Airway wall extracellular matrix changes induced by bronchial thermoplasty in severe asthma.  J Allergy Clin Immunol 153(2):435-446.e4

Faiz A; Wiersma VR; Salzbrunn JB; Brandsma CA; Timens W; Burgess JK; van den Berge M; Slebos DJ; Guryev V; Pouwels SD, 2024. COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities.  Arch Bronconeumol 60(2):119-121

Burgess JK; Weiss DJ; Westergren-Thorsson G; Wigen J; Dean CH; Mumby S; Bush A; Adcock IM, 2024. Extracellular Matrix as a Driver of Chronic Lung Diseases.  Am J Respir Cell Mol Biol 70(4):239-246

Voskamp AL; de Jong NW; Jochems SP; Ozir-Fazalalikhan A; van Hengel ORJ; van der Vlugt LEPM; Stam KA; van den Berge M; Nawijn MC; Braunstahl GJ; Möller GM; van Wijk RG; Smits HH, 2024. Early expansion of allergen-responsive LAP(+) B regulatory cells in allergic rhinitis but not in allergic asthma subjects during allergen immunotherapy.  Allergy 79(4):1060-1064

Saikumar Jayalatha AK; Jonker MR; Carpaij OA; van den Berge M; Affleck KX; Koppelman GH; Nawijn MC, 2024. Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33.  Am J Physiol Lung Cell Mol Physiol 326(1):L65-L70

Song S; van Dijk F; Vasse GF; Liu Q; Gosselink IF; Weltjens E; Remels AHV; de Jager MH; Bos S; Li C; Stoeger T; Rehberg M; Kutschke D; van Eck GWA; Wu X; Willems SH; Boom DHA; Kooter IM; Spierings D; Wardenaar R; Cole M; Nawijn MC; Salvati A; Gosens R; Melgert BN, 2024. Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation.  Am J Respir Crit Care Med 209(4):427-443

Migulina N; de Hilster RHJ; Bartel S; Vedder RHJ; van den Berge M; Nagelkerke A; Timens W; Harmsen MC; Hylkema MN; Brandsma CA; Burgess JK, 2024. 3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes.  Am J Physiol Cell Physiol 326(1):C177-C193

Meiners S; Reynaert NL; Matthaiou AM; Rajesh R; Ahmed E; Guillamat-Prats R; Heijink IH; Cuevas-Ocaña S, 2024. The importance of translational science within the respiratory field.  Breathe (Sheff) 20(1):230183

Burgess JK; Gosens R, 2024. Mechanotransduction and the extracellular matrix: Key drivers of lung pathologies and drug responsiveness.  Biochem Pharmacol 228:116255

Zhang Y; Sigaeva A; Fan S; Norouzi N; Zheng X; Heijink IH; Slebos DJ; Pouwels SD; Schirhagl R, 2024. Dynamics for High-Sensitivity Detection of Free Radicals in Primary Bronchial Epithelial Cells upon Stimulation with Cigarette Smoke Extract.  Nano Lett 24(31):9650-9657

Zhao F; Zhang M; Nizamoglu M; Kaper HJ; Brouwer LA; Borghuis T; Burgess JK; Harmsen MC; Sharma PK, 2024. Fibroblast alignment and matrix remodeling induced by a stiffness gradient in a skin-derived extracellular matrix hydrogel.  Acta Biomater 182:67-80

Karp T; Faiz A; van Nijnatten J; Kerstjens HAM; Boudewijn I; Kraft M; Vonk JM; Nawijn MC; Heijink IH; Beghé B; Rabe KF; Papi A; Brightling C; Singh D; van der Molen T; Siddiqui S; Christenson S; Guryev V; van den Berge M, 2024. Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study.  Thorax 79(10):905-914

Kortekaas RK; Geillinger-Kästle KE; Fuentes-Mateos R; Schönleber A; van der Koog L; Elferink RAB; Al-Alyan N; Burgess JK; Gosens R, 2024. The soluble factor milieu in idiopathic pulmonary fibrosis dysregulates epithelial differentiation.  FASEB J 38(19):e70077

Pouwels SD; Ter Haar EAMD; Heijink IH; Hylkema MN; Koster TD; Kuks PJM; Maassen S; Slebos DJ; Vasse GF; de Vries M; Woldhuis RR; Brandsma CA, 2024. Highlights from the 11th Bronchitis International Symposium: "Heterogeneity of Lung Disease in a Changing Environment," Groningen, The Netherlands, 2024.  Respiration 103(12):765-776

Koloko Ngassie ML; Drake LY; Roos BB; Koenig-Kappes A; Pabelick CM; Gosens R; Brandsma CA; Burgess JK; Prakash YS, 2024. Endoplasmic reticulum stress-induced senescence in human lung fibroblasts.  Am J Physiol Lung Cell Mol Physiol 327(1):L126-L139

Portelli MA; Ketelaar ME; Bates S; Csomor E; Shaw D; Emsley J; Brightling C; Hall I; Affleck K; Edwards M; Nawijn MC; Koppelman GH; Van Oosterhout AJ; Sayers I, 2024. Epithelial Interleukin-1 Receptor-Like-1 Activation Is Contingent on Interleukin-33 Isoforms and Asthma-Related Receptor Variation.  Clin Exp Allergy 54(12):984-995

Vlasma JR; van der Veen TA; de Jager MH; Nawijn MC; Brandsma CA; Melgert BN, 2024. Cigarette smoking prolongs inflammation associated with influenza infection and delays its clearance in mice.  Am J Physiol Lung Cell Mol Physiol 327(5):L634-L645

Getova VE; Pinheiro-Machado E; Harmsen MC; Burgess JK; Smink AM, 2024. The role of extracellular matrix hydrogels and adipose-derived stromal cells in soft tissue vascularization - A systematic review.  Biomater Adv 164:213986

de Hilster RHJ; Reinders-Luinge MA; Schuil A; Borghuis T; Harmsen MC; Burgess JK; Hylkema MN, 2024. A 3D Epithelial-Mesenchymal Co-Culture Model of the Airway Wall Using Native Lung Extracellular Matrix.  Bioengineering (Basel) 11.

Joglekar MM; Bekker NJ; Koloko Ngassie ML; Vonk JM; Borghuis T; Reinders-Luinge M; Bakker J; Woldhuis RR; Pouwels SD; Melgert BN; Timens W; Brandsma CA; Burgess JK, 2024. The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease.  Am J Physiol Lung Cell Mol Physiol 327(3):L304-L318

Zhang M; Zhao F; Zhu Y; Brouwer LA; Van der Veen H; Burgess JK; Harmsen MC, 2024. Physical Properties and Biochemical Composition of Extracellular Matrix-Derived Hydrogels Dictate Vascularization Potential in an Organ-Dependent Fashion.  ACS Appl Mater Interfaces 16(23):29930-29945

Kortekaas RK; Geillinger-Kästle KE; Fuentes-Mateos R; van Orsoy R; Al-Alyan N; Burgess JK; Gosens R, 2024. The disruptive effects of COPD exacerbation-associated factors on epithelial repair responses.  Front Immunol 15:1346491

Xu S; Jiemy WF; Brouwer E; Burgess JK; Heeringa P; van der Geest KSM; Alba-Rovira R; Corbera-Bellalta M; Boots AH; Cid MC; Sandovici M, 2024. Current evidence on the role of fibroblasts in large-vessel vasculitides: From pathogenesis to therapeutics.  Autoimmun Rev 23(6):103574

Hynds RE; Magin CM; Ikonomou L; Aschner Y; Beers MF; Burgess JK; Heise RL; Hume PS; Krasnodembskaya AD; Mei SHJ; Misharin AV; Park JA; Reynolds SD; Tschumperlin DJ; Tanneberger AE; Vaidyanathan S; Waters CM; Zettler PJ; Weiss DJ; Ryan AL, 2024. Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023.  Am J Physiol Lung Cell Mol Physiol 327(3):L327-L340

Saikumar Jayalatha AK; Ketelaar ME; Hesse L; Badi YE; Zounemat-Kermani N; Brouwer S; Dijk NF; van den Berge M; Guryev V; Sayers I; Vonk JE; Adcock IM; Koppelman GH; Nawijn MC, 2024. IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status.  Eur Respir J 63.

Kole TM; Muiser S; Kraft M; Siddiqui S; Fabbri LM; Rabe KF; Papi A; Brightling C; Singh D; van der Molen T; Nawijn MC; Kerstjens HAM; van den Berge M, 2024. Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study.  BMJ Open Respir Res 11.

Trejo-Villegas OA; Heijink IH; Ávila-Moreno F, 2024. Preclinical evidence in the assembly of mammalian SWI/SNF complexes: Epigenetic insights and clinical perspectives in human lung disease therapy.  Mol Ther 32(8):2470-2488

Nizamoglu M; Burgess JK, 2023. Current possibilities and future opportunities provided by three-dimensional lung ECM-derived hydrogels.  Front Pharmacol 14:1154193

Kapellos TS; Baßler K; Fujii W; Nalkurthi C; Schaar AC; Bonaguro L; Pecht T; Galvao I; Agrawal S; Saglam A; Dudkin E; Frishberg A; de Domenico E; Horne A; Donovan C; Kim RY; Gallego-Ortega D; Gillett TE; Ansari M; Schulte-Schrepping J; Offermann N; Antignano I; Sivri B; Lu W; Eapen MS; van Uelft M; Osei-Sarpong C; van den Berge M; Donker HC; Groen HJM; Sohal SS; Klein J; Schreiber T; Feißt A; Yildirim AÖ; Schiller HB; Nawijn MC; Becker M; Händler K; Beyer M; Capasso M; Ulas T; Hasenauer J; Pizarro C; Theis FJ; Hansbro PM; Skowasch D; Schultze JL, 2023. Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.  Cell Rep 42(6):112525

Kortekaas RK; Geillinger-Kästle KE; Borghuis T; Belharch K; Webster M; Timens W; Burgess JK; Gosens R, 2023. Interleukin-11 disrupts alveolar epithelial progenitor function.  ERJ Open Res 9.

Gay ACA; Nawijn MC, 2023. See no allergen, hear no allergen, speak no allergen!  Sci Immunol 8(83):eadh0597

Cuevas Ocaña S; El-Merhie N; Kuipers ME; Lehmann M; Enes SR; Voss C; Dean LSN; Loxham M; Boots AW; Cloonan SM; Greene CM; Heijink IH; Joannes A; Mailleux AA; Mansouri N; Reynaert NL; van der Does AM; Wagner DE; Ubags N, 2023. ERS International Congress 2022: highlights from the Basic and Translational Science Assembly.  ERJ Open Res 9.

Koloko Ngassie ML; De Vries M; Borghuis T; Timens W; Sin DD; Nickle D; Joubert P; Horvatovich P; Marko-Varga G; Teske JJ; Vonk JM; Gosens R; Prakash YS; Burgess JK; Brandsma CA, 2023. Age-associated differences in the human lung extracellular matrix.  Am J Physiol Lung Cell Mol Physiol 324(6):L799-L814

Rathnayake SNH; Ditz B; Willemse BWM; Timens W; Kooistra W; Heijink IH; Oliver BGG; van den Berge M; Faiz A, 2023. Longitudinal Effects of 1-Year Smoking Cessation on Human Bronchial Epithelial Transcriptome.  Chest 164(1):85-89

Muiser S; Imkamp K; Seigers D; Halbersma NJ; Vonk JM; Luijk BHD; Braunstahl GJ; van den Berg JW; Kroesen BJ; Kocks JWH; Heijink IH; Reddel HK; Kerstjens HAM; van den Berge M, 2023. Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD.  Thorax 78(5):451-458

Al-Adwi Y; Westra J; van Goor H; Burgess JK; Denton CP; Mulder DJ, 2023. Macrophages as determinants and regulators of fibrosis in systemic sclerosis.  Rheumatology (Oxford) 62(2):535-545

Kruk D; Yeung ACY; Faiz A; Ten Hacken NHT; Timens W; van Kuppevelt TH; Daamen W; Hof D; Harmsen MC; Rojas M; Heijink IH, 2023. Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls.  Respir Res 24(1):22

Ciminieri C; Woest ME; Reynaert NL; Heijink IH; Wardenaar R; Spierings DCJ; Brandsma CA; Königshoff M; Gosens R, 2023. IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors' Function.  Am J Respir Cell Mol Biol 68(4):444-455

Sikkema L; Ramírez-Suástegui C; Strobl DC; Gillett TE; Zappia L; Madissoon E; Markov NS; Zaragosi LE; Ji Y; Ansari M; Arguel MJ; Apperloo L; Banchero M; Bécavin C; Berg M; Chichelnitskiy E; Chung MI; Collin A; Gay ACA; Gote-Schniering J; Hooshiar Kashani B; Inecik K; Jain M; Kapellos TS; Kole TM; Leroy S; Mayr CH; Oliver AJ; von Papen M; Peter L; Taylor CJ; Walzthoeni T; Xu C; Bui LT; De Donno C; Dony L; Faiz A; Guo M; Gutierrez AJ; Heumos L; Huang N; Ibarra IL; Jackson ND; Kadur Lakshminarasimha Murthy P; Lotfollahi M; Tabib T; Talavera-López C; Travaglini KJ; Wilbrey-Clark A; Worlock KB; Yoshida M; van den Berge M; Bossé Y; Desai TJ; Eickelberg O; Kaminski N; Krasnow MA; Lafyatis R; Nikolic MZ; Powell JE; Rajagopal J; Rojas M; Rozenblatt-Rosen O; Seibold MA; Sheppard D; Shepherd DP; Sin DD; Timens W; Tsankov AM; Whitsett J; Xu Y; Banovich NE; Barbry P; Duong TE; Falk CS; Meyer KB; Kropski JA; Pe'er D; Schiller HB; Tata PR; Schultze JL; Teichmann SA; Misharin AV; Nawijn MC; Luecken MD; Theis FJ, 2023. An integrated cell atlas of the lung in health and disease.  Nat Med 29(6):1563-1577

Faiz A; Pavlidis S; Kuo CH; Rowe A; Hiemstra PS; Timens W; Berg M; Wisman M; Guo YK; Djukanović R; Sterk P; Meyer KB; Nawijn MC; Adcock I; Chung KF; van den Berge M, 2023. Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD.  Thorax 78(4):335-343

Kole TM; Vanden Berghe E; Kraft M; Vonk JM; Nawijn MC; Siddiqui S; Sun K; Fabbri LM; Rabe KF; Chung KF; Nicolini G; Papi A; Brightling C; Singh D; van der Molen T; Dahlén SE; Agusti A; Faner R; Wedzicha JA; Donaldson GC; Adcock IM; Lahousse L; Kerstjens HAM; van den Berge M, 2023. Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study.  Lancet Respir Med 11(1):55-64

Kapellos TS; Nawijn MC, 2023. Editorial: Molecular mechanisms regulating phenotypic heterogeneity in human inflammatory diseases.  Front Immunol 14:1214255

Kole TM; Pouwels SD; Bults R; Ketelaar ME; Guryev V; Koll L; Kerstjens HAM; Nawijn MC; Faiz A; van den Berge M, 2023. Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms.  ERJ Open Res 9.

Pinheiro-Machado E; Getova VE; Harmsen MC; Burgess JK; Smink AM, 2023. Towards standardization of human adipose-derived stromal cells secretomes.  Stem Cell Rev Rep 19(7):2131-2140

Melén E; Lambrecht BN; Lloyd CM; Rothenberg ME; Kabashima K; Luciani F; Coquet JM; Ober C; Nawijn MC; Platts-Mills T; von Mutius E, 2023. A conversation on allergy: recognizing the past and looking to the future.  Immunol Cell Biol 101(10):936-946

Berg M; Petoukhov I; van den Ende I; Meyer KB; Guryev V; Vonk JM; Carpaij O; Banchero M; Hendriks RW; van den Berge M; Nawijn MC, 2023. FastCAR: fast correction for ambient RNA to facilitate differential gene expression analysis in single-cell RNA-sequencing datasets.  BMC Genomics 24(1):722

Zhang M; Zhao F; Zhang X; Brouwer LA; Burgess JK; Harmsen MC, 2023. Fibroblasts alter the physical properties of dermal ECM-derived hydrogels to create a pro-angiogenic microenvironment.  Mater Today Bio 23:100842

El-Husseini ZW; Khalenkow D; Lan A; van der Molen T; Brightling C; Papi A; Rabe KF; Siddiqui S; Singh D; Kraft M; Beghe B; van den Berge M; van Gosliga D; Nawijn MC; Rose-John S; Koppelman GH; Gosens R, 2023. An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma.  Respir Res 24(1):308

Nizamoglu M; Koloko Ngassie ML; Meuleman RA; Banchero M; Borghuis T; Timens W; Nawijn MC; Melgert BN; Heijink IH; Brandsma CA; Burgess JK, 2023. Collagen type XIV is proportionally lower in the lung tissue of patients with IPF.  Sci Rep 13(1):19393

Hiemstra PS; Heijink IH, 2023. Oxidation alters IL-33 function: new insights in the biology of different forms of IL-33 and their relevance for COPD.  Eur Respir J 62.

Faiz A; Mahbub RM; Boedijono FS; Tomassen MI; Kooistra W; Timens W; Nawijn M; Hansbro PM; Johansen MD; Pouwels SD; Heijink IH; Massip F; de Biase MS; Schwarz RF; Adcock IM; Chung KF; van der Does A; Hiemstra PS; Goulaouic H; Xing H; Abdulai R; de Rinaldis E; Cunoosamy D; Harel S; Lederer D; Nivens MC; Wark PA; Kerstjens HAM; Hylkema MN; Brandsma CA; van den Berge M, 2023. IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels.  Am J Respir Crit Care Med 208(10):1075-1087

Van Buren E; Radicioni G; Lester S; O'Neal WK; Dang H; Kasela S; Garudadri S; Curtis JL; Han MK; Krishnan JA; Wan ES; Silverman EK; Hastie A; Ortega VE; Lappalainen T; Nawijn MC; Berge MVD; Christenson SA; Li Y; Cho MH; Kesimer M; Kelada SNP, 2023. Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.  PLoS Genet 19(6):e1010445

Wisman M; Nizamoglu M; Noordhoek JA; Timens W; Burgess JK; Heijink IH, 2023. Dysregulated cross-talk between alveolar epithelial cells and stromal cells in idiopathic pulmonary fibrosis reduces epithelial regenerative capacity.  Front Med (Lausanne) 10:1182368

Chen Q; Vasse GF; Nwozor KO; Bekker NJ; van den Berge M; Brandsma CA; de Vries M; Heijink IH, 2023. FAM13A regulates cellular senescence marker p21 and mitochondrial reactive oxygen species production in airway epithelial cells.  Am J Physiol Lung Cell Mol Physiol 325(4):L460-L466

Pouwels SD; Sigaeva A; de Boer S; Eichhorn IA; Koll L; Kuipers J; Schirhagl R; Heijink IH; Burgess JK; Slebos DJ, 2023. Host-device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling.  J Mater Sci Mater Med 34(7):38

Nizamoglu M; Joglekar MM; Almeida CR; Larsson Callerfelt AK; Dupin I; Guenat OT; Henrot P; van Os L; Otero J; Elowsson L; Farre R; Burgess JK, 2023. Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research.  Eur Respir Rev 32.

Baalbaki N; Blankestijn JM; Abdel-Aziz MI; de Backer J; Bazdar S; Beekers I; Beijers RJHCG; van den Bergh JP; Bloemsma LD; Bogaard HJ; van Bragt JJMH; van den Brink V; Charbonnier JP; Cornelissen MEB; Dagelet Y; Davies EH; van der Does AM; Downward GS; van Drunen CM; Gach D; Geelhoed JJM; Glastra J; Golebski K; Heijink IH; Holtjer JCS; Holverda S; Houweling L; Jacobs JJL; Jonker R; Kos R; Langen RCJ; van der Lee I; Leliveld A; Mohamed Hoesein FAA; Neerincx AH; Noij L; Olsson J; van de Pol M; Pouwels SD; Rolink E; Rutgers M; Șahin H; Schaminee D; Schols AMWJ; Schuurman L; Slingers G; Smeenk O; Sondermeijer B; Skipp PJ; Tamarit M; Verkouter I; Vermeulen R; de Vries R; Weersink EJM; van de Werken M; de Wit-van Wijck Y; Young S; Nossent EJ; Maitland-van der Zee AH, 2023. Precision Medicine for More Oxygen (P4O2)-Study Design and First Results of the Long COVID-19 Extension.  J Pers Med 13.

Gupta A; Burgess JK; Slebos DJ; Pouwels SD, 2023. The development, validation, and in vivo testing of a high-precision bronchial epithelial lining fluid sampling device.  Front Med (Lausanne) 10:1172622

van Breugel M; Fehrmann RSN; Bügel M; Rezwan FI; Holloway JW; Nawijn MC; Fontanella S; Custovic A; Koppelman GH, 2023. Current state and prospects of artificial intelligence in allergy.  Allergy 78(10):2623-2643

Ting AE; Baker EK; Champagne J; Desai TJ; Dos Santos CC; Heijink IH; Itescu S; Le Blanc K; Matthay MA; McAuley DF; McIntyre L; Mei SHJ; Parekkadan B; Rocco PRM; Sheridan J; Thébaud B; Weiss DJ, 2022. Proceedings of the ISCT scientific signature series symposium, "Advances in cell and gene therapies for lung diseases and critical illnesses": International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021.  Cytotherapy 24(8):774-788

Dinesh Kumar N; Ter Ellen BM; Bouma EM; Troost B; van de Pol DPI; van der Ende-Metselaar HH; van Gosliga D; Apperloo L; Carpaij OA; van den Berge M; Nawijn MC; Stienstra Y; Rodenhuis-Zybert IA; Smit JM, 2022. Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells.  Antimicrob Agents Chemother 66(1):e0154321

Aliee H; Massip F; Qi C; Stella de Biase M; van Nijnatten J; Kersten ETG; Kermani NZ; Khuder B; Vonk JM; Vermeulen RCH; Neighbors M; Tew GW; Grimbaldeston MA; Ten Hacken NHT; Hu S; Guo Y; Zhang X; Sun K; Hiemstra PS; Ponder BA; Mäkelä MJ; Malmström K; Rintoul RC; Reyfman PA; Theis FJ; Brandsma CA; Adcock IM; Timens W; Xu CJ; van den Berge M; Schwarz RF; Koppelman GH; Nawijn MC; Faiz A, 2022. Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways.  Allergy 77(2):690-694

Moreno P; Fexova S; George N; Manning JR; Miao Z; Mohammed S; Muñoz-Pomer A; Fullgrabe A; Bi Y; Bush N; Iqbal H; Kumbham U; Solovyev A; Zhao L; Prakash A; García-Seisdedos D; Kundu DJ; Wang S; Walzer M; Clarke L; Osumi-Sutherland D; Tello-Ruiz MK; Kumari S; Ware D; Eliasova J; Arends MJ; Nawijn MC; Meyer K; Burdett T; Marioni J; Teichmann S; Vizcaíno JA; Brazma A; Papatheodorou I, 2022. Expression Atlas update: gene and protein expression in multiple species.  Nucleic Acids Res 50(D1):D129-D140

Gupta A; Burgess JK; Borghuis T; de Vries MP; Kuipers J; Permentier HP; Bischoff R; Slebos DJ; Pouwels SD, 2022. Identification of damage associated molecular patterns and extracellular matrix proteins as major constituents of the surface proteome of lung implantable silicone/nitinol devices.  Acta Biomater 141:209-218

Hesse L; Oude Elberink JNG; van Oosterhout AJM; Nawijn MC, 2022. Allergen immunotherapy for allergic airway diseases: Use lessons from the past to design a brighter future.  Pharmacol Ther 237:108115

Luecken MD; Zaragosi LE; Madissoon E; Sikkema L; Firsova AB; De Domenico E; Kümmerle L; Saglam A; Berg M; Gay ACA; Schniering J; Mayr CH; Abalo XM; Larsson L; Sountoulidis A; Teichmann SA; van Eunen K; Koppelman GH; Saeb-Parsy K; Leroy S; Powell P; Sarkans U; Timens W; Lundeberg J; van den Berge M; Nilsson M; Horváth P; Denning J; Papatheodorou I; Schultze JL; Schiller HB; Barbry P; Petoukhov I; Misharin AV; Adcock IM; von Papen M; Theis FJ; Samakovlis C; Meyer KB; Nawijn MC, 2022. The discovAIR project: a roadmap towards the Human Lung Cell Atlas.  Eur Respir J 60.

Tasena H; Timens W; van den Berge M; van Broekhuizen J; Kennedy BK; Hylkema MN; Brandsma CA; Heijink IH, 2022. MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast-Epithelium Crosstalk.  Cells 11.

de Vries M; Nwozor KO; Muizer K; Wisman M; Timens W; van den Berge M; Faiz A; Hackett TL; Heijink IH; Brandsma CA, 2022. The relation between age and airway epithelial barrier function.  Respir Res 23(1):43

Burgess JK; Harmsen MC, 2022. Chronic lung diseases: entangled in extracellular matrix.  Eur Respir Rev 31.

Roffel MP; Boudewijn IM; van Nijnatten JLL; Faiz A; Vermeulen CJ; van Oosterhout AJ; Affleck K; Timens W; Bracke KR; Maes T; Heijink IH; Brandsma CA; van den Berge M, 2022. Identification of asthma-associated microRNAs in bronchial biopsies.  Eur Respir J 59.

Aghapour M; Ubags ND; Bruder D; Hiemstra PS; Sidhaye V; Rezaee F; Heijink IH, 2022. Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD.  Eur Respir Rev 31.

Nizamoglu M; de Hilster RHJ; Zhao F; Sharma PK; Borghuis T; Harmsen MC; Burgess JK, 2022. An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition.  Acta Biomater 147:50-62

Migulina N; Tjin G; Faiz A; Borghuis T; Zhao F; Kaper HJ; Metzlar M; van Dijk E; Sharma PK; Timens W; Gosens R; Brandsma CA; Burgess JK, 2022. Differential roles for lysyl oxidase (like), family members in chronic obstructive pulmonary disease; from gene and protein expression to function.  FASEB J 36(7):e22374

Martinez-Garcia FD; Fischer T; Hayn A; Mierke CT; Burgess JK; Harmsen MC, 2022. A Beginner's Guide to the Characterization of Hydrogel Microarchitecture for Cellular Applications.  Gels 8.

van Breugel M; Qi C; Xu Z; Pedersen CT; Petoukhov I; Vonk JM; Gehring U; Berg M; Bügel M; Carpaij OA; Forno E; Morin A; Eliasen AU; Jiang Y; van den Berge M; Nawijn MC; Li Y; Chen W; Bont LJ; Bønnelykke K; Celedón JC; Koppelman GH; Xu CJ, 2022. Nasal DNA methylation at three CpG sites predicts childhood allergic disease.  Nat Commun 13(1):7415

Blokland KEC; Nizamoglu M; Habibie H; Borghuis T; Schuliga M; Melgert BN; Knight DA; Brandsma CA; Pouwels SD; Burgess JK, 2022. Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts.  Front Pharmacol 13:989169

Qi C; Berg M; Chu X; Timens W; Kole T; van den Berge M; Xu CJ; Koppelman GH; Nawijn MC; Li Y, 2022. Cell-type eQTL deconvolution of bronchial epithelium through integration of single-cell and bulk RNA-seq.  Allergy 77(12):3663-3666

Chen Q; Nwozor KO; van den Berge M; Slebos DJ; Faiz A; Jonker MR; Boezen HM; Heijink IH; de Vries M, 2022. From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke.  Cells 11.

Zhang M; Getova VE; Martinez-Garcia FD; Borghuis T; Burgess JK; Harmsen MC, 2022. From Macro to Micro: Comparison of Imaging Techniques to Detect Vascular Network Formation in Left Ventricle Decellularized Extracellular Matrix Hydrogels.  Gels 8.

Joglekar MM; Nizamoglu M; Fan Y; Nemani SSP; Weckmann M; Pouwels SD; Heijink IH; Melgert BN; Pillay J; Burgess JK, 2022. Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases.  Front Pharmacol 13:995051

Onnes MC; Alheraky A; Nawijn MC; Sluijter TE; Mulder AB; Arends S; Oude Elberink HNG, 2022. Detection of clonal mast cell disease in wasp venom allergic patients with normal tryptase.  Clin Transl Allergy 12(9):e12174

van der Does AM; Mahbub RM; Ninaber DK; Rathnayake SNH; Timens W; van den Berge M; Aliee H; Theis FJ; Nawijn MC; Hiemstra PS; Faiz A, 2022. Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa.  Respir Res 23(1):227

Hulina-Tomašković A; Somborac-Bačura A; Grdić Rajković M; Hlapčić I; Jonker MR; Heijink IH; Rumora L, 2022. Extracellular Hsp70 modulates 16HBE cells' inflammatory responses to cigarette smoke and bacterial components lipopolysaccharide and lipoteichoic acid.  Cell Stress Chaperones 27(5):587-597

Martinez-Garcia FD; van Dongen JA; Burgess JK; Harmsen MC, 2022. Matrix Metalloproteases from Adipose Tissue-Derived Stromal Cells Are Spatiotemporally Regulated by Hydrogel Mechanics in a 3D Microenvironment.  Bioengineering (Basel) 9.

Wildung M; Herr C; Riedel D; Wiedwald C; Moiseenko A; Ramírez F; Tasena H; Heimerl M; Alevra M; Movsisyan N; Schuldt M; Volceanov-Hahn L; Provoost S; Nöthe-Menchen T; Urrego D; Freytag B; Wallmeier J; Beisswenger C; Bals R; van den Berge M; Timens W; Hiemstra PS; Brandsma CA; Maes T; Andreas S; Heijink IH; Pardo LA; Lizé M, 2022. miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly.  Int J Mol Sci 23.

Ikonomou L; Magnusson M; Dries R; Herzog EL; Hynds RE; Borok Z; Park JA; Skolasinski S; Burgess JK; Turner L; Mojarad SM; Mahoney JE; Lynch T; Lehmann M; Thannickal VJ; Hook JL; Vaughan AE; Hoffman ET; Weiss DJ; Ryan AL, 2022. Stem cells, cell therapies, and bioengineering in lung biology and disease 2021.  Am J Physiol Lung Cell Mol Physiol 323(3):L341-L354

Dwyer DF; Ordovas-Montanes J; Allon SJ; Buchheit KM; Vukovic M; Derakhshan T; Feng C; Lai J; Hughes TK; Nyquist SK; Giannetti MP; Berger B; Bhattacharyya N; Roditi RE; Katz HR; Nawijn MC; Berg M; van den Berge M; Laidlaw TM; Shalek AK; Barrett NA; Boyce JA, 2021. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation.  Sci Immunol 6.

van de Wetering C; Elko E; Berg M; Schiffers CHJ; Stylianidis V; van den Berge M; Nawijn MC; Wouters EFM; Janssen-Heininger YMW; Reynaert NL, 2021. Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?  Redox Biol 43:101995

Koloko Ngassie ML; Brandsma CA; Gosens R; Prakash YS; Burgess JK, 2021. The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête.  Physiology (Bethesda) 36(3):150-159

Saikumar Jayalatha AK; Hesse L; Ketelaar ME; Koppelman GH; Nawijn MC, 2021. The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention.  Pharmacol Ther 225:107847

Hu S; Martinez-Garcia FD; Moeun BN; Burgess JK; Harmsen MC; Hoesli C; de Vos P, 2021. An immune regulatory 3D-printed alginate-pectin construct for immunoisolation of insulin producing β-cells.  Mater Sci Eng C Mater Biol Appl 123:112009

Liu G; Philp AM; Corte T; Travis MA; Schilter H; Hansbro NG; Burns CJ; Eapen MS; Sohal SS; Burgess JK; Hansbro PM, 2021. Therapeutic targets in lung tissue remodelling and fibrosis.  Pharmacol Ther 225:107839

Kruk DMLW; Wisman M; Bruin HG; Lodewijk ME; Hof DJ; Borghuis T; Daamen WF; van Kuppevelt TH; Timens W; Burgess JK; Ten Hacken NHT; Heijink IH, 2021. Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema.  Am J Physiol Lung Cell Mol Physiol 320(5):L832-L844

Muus C; Luecken MD; Eraslan G; Sikkema L; Waghray A; Heimberg G; Kobayashi Y; Vaishnav ED; Subramanian A; Smillie C; Jagadeesh KA; Duong ET; Fiskin E; Torlai Triglia E; Ansari M; Cai P; Lin B; Buchanan J; Chen S; Shu J; Haber AL; Chung H; Montoro DT; Adams T; Aliee H; Allon SJ; Andrusivova Z; Angelidis I; Ashenberg O; Bassler K; Bécavin C; Benhar I; Bergenstråhle J; Bergenstråhle L; Bolt L; Braun E; Bui LT; Callori S; Chaffin M; Chichelnitskiy E; Chiou J; Conlon TM; Cuoco MS; Cuomo ASE; Deprez M; Duclos G; Fine D; Fischer DS; Ghazanfar S; Gillich A; Giotti B; Gould J; Guo M; Gutierrez AJ; Habermann AC; Harvey T; He P; Hou X; Hu L; Hu Y; Jaiswal A; Ji L; Jiang P; Kapellos TS; Kuo CS; Larsson L; Leney-Greene MA; Lim K; Litviňuková M; Ludwig LS; Lukassen S; Luo W; Maatz H; Madissoon E; Mamanova L; Manakongtreecheep K; Leroy S; Mayr CH; Mbano IM; McAdams AM; Nabhan AN; Nyquist SK; Penland L; Poirion OB; Poli S; Qi C; Queen R; Reichart D; Rosas I; Schupp JC; Shea CV; Shi X; Sinha R; Sit RV; Slowikowski K; Slyper M; Smith NP; Sountoulidis A; Strunz M; Sullivan TB; Sun D; Talavera-López C; Tan P; Tantivit J; Travaglini KJ; Tucker NR; Vernon KA; Wadsworth MH; Waldman J; Wang X; Xu K; Yan W; Zhao W; Ziegler CGK, 2021. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.  Nat Med 27(3):546-559

Vasse GF; Nizamoglu M; Heijink IH; Schlepütz M; van Rijn P; Thomas MJ; Burgess JK; Melgert BN, 2021. Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives.  J Pathol 254(4):344-357

Ketelaar ME; Portelli MA; Dijk FN; Shrine N; Faiz A; Vermeulen CJ; Xu CJ; Hankinson J; Bhaker S; Henry AP; Billington CK; Shaw DE; Johnson SR; Benest AV; Pang V; Bates DO; Pogson ZEK; Fogarty A; McKeever TM; Singapuri A; Heaney LG; Mansur AH; Chaudhuri R; Thomson NC; Holloway JW; Lockett GA; Howarth PH; Niven R; Simpson A; Tobin MD; Hall IP; Wain LV; Blakey JD; Brightling CE; Obeidat M; Sin DD; Nickle DC; Bossé Y; Vonk JM; van den Berge M; Koppelman GH; Sayers I; Nawijn MC, 2021. Phenotypic and functional translation of IL33 genetics in asthma.  J Allergy Clin Immunol 147(1):144-157

Kortekaas RK; Burgess JK; van Orsoy R; Lamb D; Webster M; Gosens R, 2021. Therapeutic Targeting of IL-11 for Chronic Lung Disease.  Trends Pharmacol Sci 42(5):354-366

Schupp JC; Adams TS; Cosme C Jr; Raredon MSB; Yuan Y; Omote N; Poli S; Chioccioli M; Rose KA; Manning EP; Sauler M; DeIuliis G; Ahangari F; Neumark N; Habermann AC; Gutierrez AJ; Bui LT; Lafyatis R; Pierce RW; Meyer KB; Nawijn MC; Teichmann SA; Banovich NE; Kropski JA; Niklason LE; Pe'er D; Yan X; Homer RJ; Rosas IO; Kaminski N, 2021. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.  Circulation 144(4):286-302

Burgess JK; Jonker MR; Berg M; Ten Hacken NTH; Meyer KB; van den Berge M; Nawijn MC; Heijink IH, 2021. Periostin: contributor to abnormal airway epithelial function in asthma?  Eur Respir J 57.

Heijink IH; Hackett TL; Pouwels SD, 2021. Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium(†).  J Pathol 253(4):351-354

Xu CJ; Gruzieva O; Qi C; Esplugues A; Gehring U; Bergström A; Mason D; Chatzi L; Porta D; Lodrup Carlsen KC; Baïz N; Madore AM; Alenius H; van Rijkom B; Jankipersadsing SA; van der Vlies P; Kull I; van Hage M; Bustamante M; Lertxundi A; Torrent M; Santorelli G; Fantini MP; Hovland V; Pesce G; Fyhrquist N; Laatikainen T; Nawijn MC; Li Y; Wijmenga C; Netea MG; Bousquet J; Anto JM; Laprise C; Haahtela T; Annesi-Maesano I; Carlsen KH; Gori D; Kogevinas M; Wright J; Söderhäll C; Vonk JM; Sunyer J; Melén E; Koppelman GH, 2021. Shared DNA methylation signatures in childhood allergy: The MeDALL study.  J Allergy Clin Immunol 147(3):1031-1040

Ketelaar ME; Westerlaken-van Ginkel CD; Nawijn MC; Ej Dubois A; Koppelman GH, 2021. IL-1RL1a serum levels and IL1RL1 SNPs in the prediction of food allergy.  Clin Exp Allergy 51(4):614-619

Woldhuis RR; Heijink IH; van den Berge M; Timens W; Oliver BGG; de Vries M; Brandsma CA, 2021. COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins.  Thorax 76(5):508-511

Hesse L; Petersen AH; Nawijn MC, 2021. Methods for Experimental Allergen Immunotherapy: Subcutaneous and Sublingual Desensitization in Mouse Models of Allergic Asthma.  Methods Mol Biol 2223:295-335

van der Ploeg EA; Melgert BN; Burgess JK; Gan CT, 2021. The potential of biomarkers of fibrosis in chronic lung allograft dysfunction.  Transplant Rev (Orlando) 35(3):100626

Waters DW; Schuliga M; Pathinayake PS; Wei L; Tan HY; Blokland KEC; Jaffar J; Westall GP; Burgess JK; Prêle CM; Mutsaers SE; Grainge CL; Knight DA, 2021. A Senescence Bystander Effect in Human Lung Fibroblasts.  Biomedicines 9.

Nemani SSP; Vermeulen CJ; Pech M; Faiz A; Oliver BGG; van den Berge M; Burgess JK; Kopp MV; Weckmann M, 2021. COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding.  ERJ Open Res 7.

Schuliga M; Kanwal A; Read J; Blokland KEC; Burgess JK; Prêle CM; Mutsaers SE; Grainge C; Thomson C; James A; Bartlett NW; Knight DA, 2021. A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF.  Am J Physiol Lung Cell Mol Physiol 321(5):L859-L871

Benam KH; Burgess JK; Stewart AG, 2021. Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models.  Front Pharmacol 12:827172

Dekkers BGJ; Saad SI; van Spelde LJ; Burgess JK, 2021. Basement membranes in obstructive pulmonary diseases.  Matrix Biol Plus 12:100092

Faiz A; Harkness LM; Tjin G; Bernal V; Horvatovich P; James A; Elliot JG; Burgess JK; Ashton AW, 2021. Angiogenic regulatory influence of extracellular matrix deposited by resting state asthmatic and non-asthmatic airway smooth muscle cells is similar.  J Cell Mol Med 25(13):6438-6447

Kruk DMLW; Wisman M; Noordhoek JA; Nizamoglu M; Jonker MR; de Bruin HG; Arevalo Gomez K; Ten Hacken NHT; Pouwels SD; Heijink IH, 2021. Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells.  Cells 10.

Pouwels SD; Burgess JK; Verschuuren E; Slebos DJ, 2021. The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus.  Respir Res 22(1):285

Roffel MP; Maes T; Brandsma CA; van den Berge M; Vanaudenaerde BM; Joos GF; Brusselle GG; Heijink IH; Bracke KR, 2021. MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation.  Am J Physiol Lung Cell Mol Physiol 321(6):L1091-L1104

Martinez-Garcia FD; de Hilster RHJ; Sharma PK; Borghuis T; Hylkema MN; Burgess JK; Harmsen MC, 2021. Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels.  Polymers (Basel) 13.

Martinez-Garcia FD; Valk MM; Sharma PK; Burgess JK; Harmsen MC, 2021. Adipose Tissue-Derived Stromal Cells Alter the Mechanical Stability and Viscoelastic Properties of Gelatine Methacryloyl Hydrogels.  Int J Mol Sci 22.

Joglekar MM; Slebos DJ; Leijten J; Burgess JK; Pouwels SD, 2021. Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction.  Eur Respir Rev 30.

Chen Q; Heijink IH; de Vries M, 2021. Connecting GWAS Susceptibility Genes in COPD: Do We Need to Consider TGF-β2?  Am J Respir Cell Mol Biol 65(5):468-470

Blokland KEC; Habibie H; Borghuis T; Teitsma GJ; Schuliga M; Melgert BN; Knight DA; Brandsma CA; Pouwels SD; Burgess JK, 2021. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM.  Cells 10.

Pouwels SD; Hesse L; Wu X; Allam VSRR; van Oldeniel D; Bhiekharie LJ; Phipps S; Oliver BG; Gosens R; Sukkar MB; Heijink IH, 2021. LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE.  Am J Physiol Lung Cell Mol Physiol 321(4):L641-L652

Chen Q; de Vries M; Nwozor KO; Noordhoek JA; Brandsma CA; Boezen HM; Heijink IH, 2021. A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract.  Front Physiol 12:690936

Schiller HB; van Breugel M; Nawijn MC, 2021. SARS-CoV-2-specific hotspots in virus-host interaction networks.  Nat Immunol 22(7):806-808

Weckmann M; Bahmer T; Sand JM; Rank Rønnow S; Pech M; Vermeulen C; Faiz A; Leeming DJ; Karsdal MA; Lunding L; Oliver BGG; Wegmann M; Ulrich-Merzenich G; Juergens UR; Duhn J; Laumonnier Y; Danov O; Sewald K; Zissler U; Jonker M; König I; Hansen G; von Mutius E; Fuchs O; Dittrich AM; Schaub B; Happle C; Rabe KF; van de Berge M; Burgess JK; Kopp MV, 2021. COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy.  Eur Respir J 58.

Ter Ellen BM; Dinesh Kumar N; Bouma EM; Troost B; van de Pol DPI; van der Ende-Metselaar HH; Apperloo L; van Gosliga D; van den Berge M; Nawijn MC; van der Voort PHJ; Moser J; Rodenhuis-Zybert IA; Smit JM, 2021. Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells.  Viruses 13.

Kuchibhotla VNS; Starkey MR; Reid AT; Heijink IH; Nawijn MC; Hansbro PM; Knight DA, 2021. Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice.  Front Physiol 12:690531

Vasse GF; Van Os L; De Jager M; Jonker MR; Borghuis T; Van Den Toorn LT; Jellema P; White ES; Van Rijn P; Harmsen MC; Heijink IH; Melgert BN; Burgess JK, 2021. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices.  Front Pharmacol 12:669037

Kuchibhotla VNS; Jonker MR; de Bruin HG; Noordhoek JA; Knight DA; Nawijn MC; Heijink IH, 2020. Inhibition of β-catenin/CBP signalling improves airway epithelial barrier function and suppresses CCL20 release.  Allergy 75(7):1786-1789

Ubags ND; Baker J; Boots A; Costa R; El-Merhie N; Fabre A; Faiz A; Heijink IH; Hiemstra PS; Lehmann M; Meiners S; Rolandsson Enes S; Bartel S, 2020. ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.  ERJ Open Res 6.

van der Wijst M; de Vries DH; Groot HE; Trynka G; Hon CC; Bonder MJ; Stegle O; Nawijn MC; Idaghdour Y; van der Harst P; Ye CJ; Powell J; Theis FJ; Mahfouz A; Heinig M; Franke L, 2020. The single-cell eQTLGen consortium.  Elife 9.

Ali MK; Kim RY; Brown AC; Donovan C; Vanka KS; Mayall JR; Liu G; Pillar AL; Jones-Freeman B; Xenaki D; Borghuis T; Karim R; Pinkerton JW; Aryal R; Heidari M; Martin KL; Burgess JK; Oliver BG; Trinder D; Johnstone DM; Milward EA; Hansbro PM; Horvat JC, 2020. Critical role for iron accumulation in the pathogenesis of fibrotic lung disease.  J Pathol 251(1):49-62

de Hilster RHJ; Sharma PK; Jonker MR; White ES; Gercama EA; Roobeek M; Timens W; Harmsen MC; Hylkema MN; Burgess JK, 2020. Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue.  Am J Physiol Lung Cell Mol Physiol 318(4):L698-L704

Ge L; Yang L; Bron R; Burgess JK; van Rijn P, 2020. Topography-Mediated Fibroblast Cell Migration Is Influenced by Direction, Wavelength, and Amplitude.  ACS Appl Bio Mater 3(4):2104-2116

Zuo H; Trombetta-Lima M; Heijink IH; van der Veen CHTJ; Hesse L; Faber KN; Poppinga WJ; Maarsingh H; Nikolaev VO; Schmidt AM, 2020. A-Kinase Anchoring Proteins Diminish TGF-β(1)/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.  Cells 9.

Osei ET; Brandsma CA; Timens W; Heijink IH; Hackett TL, 2020. Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD.  Eur Respir J 55.

Qi C; Jiang Y; Yang IV; Forno E; Wang T; Vonk JM; Gehring U; Smit HA; Milanzi EB; Carpaij OA; Berg M; Hesse L; Brouwer S; Cardwell J; Vermeulen CJ; Acosta-Pérez E; Canino G; Boutaoui N; van den Berge M; Teichmann SA; Nawijn MC; Chen W; Celedón JC; Xu CJ; Koppelman GH, 2020. Nasal DNA methylation profiling of asthma and rhinitis.  J Allergy Clin Immunol 145(6):1655-1663

Dijk FN; Vijverberg SJ; Hernandez-Pacheco N; Repnik K; Karimi L; Mitratza M; Farzan N; Nawijn MC; Burchard EG; Engelkes M; Verhamme KM; Potočnik U; Pino-Yanes M; Postma DS; Maitland-van der Zee AH; Koppelman GH, 2020. IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids.  Allergy 75(4):984-989

Boudewijn IM; Lan A; Faiz A; Cox CA; Brouwer S; Schokker S; Vroegop SJ; Nawijn MC; Woodruff PG; Christenson SA; Hagedoorn P; Frijlink HW; Choy DF; Brouwer U; Wisman M; Postma DS; Fingleton J; Beasley R; van den Berge M; Guryev V, 2020. Nasal gene expression changes with inhaled corticosteroid treatment in asthma.  Allergy 75(1):191-194

Vermeulen CJ; Xu CJ; Vonk JM; Ten Hacken NHT; Timens W; Heijink IH; Nawijn MC; Boekhoudt J; van Oosterhout AJ; Affleck K; Weckmann M; Koppelman GH; van den Berge M, 2020. Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission.  Eur Respir J 55.

Aghapour M; Remels AHV; Pouwels SD; Bruder D; Hiemstra PS; Cloonan SM; Heijink IH, 2020. Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease.  Am J Physiol Lung Cell Mol Physiol 318(1):L149-L164

Zuo H; Faiz A; van den Berge M; Mudiyanselage SNHR; Borghuis T; Timens W; Nikolaev VO; Burgess JK; Schmidt M, 2020. Cigarette smoke exposure alters phosphodiesterases in human structural lung cells.  Am J Physiol Lung Cell Mol Physiol 318(1):L59-L64

Tasena H; Boudewijn IM; Faiz A; Timens W; Hylkema MN; Berg M; Ten Hacken NHT; Brandsma CA; Heijink IH; van den Berge M, 2020. MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease.  Allergy 75(3):703-706

Blais-Lecours P; Laouafa S; Arias-Reyes C; Santos WL; Joseph V; Burgess JK; Halayko AJ; Soliz J; Marsolais D, 2020. Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis.  Am J Respir Cell Mol Biol 62(1):35-42

Kuchibhotla VNS; Heijink IH, 2020. Join or Leave the Club: Jagged1 and Notch2 Dictate the Fate of Airway Epithelial Cells.  Am J Respir Cell Mol Biol 63(1):4-6

Aliee H; Massip F; Qi C; de Biase MS; van Nijnatten J; Kersten ETG; Kermani NZ; Khuder B; Vonk JM; Vermeulen RCH; Neighbors M; Tew GW; Grimbaldeston M; Ten Hacken NHT; Hu S; Guo Y; Zhang X; Sun K; Hiemstra PS; Ponder BA; Mäkelä MJ; Malmström K; Rintoul RC; Reyfman PA; Theis FJ; Brandsma CA; Adcock IM; Timens W; Xu CJ; van den Berge M; Schwarz RF; Koppelman GH; Nawijn MC; Faiz A, 2020. Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways.  medRxiv.

Koopmans T; Hesse L; Nawijn MC; Kumawat K; Menzen MH; Sophie T Bos I; Smits R; Bakker ERM; van den Berge M; Koppelman GH; Guryev V; Gosens R, 2020. Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation.  Sci Rep 10(1):6754

Roffel MP; Bracke KR; Heijink IH; Maes T, 2020. miR-223: A Key Regulator in the Innate Immune Response in Asthma and COPD.  Front Med (Lausanne) 7:196

Hesse L; van Ieperen N; Petersen AH; Elberink JNGO; van Oosterhout AJM; Nawijn MC, 2020. High dose vitamin D(3) empowers effects of subcutaneous immunotherapy in a grass pollen-driven mouse model of asthma.  Sci Rep 10(1):20876

Blokland KEC; Pouwels SD; Schuliga M; Knight DA; Burgess JK, 2020. Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases.  Clin Sci (Lond) 134(20):2681-2706

Faiz A; Imkamp K; van der Wiel E; Boudewijn IM; Koppelman GH; Brandsma CA; Kerstjens HAM; Timens W; Vroegop S; Pasma HR; Boersma WG; Wielders P; van den Elshout F; Mansour K; Steiling K; Spira A; Lenburg ME; Heijink IH; Postma DS; van den Berge M, 2020. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD.  Sci Rep 10(1):17415

Marsh EK; Prestwich EC; Williams L; Hart AR; Muir CF; Parker LC; Jonker MR; Heijink IH; Timens W; Fife M; Hussell T; Hershenson MB; Bentley JK; Sun SC; Barksby BS; Borthwick LA; Stewart JP; Sabroe I; Dockrell DH; Marriott HM, 2020. Pellino-1 Regulates the Responses of the Airway to Viral Infection.  Front Cell Infect Microbiol 10:456

Portelli MA; Dijk FN; Ketelaar ME; Shrine N; Hankinson J; Bhaker S; Grotenboer NS; Obeidat M; Henry AP; Billington CK; Shaw D; Johnson SR; Pogson ZE; Fogarty A; McKeever TM; Nickle DC; Bossé Y; van den Berge M; Faiz A; Brouwer S; Vonk JM; de Vos P; Brandsma CA; Vermeulen CJ; Singapuri A; Heaney LG; Mansur AH; Chaudhuri R; Thomson NC; Holloway JW; Lockett GA; Howarth PH; Niven R; Simpson A; Blakey JD; Tobin MD; Postma DS; Hall IP; Wain LV; Nawijn MC; Brightling CE; Koppelman GH; Sayers I, 2020. Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.  JCI Insight 5.

Nawijn MC; Timens W, 2020. Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?  Mol Syst Biol 16(7):e9841

Jiang J; Faiz A; Berg M; Carpaij OA; Vermeulen CJ; Brouwer S; Hesse L; Teichmann SA; Ten Hacken NHT; Timens W; van den Berge M; Nawijn MC, 2020. Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma.  Clin Exp Allergy 50(12):1428-1431

Hesse L; Petersen AH; Oude Elberink JNG; van Oosterhout AJM; Nawijn MC, 2020. 1,25(OH)(2)VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model.  Sci Rep 10(1):8960

Woldhuis RR; de Vries M; Timens W; van den Berge M; Demaria M; Oliver BGG; Heijink IH; Brandsma CA, 2020. Link between increased cellular senescence and extracellular matrix changes in COPD.  Am J Physiol Lung Cell Mol Physiol 319(1):L48-L60

Heijink IH; Kuchibhotla VNS; Roffel MP; Maes T; Knight DA; Sayers I; Nawijn MC, 2020. Epithelial cell dysfunction, a major driver of asthma development.  Allergy 75(8):1902-1917

Osei ET; B Mostaço-Guidolin L; Hsieh A; Warner SM; Al-Fouadi M; Wang M; Cole DJ; Maksym GN; S Hallstrand T; Timens W; Brandsma CA; Heijink IH; Hackett TL, 2020. Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma.  Sci Rep 10(1):8721

Carpaij OA; Goorsenberg AWM; d'Hooghe JNS; de Bruin DM; van den Elzen RM; Nawijn MC; Annema JT; van den Berge M; Bonta PI; Burgess JK, 2020. Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall.  Am J Respir Crit Care Med 202(5):762-766

Blokland KEC; Waters DW; Schuliga M; Read J; Pouwels SD; Grainge CL; Jaffar J; Westall G; Mutsaers SE; Prêle CM; Burgess JK; Knight DA, 2020. Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing.  Pharmaceutics 12.

Boudewijn IM; Roffel MP; Vermeulen CJ; Nawijn MC; Kok K; Terpstra MM; Koppelman GH; Guryev V; van den Berge M, 2020. A Novel Role for Bronchial MicroRNAs and Long Noncoding RNAs in Asthma Remission.  Am J Respir Crit Care Med 202(4):614-618

Sungnak W; Huang N; Bécavin C; Berg M; Queen R; Litvinukova M; Talavera-López C; Maatz H; Reichart D; Sampaziotis F; Worlock KB; Yoshida M; Barnes JL, 2020. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.  Nat Med 26(5):681-687

Burgess JK; Weckmann M; Karsdal MA, 2019. The message from the matrix-should we listen more closely?  J Thorac Dis 11(Suppl 3):S230-S233

Hulina-Tomašković A; Heijink IH; Jonker MR; Somborac-Bačura A; Grdić Rajković M; Rumora L, 2019. Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients.  Biochimie 156:47-58

Waters DW; Blokland KEC; Pathinayake PS; Wei L; Schuliga M; Jaffar J; Westall GP; Hansbro PM; Prele CM; Mutsaers SE; Bartlett NW; Burgess JK; Grainge CL; Knight DA, 2019. STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts.  Am J Respir Cell Mol Biol 61(1):61-73

Faiz A; Steiling K; Roffel MP; Postma DS; Spira A; Lenburg ME; Borggrewe M; Eijgenraam TR; Jonker MR; Koppelman GH; Pouwels SD; Liu G; Alekseyev YO; Lam S; Hiemstra PS; Sterk PJ; Timens W; Brandsma CA; Heijink IH; van den Berge M, 2019. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.  Eur Respir J 53.

Carpaij OA; Vonk JM; Nawijn MC; Kerstjens HAM; Koppelman GH; van den Berge M, 2019. Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies.  J Allergy Clin Immunol 143(5):1973-1975

Taylor DM; Aronow BJ; Tan K; Bernt K; Salomonis N; Greene CS; Frolova A; Henrickson SE; Wells A; Pei L; Jaiswal JK; Whitsett J; Hamilton KE; MacParland SA; Kelsen J; Heuckeroth RO; Potter SS; Vella LA; Terry NA; Ghanem LR; Kennedy BC; Helbig I; Sullivan KE; Castelo-Soccio L; Kreigstein A; Herse F; Nawijn MC; Koppelman GH; Haendel M; Harris NL; Rokita JL; Zhang Y; Regev A; Rozenblatt-Rosen O; Rood JE; Tickle TL; Vento-Tormo R; Alimohamed S; Lek M; Mar JC; Loomes KM; Barrett DM; Uapinyoying P; Beggs AH; Agrawal PB; Chen YW; Muir AB; Garmire LX; Snapper SB; Nazarian J; Seeholzer SH; Fazelinia H; Singh LN; Faryabi RB; Raman P; Dawany N; Xie HM; Devkota B; Diskin SJ; Anderson SA; Rappaport EF; Peranteau W; Wikenheiser-Brokamp KA; Teichmann S; Wallace D; Peng T; Ding YY; Kim MS; Xing Y; Kong SW; Bönnemann CG; Mandl KD; White PS, 2019. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.  Dev Cell 49(1):10-29

Mostaço-Guidolin LB; Osei ET; Ullah J; Hajimohammadi S; Fouadi M; Li X; Li V; Shaheen F; Yang CX; Chu F; Cole DJ; Brandsma CA; Heijink IH; Maksym GN; Walker D; Hackett TL, 2019. Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma.  Am J Respir Crit Care Med 200(4):431-443

Schiller HB; Montoro DT; Simon LM; Rawlins EL; Meyer KB; Strunz M; Vieira Braga FA; Timens W; Koppelman GH; Budinger GRS; Burgess JK; Waghray A; van den Berge M; Theis FJ; Regev A; Kaminski N; Rajagopal J; Teichmann SA; Misharin AV; Nawijn MC, 2019. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease.  Am J Respir Cell Mol Biol 61(1):31-41

Hesse L; Feenstra R; Ambrosini M; de Jager WA; Petersen A; Vietor H; Unger WWJ; van Kooyk Y; Nawijn MC, 2019. Subcutaneous immunotherapy using modified Phl p5a-derived peptides efficiently alleviates allergic asthma in mice.  Allergy 74(12):2495-2498

Murtha LA; Morten M; Schuliga MJ; Mabotuwana NS; Hardy SA; Waters DW; Burgess JK; Ngo DT; Sverdlov AL; Knight DA; Boyle AJ, 2019. The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis.  Aging Dis 10(2):419-428

Nikolić MZ; Garrido-Martin EM; Greiffo FR; Fabre A; Heijink IH; Boots A; Greene CM; Hiemstra PS; Bartel S, 2019. From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science.".  ERJ Open Res 5.

Vieira Braga FA; Kar G; Berg M; Carpaij OA; Polanski K; Simon LM; Brouwer S; Gomes T; Hesse L; Jiang J; Fasouli ES; Efremova M; Vento-Tormo R; Talavera-López C; Jonker MR; Affleck K; Palit S; Strzelecka PM; Firth HV; Mahbubani KT; Cvejic A; Meyer KB; Saeb-Parsy K; Luinge M; Brandsma CA; Timens W; Angelidis I; Strunz M; Koppelman GH; van Oosterhout AJ; Schiller HB; Theis FJ; van den Berge M; Nawijn MC; Teichmann SA, 2019. A cellular census of human lungs identifies novel cell states in health and in asthma.  Nat Med 25(7):1153-1163

Liu G; Cooley MA; Jarnicki AG; Borghuis T; Nair PM; Tjin G; Hsu AC; Haw TJ; Fricker M; Harrison CL; Jones B; Hansbro NG; Wark PA; Horvat JC; Argraves WS; Oliver BG; Knight DA; Burgess JK; Hansbro PM, 2019. Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.  JCI Insight 5.

Schenk HM; van Ockenburg SL; Nawijn MC; De Jonge P; Rosmalen JGM, 2019. Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study.  PLoS One 14(9):e0221993

Hoffmann RF; Jonker MR; Brandenburg SM; de Bruin HG; Ten Hacken NHT; van Oosterhout AJM; Heijink IH, 2019. Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium.  Sci Rep 9(1):15047

Carpaij OA; Muiser S; Bell AJ; Kerstjens HAM; Galban CJ; Fortuna AB; Siddiqui S; Olin AC; Nawijn MC; van den Berge M, 2019. Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air.  ERJ Open Res 5.

Imkamp K; Bernal V; Grzegorzcyk M; Horvatovich P; Vermeulen CJ; Heijink IH; Guryev V; Kerstjens HAM; van den Berge M; Faiz A, 2019. Gene network approach reveals co-expression patterns in nasal and bronchial epithelium.  Sci Rep 9(1):15835

Carpaij OA; Burgess JK; Kerstjens HAM; Nawijn MC; van den Berge M, 2019. A review on the pathophysiology of asthma remission.  Pharmacol Ther 201:8-24

Xu CJ; Söderhäll C; Bustamante M; Baïz N; Gruzieva O; Gehring U; Mason D; Chatzi L; Basterrechea M; Llop S; Torrent M; Forastiere F; Fantini MP; Carlsen KCL; Haahtela T; Morin A; Kerkhof M; Merid SK; van Rijkom B; Jankipersadsing SA; Bonder MJ; Ballereau S; Vermeulen CJ; Aguirre-Gamboa R; de Jongste JC; Smit HA; Kumar A; Pershagen G; Guerra S; Garcia-Aymerich J; Greco D; Reinius L; McEachan RRC; Azad R; Hovland V; Mowinckel P; Alenius H; Fyhrquist N; Lemonnier N; Pellet J; Auffray C; van der Vlies P; van Diemen CC; Li Y; Wijmenga C; Netea MG; Moffatt MF; Cookson WOCM; Anto JM; Bousquet J; Laatikainen T; Laprise C; Carlsen KH; Gori D; Porta D; Iñiguez C; Bilbao JR; Kogevinas M; Wright J; Brunekreef B; Kere J; Nawijn MC; Annesi-Maesano I; Sunyer J; Melén E; Koppelman GH, 2018. DNA methylation in childhood asthma: an epigenome-wide meta-analysis.  Lancet Respir Med 6(5):379-388

Dijk FN; Xu C; Melén E; Carsin AE; Kumar A; Nolte IM; Gruzieva O; Pershagen G; Grotenboer NS; Savenije OEM; Antó JM; Lavi I; Dobaño C; Bousquet J; van der Vlies P; van der Valk RJP; de Jongste JC; Nawijn MC; Guerra S; Postma DS; Koppelman GH, 2018. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma.  Eur Respir J 51.

Jaffar J; Yang SH; Kim SY; Kim HW; Faiz A; Chrzanowski W; Burgess JK, 2018. Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis.  Am J Physiol Lung Cell Mol Physiol 315(1):L59-L65

Wang J; Faiz A; Ge Q; Vermeulen CJ; Van der Velden J; Snibson KJ; van de Velde R; Sawant S; Xenaki D; Oliver B; Timens W; Ten Hacken N; van den Berge M; James A; Elliot JG; Dong L; Burgess JK; Ashton AW, 2018. Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling.  J Cell Mol Med 22(5):2826-2837

Aghapour M; Raee P; Moghaddam SJ; Hiemstra PS; Heijink IH, 2018. Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure.  Am J Respir Cell Mol Biol 58(2):157-169

Di Vincenzo S; Heijink IH; Noordhoek JA; Cipollina C; Siena L; Bruno A; Ferraro M; Postma DS; Gjomarkaj M; Pace E, 2018. SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells.  J Cell Mol Med 22(4):2272-2282

Burgess JK; Ketheson A; Faiz A; Limbert Rempel KA; Oliver BG; Ward JPT; Halayko AJ, 2018. Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors.  Sci Rep 8(1):805

Hesse L; van Ieperen N; Habraken C; Petersen AH; Korn S; Smilda T; Goedewaagen B; Ruiters MH; van der Graaf AC; Nawijn MC, 2018. Subcutaneous immunotherapy with purified Der p1 and 2 suppresses type 2 immunity in a murine asthma model.  Allergy 73(4):862-874

Terlizzi V; Kolibabka M; Burgess JK; Hammes HP; Harmsen MC, 2018. The Pericytic Phenotype of Adipose Tissue-Derived Stromal Cells Is Promoted by NOTCH2.  Stem Cells 36(2):240-251

van den Berge M; Jonker MR; Miller-Larsson A; Postma DS; Heijink IH, 2018. Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells.  Pulm Pharmacol Ther 50:47-56

Imkamp K; Berg M; Vermeulen CJ; Heijink IH; Guryev V; Kerstjens HAM; Koppelman GH; van den Berge M; Faiz A, 2018. Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci.  J Allergy Clin Immunol 142(1):314-317.e15

Nissen G; Hollaender H; Tang FSM; Wegmann M; Lunding L; Vock C; Bachmann A; Lemmel S; Bartels R; Oliver BG; Burgess JK; Becker T; Kopp MV; Weckmann M, 2018. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation.  Clin Exp Allergy 48(11):1483-1493

Waters DW; Blokland KEC; Pathinayake PS; Burgess JK; Mutsaers SE; Prele CM; Schuliga M; Grainge CL; Knight DA, 2018. Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis.  Am J Physiol Lung Cell Mol Physiol 315(2):L162-L172

Tasena H; Faiz A; Timens W; Noordhoek J; Hylkema MN; Gosens R; Hiemstra PS; Spira A; Postma DS; Tew GW; Grimbaldeston MA; van den Berge M; Heijink IH; Brandsma CA, 2018. microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.  Eur Respir J 52.

Ng-Blichfeldt JP; Schrik A; Kortekaas RK; Noordhoek JA; Heijink IH; Hiemstra PS; Stolk J; Königshoff M; Gosens R, 2018. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.  EBioMedicine 36:461-474

Post S; Heijink IH; Hesse L; Koo HK; Shaheen F; Fouadi M; Kuchibhotla VNS; Lambrecht BN; Van Oosterhout AJM; Hackett TL; Nawijn MC, 2018. Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology.  Sci Rep 8(1):13275

Faiz A; Heijink IH; Vermeulen CJ; Guryev V; van den Berge M; Nawijn MC; Pouwels SD, 2018. Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release.  Sci Rep 8(1):12426

Schuliga M; Pechkovsky DV; Read J; Waters DW; Blokland KEC; Reid AT; Hogaboam CM; Khalil N; Burgess JK; Prêle CM; Mutsaers SE; Jaffar J; Westall G; Grainge C; Knight DA, 2018. Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts.  J Cell Mol Med 22(12):5847-5861

Faiz A; Weckmann M; Tasena H; Vermeulen CJ; Van den Berge M; Ten Hacken NHT; Halayko AJ; Ward JPT; Lee TH; Tjin G; Black JL; Haghi M; Xu CJ; King GG; Farah CS; Oliver BG; Heijink IH; Burgess JK, 2018. Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.  Eur Respir J 52.

Billatos E; Faiz A; Gesthalter Y; LeClerc A; Alekseyev YO; Xiao X; Liu G; Ten Hacken NHT; Heijink IH; Timens W; Brandsma CA; Postma DS; van den Berge M; Spira A; Lenburg ME, 2018. Impact of acute exposure to cigarette smoke on airway gene expression.  Physiol Genomics 50(9):705-713

Carpaij OA; Muntinghe FOW; Wagenaar MB; Habing JW; Timens W; Kerstjens HAM; Nawijn MC; Kunz LIZ; Hiemstra PS; Tew GW; Holweg CTJ; Brandsma CA; van den Berge M, 2018. Serum periostin does not reflect type 2-driven inflammation in COPD.  Respir Res 19(1):112

Hesse L; Brouwer U; Petersen AH; Gras R; Bosman L; Brimnes J; Oude Elberink JNG; van Oosterhout AJM; Nawijn MC, 2018. Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma.  Clin Exp Allergy 48(8):1035-1049

Kruk DMLW; Heijink IH; Slebos DJ; Timens W; Ten Hacken NH, 2018. Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon?  Respiration 96(2):148-158

Faiz A; Donovan C; Nieuwenhuis MA; van den Berge M; Postma DS; Yao S; Park CY; Hirsch R; Fredberg JJ; Tjin G; Halayko AJ; Rempel KL; Ward JP; Lee T; Bossé Y; Nickle DC; Obeidat M; Vonk JM; Black JL; Oliver BG; Krishnan R; McParland B; Bourke JE; Burgess JK, 2017. Latrophilin receptors: novel bronchodilator targets in asthma.  Thorax 72(1):74-82

Song J; Heijink IH; Kistemaker LEM; Reinders-Luinge M; Kooistra W; Noordhoek JA; Gosens R; Brandsma CA; Timens W; Hiemstra PS; Rots MG; Hylkema MN, 2017. Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.  Clin Epigenetics 9:42

Pouwels SD; van Geffen WH; Jonker MR; Kerstjens HA; Nawijn MC; Heijink IH, 2017. Increased neutrophil expression of pattern recognition receptors during COPD exacerbations.  Respirology 22(2):401-404

Song J; Cano-Rodriquez D; Winkle M; Gjaltema RA; Goubert D; Jurkowski TP; Heijink IH; Rots MG; Hylkema MN, 2017. Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells.  Am J Physiol Lung Cell Mol Physiol 312(3):L334-L347

Hesse L; Nawijn MC, 2017. Subcutaneous and Sublingual Immunotherapy in a Mouse Model of Allergic Asthma.  Methods Mol Biol 1559:137-168

Anto JM; Bousquet J; Akdis M; Auffray C; Keil T; Momas I; Postma DS; Valenta R; Wickman M; Cambon-Thomsen A; Haahtela T; Lambrecht BN; Lodrup Carlsen KC; Koppelman GH; Sunyer J; Zuberbier T; Annesi-Maesano I; Arno A; Bindslev-Jensen C; De Carlo G; Forastiere F; Heinrich J; Kowalski ML; Maier D; Melén E; Smit HA; Standl M; Wright J; Asarnoj A; Benet M; Ballardini N; Garcia-Aymerich J; Gehring U; Guerra S; Hohmann C; Kull I; Lupinek C; Pinart M; Skrindo I; Westman M; Smagghe D; Akdis C; Andersson N; Bachert C; Ballereau S; Ballester F; Basagana X; Bedbrook A; Bergstrom A; von Berg A; Brunekreef B; Burte E; Carlsen KH; Chatzi L; Coquet JM; Curin M; Demoly P; Eller E; Fantini MP; von Hertzen L; Hovland V; Jacquemin B; Just J; Keller T; Kiss R; Kogevinas M; Koletzko S; Lau S; Lehmann I; Lemonnier N; Mäkelä M; Mestres J; Mowinckel P; Nadif R; Nawijn MC; Pellet J; Pin I; Porta D; Rancière F; Rial-Sebbag E; Saeys Y; Schuijs MJ; Siroux V; Tischer CG; Torrent M; Varraso R; Wenzel K; Xu CJ, 2017. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes.  J Allergy Clin Immunol 139(2):388-399

Ketelaar ME; van de Kant KD; Dijk FN; Klaassen EM; Grotenboer NS; Nawijn MC; Dompeling E; Koppelman GH, 2017. Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO.  Allergy 72(11):1811-1815

Aguilar D; Pinart M; Koppelman GH; Saeys Y; Nawijn MC; Postma DS; Akdis M; Auffray C; Ballereau S; Benet M; García-Aymerich J; González JR; Guerra S; Keil T; Kogevinas M; Lambrecht B; Lemonnier N; Melen E; Sunyer J; Valenta R; Valverde S; Wickman M; Bousquet J; Oliva B; Antó JM, 2017. Computational analysis of multimorbidity between asthma, eczema and rhinitis.  PLoS One 12(6):e0179125

Osei ET; Florez-Sampedro L; Tasena H; Faiz A; Noordhoek JA; Timens W; Postma DS; Hackett TL; Heijink IH; Brandsma CA, 2017. miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD.  Eur Respir J 49.

Pouwels SD; Faiz A; den Boef LE; Gras R; van den Berge M; Boezen HM; Korstanje R; Ten Hacken NHT; van Oosterhout AJM; Heijink IH; Nawijn MC, 2017. Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.  Am J Physiol Lung Cell Mol Physiol 313(3):L559-L580

Harkness LM; Weckmann M; Kopp M; Becker T; Ashton AW; Burgess JK, 2017. Tumstatin regulates the angiogenic and inflammatory potential of airway smooth muscle extracellular matrix.  J Cell Mol Med 21(12):3288-3297

van Gisbergen MW; Voets AM; Biemans R; Hoffmann RF; Drittij-Reijnders MJ; Haenen GRMM; Heijink IH; Rouschop KMA; Dubois LJ; Lambin P, 2017. Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress.  PLoS One 12(8):e0182508

Liu G; Cooley MA; Nair PM; Donovan C; Hsu AC; Jarnicki AG; Haw TJ; Hansbro NG; Ge Q; Brown AC; Tay H; Foster PS; Wark PA; Horvat JC; Bourke JE; Grainge CL; Argraves WS; Oliver BG; Knight DA; Burgess JK; Hansbro PM, 2017. Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.  J Pathol 243(4):510-523

Murtha LA; Schuliga MJ; Mabotuwana NS; Hardy SA; Waters DW; Burgess JK; Knight DA; Boyle AJ, 2017. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis.  Front Physiol 8:777

Tjin G; White ES; Faiz A; Sicard D; Tschumperlin DJ; Mahar A; Kable EPW; Burgess JK, 2017. Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis.  Dis Model Mech 10(11):1301-1312

Boudewijn IM; Faiz A; Steiling K; van der Wiel E; Telenga ED; Hoonhorst SJM; Ten Hacken NHT; Brandsma CA; Kerstjens HAM; Timens W; Heijink IH; Jonker MR; de Bruin HG; Sebastiaan Vroegop J; Pasma HR; Boersma WG; Wielders P; van den Elshout F; Mansour K; Spira A; Lenburg ME; Guryev V; Postma DS; van den Berge M, 2017. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.  Respir Res 18(1):213

Pouwels SD; Zijlstra GJ; van der Toorn M; Hesse L; Gras R; Ten Hacken NH; Krysko DV; Vandenabeele P; de Vries M; van Oosterhout AJ; Heijink IH; Nawijn MC, 2016. Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice.  Am J Physiol Lung Cell Mol Physiol 310(4):L377-86

Heijink IH; Jonker MR; de Vries M; van Oosterhout AJ; Telenga E; Ten Hacken NH; Postma DS; van den Berge M, 2016. Budesonide and fluticasone propionate differentially affect the airway epithelial barrier.  Respir Res 17:2

Spanjer AI; Menzen MH; Dijkstra AE; van den Berge M; Boezen HM; Nickle DC; Sin DD; Bossé Y; Brandsma CA; Timens W; Postma DS; Meurs H; Heijink IH; Gosens R, 2016. A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.  Thorax 71(4):312-22

Spanjer AI; Baarsma HA; Oostenbrink LM; Jansen SR; Kuipers CC; Lindner M; Postma DS; Meurs H; Heijink IH; Gosens R; Königshoff M, 2016. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.  FASEB J 30(5):1823-35

Ketelaar ME; Nawijn MC; Shaw DE; Koppelman GH; Sayers I, 2016. The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma.  Clin Exp Allergy 46(6):884-7

Heijink IH; de Bruin HG; Dennebos R; Jonker MR; Noordhoek JA; Brandsma CA; van den Berge M; Postma DS, 2016. Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD.  Eur Respir J 48(2):504-15

Vries Md; Bedke N; Smithers NP; Loxham M; Howarth PH; Nawijn MC; Davies DE, 2016. Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations.  Eur Respir J 47(3):783-91

Liu G; Cooley MA; Jarnicki AG; Hsu AC; Nair PM; Haw TJ; Fricker M; Gellatly SL; Kim RY; Inman MD; Tjin G; Wark PA; Walker MM; Horvat JC; Oliver BG; Argraves WS; Knight DA; Burgess JK; Hansbro PM, 2016. Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.  JCI Insight 1.

Kim SY; Burgess JK; Wang Y; Kable EP; Weiss DJ; Chan HK; Chrzanowski W, 2016. Atomized Human Amniotic Mesenchymal Stromal Cells for Direct Delivery to the Airway for Treatment of Lung Injury.  J Aerosol Med Pulm Drug Deliv 29(6):514-524

Tang FS; Hansbro PM; Burgess JK; Ammit AJ; Baines KJ; Oliver BG, 2016. A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro.  Thorax 71(11):1039-1049

Osei ET; Noordhoek JA; Hackett TL; Spanjer AI; Postma DS; Timens W; Brandsma CA; Heijink IH, 2016. Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.  Eur Respir J 48(2):359-69

Faura Tellez G; Willemse BW; Brouwer U; Nijboer-Brinksma S; Vandepoele K; Noordhoek JA; Heijink I; de Vries M; Smithers NP; Postma DS; Timens W; Wiffen L; van Roy F; Holloway JW; Lackie PM; Nawijn MC; Koppelman GH, 2016. Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma.  PLoS One 11(10):e0163967

Burgess JK; Mauad T; Tjin G; Karlsson JC; Westergren-Thorsson G, 2016. The extracellular matrix - the under-recognized element in lung disease?  J Pathol 240(4):397-409

Pouwels SD; Hesse L; Faiz A; Lubbers J; Bodha PK; Ten Hacken NH; van Oosterhout AJ; Nawijn MC; Heijink IH, 2016. Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD.  Am J Physiol Lung Cell Mol Physiol 311(5):L881-L892

Schwarze J; Fitch PM; Heimweg J; Errington C; Matsuda R; de Bruin HG; van den Berge M; van Oosterhout AJ; Heijink IH, 2016. Viral mimic poly-(I:C) attenuates airway epithelial T-cell suppressive capacity: implications for asthma.  Eur Respir J 48(6):1785-1788

Van der Velden J; Harkness LM; Barker DM; Barcham GJ; Ugalde CL; Koumoundouros E; Bao H; Organ LA; Tokanovic A; Burgess JK; Snibson KJ, 2016. The Effects of Tumstatin on Vascularity, Airway Inflammation and Lung Function in an Experimental Sheep Model of Chronic Asthma.  Sci Rep 6:26309

de Vries M; Smithers NP; Howarth PH; Nawijn MC; Davies DE, 2015. Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells.  Eur Respir J 45(6):1745-8

Saluja R; Ketelaar ME; Hawro T; Church MK; Maurer M; Nawijn MC, 2015. The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders.  Mol Immunol 63(1):80-5

Bidad K; Nawijn MC; van Oosterhout AJ; van der Heide S; Oude Elberink JN, 2015. Basophil activation test in mastocytosis patients with and without wasp venom allergy.  Cytometry B Clin Cytom 88(1):5

Pouwels SD; Heijink IH; Brouwer U; Gras R; den Boef LE; Boezen HM; Korstanje R; van Oosterhout AJ; Nawijn MC, 2015. Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.  Am J Physiol Lung Cell Mol Physiol 308(7):L693-709

Poppinga WJ; Heijink IH; Holtzer LJ; Skroblin P; Klussmann E; Halayko AJ; Timens W; Maarsingh H; Schmidt M, 2015. A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.  Am J Physiol Lung Cell Mol Physiol 308(8):L766-75

Heijink IH; Rozeveld D; van der Heide S; van der Bij W; Bischoff R; van Oosterhout AJ; van der Toorn M, 2015. Metalloproteinase Profiling in Lung Transplant Recipients With Good Outcome and Bronchiolitis Obliterans Syndrome.  Transplantation 99(9):1946-52

Pouwels SD; Nawijn MC; Bathoorn E; Riezebos-Brilman A; van Oosterhout AJ; Kerstjens HA; Heijink IH, 2015. Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients.  Eur Respir J 45(5):1482-5

Matusiak N; van Waarde A; Rozeveld D; van Oosterhout AJ; Heijink IH; Castelli R; Overkleeft HS; Bischoff R; Dierckx RA; Elsinga PH, 2015. MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation.  Mol Imaging Biol 17(5):680-7

Faura Tellez G; Vandepoele K; Brouwer U; Koning H; Elderman RM; Hackett TL; Willemse BW; Holloway J; Van Roy F; Koppelman GH; Nawijn MC, 2015. Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription.  Am J Physiol Lung Cell Mol Physiol 309(7):L725-35

Osei ET; Florez-Sampedro L; Timens W; Postma DS; Heijink IH; Brandsma CA, 2015. Unravelling the complexity of COPD by microRNAs: it's a small world after all.  Eur Respir J 46(3):807-18

Post S; Rozeveld D; Jonker MR; Bischoff R; van Oosterhout AJ; Heijink IH, 2015. ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium.  Allergy 70(12):1545-52

Ngkelo A; Hoffmann RF; Durham AL; Marwick JA; Brandenburg SM; de Bruin HG; Jonker MR; Rossios C; Tsitsiou E; Caramori G; Contoli M; Casolari P; Monaco F; Andò F; Speciale G; Kilty I; Chung KF; Papi A; Lindsay MA; Ten Hacken NH; van den Berge M; Timens W; Barnes PJ; van Oosterhout AJ; Adcock IM; Kirkham PA; Heijink IH, 2015. Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.  Am J Physiol Lung Cell Mol Physiol 309(10):L1112-23

de Vries M; Hesse L; Jonker MR; van den Berge M; van Oosterhout AJ; Heijink IH; Nawijn MC, 2015. Pim1 kinase activity preserves airway epithelial integrity upon house dust mite exposure.  Am J Physiol Lung Cell Mol Physiol 309(11):L1344-53

Tang FS; Foxley GJ; Gibson PG; Burgess JK; Baines KJ; Oliver BG, 2015. Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma.  Mediators Inflamm 2015:219374

Zijlstra GJ; Fattahi F; Rozeveld D; Jonker MR; Kliphuis NM; van den Berge M; Hylkema MN; ten Hacken NH; van Oosterhout AJ; Heijink IH, 2014. Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium.  Eur Respir J 44(2):361-70

van den Berge M; Steiling K; Timens W; Hiemstra PS; Sterk PJ; Heijink IH; Liu G; Alekseyev YO; Lenburg ME; Spira A; Postma DS, 2014. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity.  Thorax 69(1):14-23

Pouwels SD; Heijink IH; van Oosterhout AJ; Nawijn MC, 2014. A specific DAMP profile identifies susceptibility to smoke-induced airway inflammation.  Eur Respir J 43(4):1183-6

Oldenburger A; Poppinga WJ; Kos F; de Bruin HG; Rijks WF; Heijink IH; Timens W; Meurs H; Maarsingh H; Schmidt M, 2014. A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke.  Am J Physiol Cell Physiol 306(6):C585-97

Bidad K; Nawijn MC; van Oosterhout AJ; van der Heide S; Elberink JN, 2014. Basophil activation test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy on immunotherapy.  Cytometry B Clin Cytom 86(3):183-90

Faura Tellez G; Nawijn MC; Koppelman GH, 2014. Protocadherin-1: Epithelial barrier dysfunction in asthma and eczema.  Eur Respir J 43(3):671-4

Heijink IH; Nawijn MC; Hackett TL, 2014. Airway epithelial barrier function regulates the pathogenesis of allergic asthma.  Clin Exp Allergy 44(5):620-30

Pouwels SD; Heijink IH; ten Hacken NH; Vandenabeele P; Krysko DV; Nawijn MC; van Oosterhout AJ, 2014. DAMPs activating innate and adaptive immune responses in COPD.  Mucosal Immunol 7(2):215-26

Post S; Heijink IH; Petersen AH; de Bruin HG; van Oosterhout AJ; Nawijn MC, 2014. Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice.  PLoS One 9(3):e91206

de Vries M; Heijink IH; Gras R; den Boef LE; Reinders-Luinge M; Pouwels SD; Hylkema MN; van der Toorn M; Brouwer U; van Oosterhout AJ; Nawijn MC, 2014. Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation.  Am J Physiol Lung Cell Mol Physiol 307(3):L240-51

Heijink IH; Noordhoek JA; Timens W; van Oosterhout AJ; Postma DS, 2014. Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease.  Am J Respir Crit Care Med 189(11):1439-42

Chen L; Ge Q; Tjin G; Alkhouri H; Deng L; Brandsma CA; Adcock I; Timens W; Postma D; Burgess JK; Black JL; Oliver BG, 2014. Effects of cigarette smoke extract on human airway smooth muscle cells in COPD.  Eur Respir J 44(3):634-46

Dijkstra AE; Smolonska J; van den Berge M; Wijmenga C; Zanen P; Luinge MA; Platteel M; Lammers JW; Dahlback M; Tosh K; Hiemstra PS; Sterk PJ; Spira A; Vestbo J; Nordestgaard BG; Benn M; Nielsen SF; Dahl M; Verschuren WM; Picavet HS; Smit HA; Owsijewitsch M; Kauczor HU; de Koning HJ; Nizankowska-Mogilnicka E; Mejza F; Nastalek P; van Diemen CC; Cho MH; Silverman EK; Crapo JD; Beaty TH; Lomas DA; Bakke P; Gulsvik A; Bossé Y; Obeidat M; Loth DW; Lahousse L; Rivadeneira F; Uitterlinden AG; Hofman A; Stricker BH; Brusselle GG; van Duijn CM; Brouwer U; Koppelman GH; Vonk JM; Nawijn MC; Groen HJ; Timens W; Boezen HM; Postma DS, 2014. Susceptibility to chronic mucus hypersecretion, a genome wide association study.  PLoS One 9(4):e91621

Koning H; van Oosterhout AJ; Brouwer U; den Boef LE; Gras R; Reinders-Luinge M; Brandsma CA; van der Toorn M; Hylkema MN; Willemse BW; Sayers I; Koppelman GH; Nawijn MC, 2014. Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.  PLoS One 9(7):e98197

Burgess JK; Gosens R, 2014. Airway Smooth Muscle and Fibroblast Biology still a leading research focus for Young Investigators in the field.  Pulm Pharmacol Ther 29(2):91-2

Boorsma CE; Dekkers BG; van Dijk EM; Kumawat K; Richardson J; Burgess JK; John AE, 2014. Beyond TGFβ--novel ways to target airway and parenchymal fibrosis.  Pulm Pharmacol Ther 29(2):166-80

Kistemaker LE; Bos IS; Hylkema MN; Nawijn MC; Hiemstra PS; Wess J; Meurs H; Kerstjens HA; Gosens R, 2013. Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.  Eur Respir J 42(6):1677-88

Heijink IH; de Bruin HG; van den Berge M; Bennink LJ; Brandenburg SM; Gosens R; van Oosterhout AJ; Postma DS, 2013. Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease.  Thorax 68(8):709-16

Grotenboer NS; Ketelaar ME; Koppelman GH; Nawijn MC, 2013. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology.  J Allergy Clin Immunol 131(3):856-65

Nawijn MC; Motta AC; Gras R; Shirinbak S; Maazi H; van Oosterhout AJ, 2013. TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice.  PLoS One 8(2):e55307

Maazi H; Shirinbak S; den Boef LE; Fallarino F; Volpi C; Nawijn MC; van Oosterhout AJ, 2013. Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy.  Clin Exp Immunol 172(1):113-20

Post S; Nawijn MC; Jonker MR; Kliphuis N; van den Berge M; van Oosterhout AJ; Heijink IH, 2013. House dust mite-induced calcium signaling instigates epithelial barrier dysfunction and CCL20 production.  Allergy 68(9):1117-25

Heijink IH; van den Berge M, 2013. Are salmeterol's beneficial effects on corticosteroid action in the airways executed at the epithelial barrier?  Respirology 18(8):1165-6

Hoffmann RF; Zarrintan S; Brandenburg SM; Kol A; de Bruin HG; Jafari S; Dijk F; Kalicharan D; Kelders M; Gosker HR; Ten Hacken NH; van der Want JJ; van Oosterhout AJ; Heijink IH, 2013. Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells.  Respir Res 14(1):97

Bidad K; Nawijn MC; van Oosterhout AJ; van der Heide S; Elberink JN, 2013. Basophil Activation Test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy.  Cytometry B Clin Cytom.

Maazi H; Shirinbak S; Willart M; Hammad HM; Cabanski M; Boon L; Ganesh V; Baru AM; Hansen G; Lambrecht BN; Sparwasser T; Nawijn MC; van Oosterhout AJ, 2012. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy.  Clin Exp Allergy 42(10):1519-28

Post S; Nawijn MC; Hackett TL; Baranowska M; Gras R; van Oosterhout AJ; Heijink IH, 2012. The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation.  Thorax 67(6):488-95

Koning H; Sayers I; Stewart CE; de Jong D; Ten Hacken NH; Postma DS; van Oosterhout AJ; Nawijn MC; Koppelman GH, 2012. Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.  FASEB J 26(1):439-48

Zijlstra GJ; Ten Hacken NH; Hoffmann RF; van Oosterhout AJ; Heijink IH, 2012. Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells.  Eur Respir J 39(2):439-45

Heijink IH; Brandenburg SM; Postma DS; van Oosterhout AJ, 2012. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery.  Eur Respir J 39(2):419-28

Nawijn MC; Hackett TL; Postma DS; van Oosterhout AJ; Heijink IH, 2011. E-cadherin: gatekeeper of airway mucosa and allergic sensitization.  Trends Immunol 32(6):248-55

Nawijn MC; Piavaux BJ; Jeurink PV; Gras R; Reinders MA; Stearns T; Foote S; Hylkema MN; Groot PC; Korstanje R; Oosterhout AJ, 2011. Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.  Am J Respir Cell Mol Biol 45(2):295-303

Nawijn MC; Alendar A; Berns A, 2011. For better or for worse: the role of Pim oncogenes in tumorigenesis.  Nat Rev Cancer 11(1):23-34

Koppelman GH; Nawijn MC, 2011. Recent advances in the epigenetics and genomics of asthma.  Curr Opin Allergy Clin Immunol 11(5):414-9

Van Hemelen D; Oude Elberink JN; Bohle B; Heimweg J; Nawijn MC; van Oosterhout AJ, 2011. Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures.  J Immunol Methods 371(1-2):114-21

Heijink IH; Brandenburg SM; Noordhoek JA; Slebos DJ; Postma DS; van Oosterhout AJ, 2011. Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.  Respir Res 12(1):110

Maazi H; Shirinbak S; Bloksma N; Nawijn MC; van Oosterhout AJ, 2011. Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.  Clin Exp Immunol 166(1):80-6

Shirinbak S; Taher YA; Maazi H; Gras R; van Esch BC; Henricks PA; Samsom JN; Verbeek JS; Lambrecht BN; van Oosterhout AJ; Nawijn MC, 2010. Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice.  J Immunol 185(7):3857-65

Heijink IH; van Oosterhout A; Kapus A, 2010. Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction.  Eur Respir J 36(5):1016-26

Gosens R; Baarsma HA; Heijink IH; Oenema TA; Halayko AJ; Meurs H; Schmidt M, 2010. De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth.  FASEB J 24(3):757-68

Heijink IH; Brandenburg SM; Noordhoek JA; Postma DS; Slebos DJ; van Oosterhout AJ, 2010. Characterisation of cell adhesion in airway epithelial cell types using electric cell-substrate impedance sensing.  Eur Respir J 35(4):894-903

Heijink IH; Postma DS; Noordhoek JA; Broekema M; Kapus A, 2010. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium.  Am J Respir Cell Mol Biol 42(1):69-79

Motta AC; Vissers JL; Gras R; Van Esch BC; Van Oosterhout AJ; Nawijn MC, 2009. GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma.  Respir Res 10(1):93

Heijink IH; Kauffman HF; Vellenga E; Veltman-Starkenburg CA; Postma DS; de Monchy JG, 2008. Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma.  Int Arch Allergy Immunol 145(2):111-21

Heijink IH; Kies PM; Kauffman HF; Postma DS; van Oosterhout AJ; Vellenga E, 2007. Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity.  J Immunol 178(12):7678-85

Heijink IH; Marcel Kies P; van Oosterhout AJ; Postma DS; Kauffman HF; Vellenga E, 2007. Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium.  Am J Respir Cell Mol Biol 36(3):351-9

Heijink IH; Van Oosterhout AJ, 2006. Strategies for targeting T-cells in allergic diseases and asthma.  Pharmacol Ther 112(2):489-500

Heijink IH; Van Oosterhout AJ, 2005. Targeting T cells for asthma.  Curr Opin Pharmacol 5(3):227-31

Heijink IH; Vellenga E; Oostendorp J; de Monchy JG; Postma DS; Kauffman HF, 2005. Exposure to TARC alters beta2-adrenergic receptor signaling in human peripheral blood T lymphocytes.  Am J Physiol Lung Cell Mol Physiol 289(1):L53-9

Heijink IH; van den Berge M; Vellenga E; de Monchy JG; Postma DS; Kauffman HF, 2004. Altered beta2-adrenergic regulation of T cell activity after allergen challenge in asthma.  Clin Exp Allergy 34(9):1356-63

Heijink IH; Kauffman HF; Postma DS; de Monchy JG; Vellenga E, 2003. Sensitivity of IL-5 production to the cAMP-dependent pathway in human T cells is reduced by exogenous IL-2 in a phosphoinositide 3-kinase-dependent way.  Eur J Immunol 33(8):2206-15

Heijink IH; Vellenga E; Borger P; Postma DS; Monchy JG; Kauffman HF, 2003. Polarized Th1 and Th2 cells are less responsive to negative feedback by receptors coupled to the AC/cAMP system compared to freshly isolated T cells.  Br J Pharmacol 138(8):1441-50

Heijink IH; Vellenga E; Borger P; Postma DS; de Monchy JG; Kauffman HF, 2002. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells.  Immunology 107(3):316-24

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