Or Publications list 1 ?
Below a list of publications found on Pubmed where members of our group where (co)author on:
Martinez-Garcia FD; de Hilster RHJ; Sharma PK; Borghuis T; Hylkema MN; Burgess JK; Harmsen MC, 2021. Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels. Polymers (Basel) 13.
Heijink IH; Hackett TL; Pouwels SD, 2021. Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium†. J Pathol 253(4):351-354
Hu S; Martinez-Garcia FD; Moeun BN; Burgess JK; Harmsen MC; Hoesli C; de Vos P, 2021. An immune regulatory 3D-printed alginate-pectin construct for immunoisolation of insulin producing β-cells. Mater Sci Eng C Mater Biol Appl 123:112009
Liu G; Philp AM; Corte T; Travis MA; Schilter H; Hansbro NG; Burns CJ; Eapen MS; Sohal SS; Burgess JK; Hansbro PM, 2021. Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacol Ther 225:107839
Kruk DMLW; Wisman M; Bruin HG; Lodewijk ME; Hof DJ; Borghuis T; Daamen WF; van Kuppevelt TH; Timens W; Burgess JK; Ten Hacken NHT; Heijink IH, 2021. Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema. Am J Physiol Lung Cell Mol Physiol 320(5):L832-L844
Muus C; Luecken MD; Eraslan G; Sikkema L; Waghray A; Heimberg G; Kobayashi Y; Vaishnav ED; Subramanian A; Smillie C; Jagadeesh KA; Duong ET; Fiskin E; Triglia ET; Ansari M; Cai P; Lin B; Buchanan J; Chen S; Shu J; Haber AL; Chung H; Montoro DT; Adams T; Aliee H; Allon SJ; Andrusivova Z; Angelidis I; Ashenberg O; Bassler K; Bécavin C; Benhar I; Bergenstråhle J; Bergenstråhle L; Bolt L; Braun E; Bui LT; Callori S; Chaffin M; Chichelnitskiy E; Chiou J; Conlon TM; Cuoco MS; Cuomo ASE; Deprez M; Duclos G; Fine D; Fischer DS; Ghazanfar S; Gillich A; Giotti B; Gould J; Guo M; Gutierrez AJ; Habermann AC; Harvey T; He P; Hou X; Hu L; Hu Y; Jaiswal A; Ji L; Jiang P; Kapellos TS; Kuo CS; Larsson L; Leney-Greene MA; Lim K; Litviňuková M; Ludwig LS; Lukassen S; Luo W; Maatz H; Madissoon E; Mamanova L; Manakongtreecheep K; Leroy S; Mayr CH; Mbano IM; McAdams AM; Nabhan AN; Nyquist SK; Penland L; Poirion OB; Poli S; Qi C; Queen R; Reichart D; Rosas I; Schupp JC; Shea CV; Shi X; Sinha R; Sit RV; Slowikowski K; Slyper M; Smith NP; Sountoulidis A; Strunz M; Sullivan TB; Sun D; Talavera-López C; Tan P; Tantivit J; Travaglini KJ; Tucker NR; Vernon KA; Wadsworth MH; Waldman J; Wang X; Xu K; Yan W; Zhao W; Ziegler CGK, 2021. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med 27(3):546-559
Kortekaas RK; Burgess JK; van Orsoy R; Lamb D; Webster M; Gosens R, 2021. Therapeutic Targeting of IL-11 for Chronic Lung Disease. Trends Pharmacol Sci 42(5):354-366
Vasse GF; Nizamoglu M; Heijink IH; Schlepütz M; van Rijn P; Thomas MJ; Burgess JK; Melgert BN, 2021. Macrophage-stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives. J Pathol 254(4):344-357
Xu CJ; Gruzieva O; Qi C; Esplugues A; Gehring U; Bergström A; Mason D; Chatzi L; Porta D; Lodrup Carlsen KC; Baïz N; Madore AM; Alenius H; van Rijkom B; Jankipersadsing SA; van der Vlies P; Kull I; van Hage M; Bustamante M; Lertxundi A; Torrent M; Santorelli G; Fantini MP; Hovland V; Pesce G; Fyhrquist N; Laatikainen T; Nawijn MC; Li Y; Wijmenga C; Netea MG; Bousquet J; Anto JM; Laprise C; Haahtela T; Annesi-Maesano I; Carlsen KH; Gori D; Kogevinas M; Wright J; Söderhäll C; Vonk JM; Sunyer J; Melén E; Koppelman GH, 2021. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol 147(3):1031-1040
Koloko Ngassie ML; Brandsma CA; Gosens R; Prakash YS; Burgess JK, 2021. The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête. Physiology (Bethesda) 36(3):150-159
Ketelaar ME; Westerlaken-van Ginkel CD; Nawijn MC; Ej Dubois A; Koppelman GH, 2021. IL-1RL1a serum levels and IL1RL1 SNPs in the prediction of food allergy. Clin Exp Allergy 51(4):614-619
Woldhuis RR; Heijink IH; van den Berge M; Timens W; Oliver BGG; de Vries M; Brandsma CA, 2021. COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins. Thorax 76(5):508-511
Martinez-Garcia FD; Valk MM; Sharma PK; Burgess JK; Harmsen MC, 2021. Adipose Tissue-Derived Stromal Cells Alter the Mechanical Stability and Viscoelastic Properties of Gelatine Methacryloyl Hydrogels. Int J Mol Sci 22.
Hesse L; Petersen AH; Nawijn MC, 2021. Methods for Experimental Allergen Immunotherapy: Subcutaneous and Sublingual Desensitization in Mouse Models of Allergic Asthma. Methods Mol Biol 2223:295-335
Burgess JK; Jonker MR; Berg M; Ten Hacken NTH; Meyer KB; van den Berge M; Nawijn MC; Heijink IH, 2021. Periostin: contributor to abnormal airway epithelial function in asthma? Eur Respir J 57.
Ketelaar ME; Portelli MA; Dijk FN; Shrine N; Faiz A; Vermeulen CJ; Xu CJ; Hankinson J; Bhaker S; Henry AP; Billington CK; Shaw DE; Johnson SR; Benest AV; Pang V; Bates DO; Pogson ZEK; Fogarty A; McKeever TM; Singapuri A; Heaney LG; Mansur AH; Chaudhuri R; Thomson NC; Holloway JW; Lockett GA; Howarth PH; Niven R; Simpson A; Tobin MD; Hall IP; Wain LV; Blakey JD; Brightling CE; Obeidat M; Sin DD; Nickle DC; Bossé Y; Vonk JM; van den Berge M; Koppelman GH; Sayers I; Nawijn MC, 2021. Phenotypic and functional translation of IL33 genetics in asthma. J Allergy Clin Immunol 147(1):144-157
Saikumar Jayalatha AK; Hesse L; Ketelaar ME; Koppelman GH; Nawijn MC, 2021. The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention. Pharmacol Ther 225:107847
Dwyer DF; Ordovas-Montanes J; Allon SJ; Buchheit KM; Vukovic M; Derakhshan T; Feng C; Lai J; Hughes TK; Nyquist SK; Giannetti MP; Berger B; Bhattacharyya N; Roditi RE; Katz HR; Nawijn MC; Berg M; van den Berge M; Laidlaw TM; Shalek AK; Barrett NA; Boyce JA, 2021. Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol 6.
van de Wetering C; Elko E; Berg M; Schiffers CHJ; Stylianidis V; van den Berge M; Nawijn MC; Wouters EFM; Janssen-Heininger YMW; Reynaert NL, 2021. Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility? Redox Biol 43:101995
Ter Ellen BM; Dinesh Kumar N; Bouma EM; Troost B; van de Pol DPI; van der Ende-Metselaar HH; Apperloo L; van Gosliga D; van den Berge M; Nawijn MC; van der Voort PHJ; Moser J; Rodenhuis-Zybert IA; Smit JM, 2021. Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells. Viruses 13.
Waters DW; Schuliga M; Pathinayake PS; Wei L; Tan HY; Blokland KEC; Jaffar J; Westall GP; Burgess JK; Prêle CM; Mutsaers SE; Grainge CL; Knight DA, 2021. A Senescence Bystander Effect in Human Lung Fibroblasts. Biomedicines 9.
Schuliga M; Kanwal A; Read J; Blokland KEC; Burgess JK; Prêle CM; Mutsaers SE; Grainge C; Thomson C; James A; Bartlett NW; Knight DA, 2021. A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: A potential drug target in IPF. Am J Physiol Lung Cell Mol Physiol.
van der Ploeg EA; Melgert BN; Burgess JK; Gan CT, 2021. The potential of biomarkers of fibrosis in chronic lung allograft dysfunction. Transplant Rev (Orlando) 35(3):100626
Roffel MP; Boudewijn IM; van Nijnatten JLL; Faiz A; Vermeulen CJ; van Oosterhout AJ; Affleck K; Timens W; Bracke KR; Maes T; Heijink IH; Brandsma CA; van den Berge M, 2021. Identification of asthma associated microRNAs in bronchial biopsies. Eur Respir J.
Chen Q; Heijink IH; de Vries M, 2021. Connecting GWAS Susceptibility Genes in COPD: Do We Need to Consider TGF-β2? Am J Respir Cell Mol Biol.
Pouwels SD; Hesse L; Wu X; Allam VSRR; van Oldeniel D; Bhiekharie LJ; Phipps S; Oliver BG; Gosens R; Sukkar MB; Heijink IH, 2021. LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE. Am J Physiol Lung Cell Mol Physiol 321(4):L641-L652
Vasse GF; Van Os L; De Jager M; Jonker MR; Borghuis T; Van Den Toorn LT; Jellema P; White ES; Van Rijn P; Harmsen MC; Heijink IH; Melgert BN; Burgess JK, 2021. Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices. Front Pharmacol 12:669037
Kuchibhotla VNS; Starkey MR; Reid AT; Heijink IH; Nawijn MC; Hansbro PM; Knight DA, 2021. Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice. Front Physiol 12:690531
Weckmann M; Bahmer T; Bülow Sand JM; Rank Rønnow S; Pech M; Vermeulen C; Faiz A; Leeming DJ; Karsdal MA; Lunding L; Oliver BGG; Wegmann M; Ulrich-Merzenich G; Juergens UR; Duhn J; Laumonnier Y; Danov O; Sewald K; Zissler U; Jonker M; König I; Hansen G; von Mutius E; Fuchs O; Dittrich AM; Schaub B; Happle C; Rabe KF; van de Berge M; Burgess JK; Kopp MV, 2021. COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J.
Blokland KEC; Habibie H; Borghuis T; Teitsma GJ; Schuliga M; Melgert BN; Knight DA; Brandsma CA; Pouwels SD; Burgess JK, 2021. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM. Cells 10.
Chen Q; de Vries M; Nwozor KO; Noordhoek JA; Brandsma CA; Boezen HM; Heijink IH, 2021. A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract. Front Physiol 12:690936
Schiller HB; van Breugel M; Nawijn MC, 2021. SARS-CoV-2-specific hotspots in virus-host interaction networks. Nat Immunol 22(7):806-808
Faiz A; Harkness LM; Tjin G; Bernal V; Horvatovich P; James A; Elliot JG; Burgess JK; Ashton AW, 2021. Angiogenic regulatory influence of extracellular matrix deposited by resting state asthmatic and non-asthmatic airway smooth muscle cells is similar. J Cell Mol Med.
Nemani SSP; Vermeulen CJ; Pech M; Faiz A; Oliver BGG; van den Berge M; Burgess JK; Kopp MV; Weckmann M, 2021. COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding. ERJ Open Res 7.
Schupp JC; Adams TS; Cosme C Jr; Raredon MSB; Yuan Y; Omote N; Poli S; Chioccioli M; Rose KA; Manning EP; Sauler M; DeIuliis G; Ahangari F; Neumark N; Habermann AC; Gutierrez AJ; Bui LT; Lafyatis R; Pierce RW; Meyer KB; Nawijn MC; Teichmann SA; Banovich NE; Kropski JA; Niklason LE; Pe'er D; Yan X; Homer RJ; Rosas IO; Kaminski N, 2021. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 144(4):286-302
Qi C; Jiang Y; Yang IV; Forno E; Wang T; Vonk JM; Gehring U; Smit HA; Milanzi EB; Carpaij OA; Berg M; Hesse L; Brouwer S; Cardwell J; Vermeulen CJ; Acosta-Pérez E; Canino G; Boutaoui N; van den Berge M; Teichmann SA; Nawijn MC; Chen W; Celedón JC; Xu CJ; Koppelman GH, 2020. Nasal DNA methylation profiling of asthma and rhinitis. J Allergy Clin Immunol 145(6):1655-1663
van der Wijst M; de Vries DH; Groot HE; Trynka G; Hon CC; Bonder MJ; Stegle O; Nawijn MC; Idaghdour Y; van der Harst P; Ye CJ; Powell J; Theis FJ; Mahfouz A; Heinig M; Franke L, 2020. The single-cell eQTLGen consortium. Elife 9.
Ali MK; Kim RY; Brown AC; Donovan C; Vanka KS; Mayall JR; Liu G; Pillar AL; Jones-Freeman B; Xenaki D; Borghuis T; Karim R; Pinkerton JW; Aryal R; Heidari M; Martin KL; Burgess JK; Oliver BG; Trinder D; Johnstone DM; Milward EA; Hansbro PM; Horvat JC, 2020. Critical role for iron accumulation in the pathogenesis of fibrotic lung disease. J Pathol 251(1):49-62
de Hilster RHJ; Sharma PK; Jonker MR; White ES; Gercama EA; Roobeek M; Timens W; Harmsen MC; Hylkema MN; Burgess JK, 2020. Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue. Am J Physiol Lung Cell Mol Physiol 318(4):L698-L704
Zuo H; Trombetta-Lima M; Heijink IH; van der Veen CHTJ; Hesse L; Faber KN; Poppinga WJ; Maarsingh H; Nikolaev VO; Schmidt AM, 2020. A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition. Cells 9.
Kuchibhotla VNS; Jonker MR; de Bruin HG; Noordhoek JA; Knight DA; Nawijn MC; Heijink IH, 2020. Inhibition of β-catenin/CBP signalling improves airway epithelial barrier function and suppresses CCL20 release. Allergy 75(7):1786-1789
Boudewijn IM; Lan A; Faiz A; Cox CA; Brouwer S; Schokker S; Vroegop SJ; Nawijn MC; Woodruff PG; Christenson SA; Hagedoorn P; Frijlink HW; Choy DF; Brouwer U; Wisman M; Postma DS; Fingleton J; Beasley R; van den Berge M; Guryev V, 2020. Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy 75(1):191-194
Dijk FN; Vijverberg SJ; Hernandez-Pacheco N; Repnik K; Karimi L; Mitratza M; Farzan N; Nawijn MC; Burchard EG; Engelkes M; Verhamme KM; Potočnik U; Pino-Yanes M; Postma DS; Maitland-van der Zee AH; Koppelman GH, 2020. IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy 75(4):984-989
Osei ET; Brandsma CA; Timens W; Heijink IH; Hackett TL, 2020. Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD. Eur Respir J 55.
Vermeulen CJ; Xu CJ; Vonk JM; Ten Hacken NHT; Timens W; Heijink IH; Nawijn MC; Boekhoudt J; van Oosterhout AJ; Affleck K; Weckmann M; Koppelman GH; van den Berge M, 2020. Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission. Eur Respir J 55.
Aghapour M; Remels AHV; Pouwels SD; Bruder D; Hiemstra PS; Cloonan SM; Heijink IH, 2020. Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 318(1):L149-L164
Zuo H; Faiz A; van den Berge M; Mudiyanselage SNHR; Borghuis T; Timens W; Nikolaev VO; Burgess JK; Schmidt M, 2020. Cigarette smoke exposure alters phosphodiesterases in human structural lung cells. Am J Physiol Lung Cell Mol Physiol 318(1):L59-L64
Tasena H; Boudewijn IM; Faiz A; Timens W; Hylkema MN; Berg M; Ten Hacken NHT; Brandsma CA; Heijink IH; van den Berge M, 2020. MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease. Allergy 75(3):703-706
Blais-Lecours P; Laouafa S; Arias-Reyes C; Santos WL; Joseph V; Burgess JK; Halayko AJ; Soliz J; Marsolais D, 2020. Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis. Am J Respir Cell Mol Biol 62(1):35-42
Kuchibhotla VNS; Heijink IH, 2020. Join or Leave the Club: Jagged1 and Notch2 Dictate the Fate of Airway Epithelial Cells. Am J Respir Cell Mol Biol 63(1):4-6
Ubags ND; Baker J; Boots A; Costa R; El-Merhie N; Fabre A; Faiz A; Heijink IH; Hiemstra PS; Lehmann M; Meiners S; Rolandsson Enes S; Bartel S, 2020. ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. ERJ Open Res 6.
Boudewijn IM; Roffel MP; Vermeulen CJ; Nawijn MC; Kok K; Terpstra MM; Koppelman GH; Guryev V; van den Berge M, 2020. A Novel Role for Bronchial MicroRNAs and Long Noncoding RNAs in Asthma Remission. Am J Respir Crit Care Med 202(4):614-618
Koopmans T; Hesse L; Nawijn MC; Kumawat K; Menzen MH; Sophie T Bos I; Smits R; Bakker ERM; van den Berge M; Koppelman GH; Guryev V; Gosens R, 2020. Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation. Sci Rep 10(1):6754
Hesse L; Petersen AH; Oude Elberink JNG; van Oosterhout AJM; Nawijn MC, 2020. 1,25(OH)2VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model. Sci Rep 10(1):8960
Blokland KEC; Pouwels SD; Schuliga M; Knight DA; Burgess JK, 2020. Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases. Clin Sci (Lond) 134(20):2681-2706
Jiang J; Faiz A; Berg M; Carpaij OA; Vermeulen CJ; Brouwer S; Hesse L; Teichmann SA; Ten Hacken NHT; Timens W; van den Berge M; Nawijn MC, 2020. Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma. Clin Exp Allergy 50(12):1428-1431
Portelli MA; Dijk FN; Ketelaar ME; Shrine N; Hankinson J; Bhaker S; Grotenboer NS; Obeidat M; Henry AP; Billington CK; Shaw D; Johnson SR; Pogson ZE; Fogarty A; McKeever TM; Nickle DC; Bossé Y; van den Berge M; Faiz A; Brouwer S; Vonk JM; de Vos P; Brandsma CA; Vermeulen CJ; Singapuri A; Heaney LG; Mansur AH; Chaudhuri R; Thomson NC; Holloway JW; Lockett GA; Howarth PH; Niven R; Simpson A; Blakey JD; Tobin MD; Postma DS; Hall IP; Wain LV; Nawijn MC; Brightling CE; Koppelman GH; Sayers I, 2020. Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI Insight 5.
Nawijn MC; Timens W, 2020. Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19? Mol Syst Biol 16(7):e9841
Roffel MP; Bracke KR; Heijink IH; Maes T, 2020. miR-223: A Key Regulator in the Innate Immune Response in Asthma and COPD. Front Med (Lausanne) 7:196
Woldhuis RR; de Vries M; Timens W; van den Berge M; Demaria M; Oliver BGG; Heijink IH; Brandsma CA, 2020. Link between increased cellular senescence and extracellular matrix changes in COPD. Am J Physiol Lung Cell Mol Physiol 319(1):L48-L60
Marsh EK; Prestwich EC; Williams L; Hart AR; Muir CF; Parker LC; Jonker MR; Heijink IH; Timens W; Fife M; Hussell T; Hershenson MB; Bentley JK; Sun SC; Barksby BS; Borthwick LA; Stewart JP; Sabroe I; Dockrell DH; Marriott HM, 2020. Pellino-1 Regulates the Responses of the Airway to Viral Infection. Front Cell Infect Microbiol 10:456
Heijink IH; Kuchibhotla VNS; Roffel MP; Maes T; Knight DA; Sayers I; Nawijn MC, 2020. Epithelial cell dysfunction, a major driver of asthma development. Allergy 75(8):1902-1917
Osei ET; B Mostaço-Guidolin L; Hsieh A; Warner SM; Al-Fouadi M; Wang M; Cole DJ; Maksym GN; S Hallstrand T; Timens W; Brandsma CA; Heijink IH; Hackett TL, 2020. Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma. Sci Rep 10(1):8721
Carpaij OA; Goorsenberg AWM; d'Hooghe JNS; de Bruin DM; van den Elzen RM; Nawijn MC; Annema JT; van den Berge M; Bonta PI; Burgess JK, 2020. Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall. Am J Respir Crit Care Med 202(5):762-766
Blokland KEC; Waters DW; Schuliga M; Read J; Pouwels SD; Grainge CL; Jaffar J; Westall G; Mutsaers SE; Prêle CM; Burgess JK; Knight DA, 2020. Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing. Pharmaceutics 12.
Hesse L; van Ieperen N; Petersen AH; Elberink JNGO; van Oosterhout AJM; Nawijn MC, 2020. High dose vitamin D3 empowers effects of subcutaneous immunotherapy in a grass pollen-driven mouse model of asthma. Sci Rep 10(1):20876
Sungnak W; Huang N; Bécavin C; Berg M; Queen R; Litvinukova M; Talavera-López C; Maatz H; Reichart D; Sampaziotis F; Worlock KB; Yoshida M; Barnes JL, 2020. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med 26(5):681-687
Faiz A; Imkamp K; van der Wiel E; Boudewijn IM; Koppelman GH; Brandsma CA; Kerstjens HAM; Timens W; Vroegop S; Pasma HR; Boersma WG; Wielders P; van den Elshout F; Mansour K; Steiling K; Spira A; Lenburg ME; Heijink IH; Postma DS; van den Berge M, 2020. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Sci Rep 10(1):17415
Mostaço-Guidolin LB; Osei ET; Ullah J; Hajimohammadi S; Fouadi M; Li X; Li V; Shaheen F; Yang CX; Chu F; Cole DJ; Brandsma CA; Heijink IH; Maksym GN; Walker D; Hackett TL, 2019. Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma. Am J Respir Crit Care Med 200(4):431-443
Hulina-Tomašković A; Heijink IH; Jonker MR; Somborac-Bačura A; Grdić Rajković M; Rumora L, 2019. Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients. Biochimie 156:47-58
Taylor DM; Aronow BJ; Tan K; Bernt K; Salomonis N; Greene CS; Frolova A; Henrickson SE; Wells A; Pei L; Jaiswal JK; Whitsett J; Hamilton KE; MacParland SA; Kelsen J; Heuckeroth RO; Potter SS; Vella LA; Terry NA; Ghanem LR; Kennedy BC; Helbig I; Sullivan KE; Castelo-Soccio L; Kreigstein A; Herse F; Nawijn MC; Koppelman GH; Haendel M; Harris NL; Rokita JL; Zhang Y; Regev A; Rozenblatt-Rosen O; Rood JE; Tickle TL; Vento-Tormo R; Alimohamed S; Lek M; Mar JC; Loomes KM; Barrett DM; Uapinyoying P; Beggs AH; Agrawal PB; Chen YW; Muir AB; Garmire LX; Snapper SB; Nazarian J; Seeholzer SH; Fazelinia H; Singh LN; Faryabi RB; Raman P; Dawany N; Xie HM; Devkota B; Diskin SJ; Anderson SA; Rappaport EF; Peranteau W; Wikenheiser-Brokamp KA; Teichmann S; Wallace D; Peng T; Ding YY; Kim MS; Xing Y; Kong SW; Bönnemann CG; Mandl KD; White PS, 2019. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Dev Cell 49(1):10-29
Carpaij OA; Vonk JM; Nawijn MC; Kerstjens HAM; Koppelman GH; van den Berge M, 2019. Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies. J Allergy Clin Immunol 143(5):1973-1975
Faiz A; Steiling K; Roffel MP; Postma DS; Spira A; Lenburg ME; Borggrewe M; Eijgenraam TR; Jonker MR; Koppelman GH; Pouwels SD; Liu G; Alekseyev YO; Lam S; Hiemstra PS; Sterk PJ; Timens W; Brandsma CA; Heijink IH; van den Berge M, 2019. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J 53.
Waters DW; Blokland KEC; Pathinayake PS; Wei L; Schuliga M; Jaffar J; Westall GP; Hansbro PM; Prele CM; Mutsaers SE; Bartlett NW; Burgess JK; Grainge CL; Knight DA, 2019. STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts. Am J Respir Cell Mol Biol 61(1):61-73
Burgess JK; Weckmann M; Karsdal MA, 2019. The message from the matrix-should we listen more closely? J Thorac Dis 11(Suppl 3):S230-S233
Schiller HB; Montoro DT; Simon LM; Rawlins EL; Meyer KB; Strunz M; Vieira Braga FA; Timens W; Koppelman GH; Budinger GRS; Burgess JK; Waghray A; van den Berge M; Theis FJ; Regev A; Kaminski N; Rajagopal J; Teichmann SA; Misharin AV; Nawijn MC, 2019. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. Am J Respir Cell Mol Biol 61(1):31-41
Hesse L; Feenstra R; Ambrosini M; de Jager WA; Petersen A; Vietor H; Unger WWJ; van Kooyk Y; Nawijn MC, 2019. Subcutaneous immunotherapy using modified Phl p5a-derived peptides efficiently alleviates allergic asthma in mice. Allergy 74(12):2495-2498
Murtha LA; Morten M; Schuliga MJ; Mabotuwana NS; Hardy SA; Waters DW; Burgess JK; Ngo DT; Sverdlov AL; Knight DA; Boyle AJ, 2019. The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis. Aging Dis 10(2):419-428
Nikolić MZ; Garrido-Martin EM; Greiffo FR; Fabre A; Heijink IH; Boots A; Greene CM; Hiemstra PS; Bartel S, 2019. From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science." ERJ Open Res 5.
Vieira Braga FA; Kar G; Berg M; Carpaij OA; Polanski K; Simon LM; Brouwer S; Gomes T; Hesse L; Jiang J; Fasouli ES; Efremova M; Vento-Tormo R; Talavera-López C; Jonker MR; Affleck K; Palit S; Strzelecka PM; Firth HV; Mahbubani KT; Cvejic A; Meyer KB; Saeb-Parsy K; Luinge M; Brandsma CA; Timens W; Angelidis I; Strunz M; Koppelman GH; van Oosterhout AJ; Schiller HB; Theis FJ; van den Berge M; Nawijn MC; Teichmann SA, 2019. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat Med 25(7):1153-1163
Liu G; Cooley MA; Jarnicki AG; Borghuis T; Nair PM; Tjin G; Hsu AC; Haw TJ; Fricker M; Harrison CL; Jones B; Hansbro NG; Wark PA; Horvat JC; Argraves WS; Oliver BG; Knight DA; Burgess JK; Hansbro PM, 2019. Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis. JCI Insight 5.
Schenk HM; van Ockenburg SL; Nawijn MC; De Jonge P; Rosmalen JGM, 2019. Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study. PLoS One 14(9):e0221993
Hoffmann RF; Jonker MR; Brandenburg SM; de Bruin HG; Ten Hacken NHT; van Oosterhout AJM; Heijink IH, 2019. Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium. Sci Rep 9(1):15047
Carpaij OA; Muiser S; Bell AJ; Kerstjens HAM; Galban CJ; Fortuna AB; Siddiqui S; Olin AC; Nawijn MC; van den Berge M, 2019. Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air. ERJ Open Res 5.
Imkamp K; Bernal V; Grzegorzcyk M; Horvatovich P; Vermeulen CJ; Heijink IH; Guryev V; Kerstjens HAM; van den Berge M; Faiz A, 2019. Gene network approach reveals co-expression patterns in nasal and bronchial epithelium. Sci Rep 9(1):15835
Carpaij OA; Burgess JK; Kerstjens HAM; Nawijn MC; van den Berge M, 2019. A review on the pathophysiology of asthma remission. Pharmacol Ther 201:8-24
Xu CJ; Söderhäll C; Bustamante M; Baïz N; Gruzieva O; Gehring U; Mason D; Chatzi L; Basterrechea M; Llop S; Torrent M; Forastiere F; Fantini MP; Carlsen KCL; Haahtela T; Morin A; Kerkhof M; Merid SK; van Rijkom B; Jankipersadsing SA; Bonder MJ; Ballereau S; Vermeulen CJ; Aguirre-Gamboa R; de Jongste JC; Smit HA; Kumar A; Pershagen G; Guerra S; Garcia-Aymerich J; Greco D; Reinius L; McEachan RRC; Azad R; Hovland V; Mowinckel P; Alenius H; Fyhrquist N; Lemonnier N; Pellet J; Auffray C; van der Vlies P; van Diemen CC; Li Y; Wijmenga C; Netea MG; Moffatt MF; Cookson WOCM; Anto JM; Bousquet J; Laatikainen T; Laprise C; Carlsen KH; Gori D; Porta D; Iñiguez C; Bilbao JR; Kogevinas M; Wright J; Brunekreef B; Kere J; Nawijn MC; Annesi-Maesano I; Sunyer J; Melén E; Koppelman GH, 2018. DNA methylation in childhood asthma: an epigenome-wide meta-analysis. Lancet Respir Med 6(5):379-388
Dijk FN; Xu C; Melén E; Carsin AE; Kumar A; Nolte IM; Gruzieva O; Pershagen G; Grotenboer NS; Savenije OEM; Antó JM; Lavi I; Dobaño C; Bousquet J; van der Vlies P; van der Valk RJP; de Jongste JC; Nawijn MC; Guerra S; Postma DS; Koppelman GH, 2018. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma. Eur Respir J 51.
Jaffar J; Yang SH; Kim SY; Kim HW; Faiz A; Chrzanowski W; Burgess JK, 2018. Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 315(1):L59-L65
Wang J; Faiz A; Ge Q; Vermeulen CJ; Van der Velden J; Snibson KJ; van de Velde R; Sawant S; Xenaki D; Oliver B; Timens W; Ten Hacken N; van den Berge M; James A; Elliot JG; Dong L; Burgess JK; Ashton AW, 2018. Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling. J Cell Mol Med 22(5):2826-2837
Aghapour M; Raee P; Moghaddam SJ; Hiemstra PS; Heijink IH, 2018. Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure. Am J Respir Cell Mol Biol 58(2):157-169
van den Berge M; Jonker MR; Miller-Larsson A; Postma DS; Heijink IH, 2018. Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells. Pulm Pharmacol Ther 50:47-56
Burgess JK; Ketheson A; Faiz A; Limbert Rempel KA; Oliver BG; Ward JPT; Halayko AJ, 2018. Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors. Sci Rep 8(1):805
Hesse L; van Ieperen N; Habraken C; Petersen AH; Korn S; Smilda T; Goedewaagen B; Ruiters MH; van der Graaf AC; Nawijn MC, 2018. Subcutaneous immunotherapy with purified Der p1 and 2 suppresses type 2 immunity in a murine asthma model. Allergy 73(4):862-874
Terlizzi V; Kolibabka M; Burgess JK; Hammes HP; Harmsen MC, 2018. The Pericytic Phenotype of Adipose Tissue-Derived Stromal Cells Is Promoted by NOTCH2. Stem Cells 36(2):240-251
Imkamp K; Berg M; Vermeulen CJ; Heijink IH; Guryev V; Kerstjens HAM; Koppelman GH; van den Berge M; Faiz A, 2018. Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci. J Allergy Clin Immunol 142(1):314-317.e15
Di Vincenzo S; Heijink IH; Noordhoek JA; Cipollina C; Siena L; Bruno A; Ferraro M; Postma DS; Gjomarkaj M; Pace E, 2018. SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells. J Cell Mol Med 22(4):2272-2282
Waters DW; Blokland KEC; Pathinayake PS; Burgess JK; Mutsaers SE; Prele CM; Schuliga M; Grainge CL; Knight DA, 2018. Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 315(2):L162-L172
Tasena H; Faiz A; Timens W; Noordhoek J; Hylkema MN; Gosens R; Hiemstra PS; Spira A; Postma DS; Tew GW; Grimbaldeston MA; van den Berge M; Heijink IH; Brandsma CA, 2018. microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD. Eur Respir J 52.
Schuliga M; Pechkovsky DV; Read J; Waters DW; Blokland KEC; Reid AT; Hogaboam CM; Khalil N; Burgess JK; Prêle CM; Mutsaers SE; Jaffar J; Westall G; Grainge C; Knight DA, 2018. Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts. J Cell Mol Med 22(12):5847-5861
Ng-Blichfeldt JP; Schrik A; Kortekaas RK; Noordhoek JA; Heijink IH; Hiemstra PS; Stolk J; Königshoff M; Gosens R, 2018. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine 36:461-474
Kruk DMLW; Heijink IH; Slebos DJ; Timens W; Ten Hacken NH, 2018. Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon? Respiration 96(2):148-158
Faiz A; Heijink IH; Vermeulen CJ; Guryev V; van den Berge M; Nawijn MC; Pouwels SD, 2018. Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release. Sci Rep 8(1):12426
Post S; Heijink IH; Hesse L; Koo HK; Shaheen F; Fouadi M; Kuchibhotla VNS; Lambrecht BN; Van Oosterhout AJM; Hackett TL; Nawijn MC, 2018. Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology. Sci Rep 8(1):13275
Nissen G; Hollaender H; Tang FSM; Wegmann M; Lunding L; Vock C; Bachmann A; Lemmel S; Bartels R; Oliver BG; Burgess JK; Becker T; Kopp MV; Weckmann M, 2018. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy 48(11):1483-1493
Faiz A; Weckmann M; Tasena H; Vermeulen CJ; Van den Berge M; Ten Hacken NHT; Halayko AJ; Ward JPT; Lee TH; Tjin G; Black JL; Haghi M; Xu CJ; King GG; Farah CS; Oliver BG; Heijink IH; Burgess JK, 2018. Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion. Eur Respir J 52.
Billatos E; Faiz A; Gesthalter Y; LeClerc A; Alekseyev YO; Xiao X; Liu G; Ten Hacken NHT; Heijink IH; Timens W; Brandsma CA; Postma DS; van den Berge M; Spira A; Lenburg ME, 2018. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics 50(9):705-713
Carpaij OA; Muntinghe FOW; Wagenaar MB; Habing JW; Timens W; Kerstjens HAM; Nawijn MC; Kunz LIZ; Hiemstra PS; Tew GW; Holweg CTJ; Brandsma CA; van den Berge M, 2018. Serum periostin does not reflect type 2-driven inflammation in COPD. Respir Res 19(1):112
Hesse L; Brouwer U; Petersen AH; Gras R; Bosman L; Brimnes J; Oude Elberink JNG; van Oosterhout AJM; Nawijn MC, 2018. Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma. Clin Exp Allergy 48(8):1035-1049
Osei ET; Florez-Sampedro L; Tasena H; Faiz A; Noordhoek JA; Timens W; Postma DS; Hackett TL; Heijink IH; Brandsma CA, 2017. miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD. Eur Respir J 49.
Faiz A; Donovan C; Nieuwenhuis MA; van den Berge M; Postma DS; Yao S; Park CY; Hirsch R; Fredberg JJ; Tjin G; Halayko AJ; Rempel KL; Ward JP; Lee T; Bossé Y; Nickle DC; Obeidat M; Vonk JM; Black JL; Oliver BG; Krishnan R; McParland B; Bourke JE; Burgess JK, 2017. Latrophilin receptors: novel bronchodilator targets in asthma. Thorax 72(1):74-82
Pouwels SD; van Geffen WH; Jonker MR; Kerstjens HA; Nawijn MC; Heijink IH, 2017. Increased neutrophil expression of pattern recognition receptors during COPD exacerbations. Respirology 22(2):401-404
Hesse L; Nawijn MC, 2017. Subcutaneous and Sublingual Immunotherapy in a Mouse Model of Allergic Asthma. Methods Mol Biol 1559:137-168
Anto JM; Bousquet J; Akdis M; Auffray C; Keil T; Momas I; Postma DS; Valenta R; Wickman M; Cambon-Thomsen A; Haahtela T; Lambrecht BN; Lodrup Carlsen KC; Koppelman GH; Sunyer J; Zuberbier T; Annesi-Maesano I; Arno A; Bindslev-Jensen C; De Carlo G; Forastiere F; Heinrich J; Kowalski ML; Maier D; Melén E; Smit HA; Standl M; Wright J; Asarnoj A; Benet M; Ballardini N; Garcia-Aymerich J; Gehring U; Guerra S; Hohmann C; Kull I; Lupinek C; Pinart M; Skrindo I; Westman M; Smagghe D; Akdis C; Andersson N; Bachert C; Ballereau S; Ballester F; Basagana X; Bedbrook A; Bergstrom A; von Berg A; Brunekreef B; Burte E; Carlsen KH; Chatzi L; Coquet JM; Curin M; Demoly P; Eller E; Fantini MP; von Hertzen L; Hovland V; Jacquemin B; Just J; Keller T; Kiss R; Kogevinas M; Koletzko S; Lau S; Lehmann I; Lemonnier N; Mäkelä M; Mestres J; Mowinckel P; Nadif R; Nawijn MC; Pellet J; Pin I; Porta D; Rancière F; Rial-Sebbag E; Saeys Y; Schuijs MJ; Siroux V; Tischer CG; Torrent M; Varraso R; Wenzel K; Xu CJ, 2017. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol 139(2):388-399
Ketelaar ME; van de Kant KD; Dijk FN; Klaassen EM; Grotenboer NS; Nawijn MC; Dompeling E; Koppelman GH, 2017. Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO. Allergy 72(11):1811-1815
Song J; Heijink IH; Kistemaker LEM; Reinders-Luinge M; Kooistra W; Noordhoek JA; Gosens R; Brandsma CA; Timens W; Hiemstra PS; Rots MG; Hylkema MN, 2017. Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD. Clin Epigenetics 9:42
Song J; Cano-Rodriquez D; Winkle M; Gjaltema RA; Goubert D; Jurkowski TP; Heijink IH; Rots MG; Hylkema MN, 2017. Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 312(3):L334-L347
Pouwels SD; Faiz A; den Boef LE; Gras R; van den Berge M; Boezen HM; Korstanje R; Ten Hacken NHT; van Oosterhout AJM; Heijink IH; Nawijn MC, 2017. Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice. Am J Physiol Lung Cell Mol Physiol 313(3):L559-L580
Aguilar D; Pinart M; Koppelman GH; Saeys Y; Nawijn MC; Postma DS; Akdis M; Auffray C; Ballereau S; Benet M; García-Aymerich J; González JR; Guerra S; Keil T; Kogevinas M; Lambrecht B; Lemonnier N; Melen E; Sunyer J; Valenta R; Valverde S; Wickman M; Bousquet J; Oliva B; Antó JM, 2017. Computational analysis of multimorbidity between asthma, eczema and rhinitis. PLoS One 12(6):e0179125
Harkness LM; Weckmann M; Kopp M; Becker T; Ashton AW; Burgess JK, 2017. Tumstatin regulates the angiogenic and inflammatory potential of airway smooth muscle extracellular matrix. J Cell Mol Med 21(12):3288-3297
van Gisbergen MW; Voets AM; Biemans R; Hoffmann RF; Drittij-Reijnders MJ; Haenen GRMM; Heijink IH; Rouschop KMA; Dubois LJ; Lambin P, 2017. Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress. PLoS One 12(8):e0182508
Liu G; Cooley MA; Nair PM; Donovan C; Hsu AC; Jarnicki AG; Haw TJ; Hansbro NG; Ge Q; Brown AC; Tay H; Foster PS; Wark PA; Horvat JC; Bourke JE; Grainge CL; Argraves WS; Oliver BG; Knight DA; Burgess JK; Hansbro PM, 2017. Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c. J Pathol 243(4):510-523
Boudewijn IM; Faiz A; Steiling K; van der Wiel E; Telenga ED; Hoonhorst SJM; Ten Hacken NHT; Brandsma CA; Kerstjens HAM; Timens W; Heijink IH; Jonker MR; de Bruin HG; Sebastiaan Vroegop J; Pasma HR; Boersma WG; Wielders P; van den Elshout F; Mansour K; Spira A; Lenburg ME; Guryev V; Postma DS; van den Berge M, 2017. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respir Res 18(1):213
Murtha LA; Schuliga MJ; Mabotuwana NS; Hardy SA; Waters DW; Burgess JK; Knight DA; Boyle AJ, 2017. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis. Front Physiol 8:777
Tjin G; White ES; Faiz A; Sicard D; Tschumperlin DJ; Mahar A; Kable EPW; Burgess JK, 2017. Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis. Dis Model Mech 10(11):1301-1312
Pouwels SD; Zijlstra GJ; van der Toorn M; Hesse L; Gras R; Ten Hacken NH; Krysko DV; Vandenabeele P; de Vries M; van Oosterhout AJ; Heijink IH; Nawijn MC, 2016. Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol 310(4):L377-86
Heijink IH; Jonker MR; de Vries M; van Oosterhout AJ; Telenga E; Ten Hacken NH; Postma DS; van den Berge M, 2016. Budesonide and fluticasone propionate differentially affect the airway epithelial barrier. Respir Res 17:2
Spanjer AI; Menzen MH; Dijkstra AE; van den Berge M; Boezen HM; Nickle DC; Sin DD; Bossé Y; Brandsma CA; Timens W; Postma DS; Meurs H; Heijink IH; Gosens R, 2016. A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis. Thorax 71(4):312-22
Spanjer AI; Baarsma HA; Oostenbrink LM; Jansen SR; Kuipers CC; Lindner M; Postma DS; Meurs H; Heijink IH; Gosens R; Königshoff M, 2016. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J 30(5):1823-35
Ketelaar ME; Nawijn MC; Shaw DE; Koppelman GH; Sayers I, 2016. The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma. Clin Exp Allergy 46(6):884-7
Vries Md; Bedke N; Smithers NP; Loxham M; Howarth PH; Nawijn MC; Davies DE, 2016. Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations. Eur Respir J 47(3):783-91
Heijink IH; de Bruin HG; Dennebos R; Jonker MR; Noordhoek JA; Brandsma CA; van den Berge M; Postma DS, 2016. Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD. Eur Respir J 48(2):504-15
Van der Velden J; Harkness LM; Barker DM; Barcham GJ; Ugalde CL; Koumoundouros E; Bao H; Organ LA; Tokanovic A; Burgess JK; Snibson KJ, 2016. The Effects of Tumstatin on Vascularity, Airway Inflammation and Lung Function in an Experimental Sheep Model of Chronic Asthma. Sci Rep 6:26309
Kim SY; Burgess JK; Wang Y; Kable EP; Weiss DJ; Chan HK; Chrzanowski W, 2016. Atomized Human Amniotic Mesenchymal Stromal Cells for Direct Delivery to the Airway for Treatment of Lung Injury. J Aerosol Med Pulm Drug Deliv 29(6):514-524
Tang FS; Hansbro PM; Burgess JK; Ammit AJ; Baines KJ; Oliver BG, 2016. A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro. Thorax 71(11):1039-1049
Liu G; Cooley MA; Jarnicki AG; Hsu AC; Nair PM; Haw TJ; Fricker M; Gellatly SL; Kim RY; Inman MD; Tjin G; Wark PA; Walker MM; Horvat JC; Oliver BG; Argraves WS; Knight DA; Burgess JK; Hansbro PM, 2016. Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight 1.
Osei ET; Noordhoek JA; Hackett TL; Spanjer AI; Postma DS; Timens W; Brandsma CA; Heijink IH, 2016. Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD. Eur Respir J 48(2):359-69
Faura Tellez G; Willemse BW; Brouwer U; Nijboer-Brinksma S; Vandepoele K; Noordhoek JA; Heijink I; de Vries M; Smithers NP; Postma DS; Timens W; Wiffen L; van Roy F; Holloway JW; Lackie PM; Nawijn MC; Koppelman GH, 2016. Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma. PLoS One 11(10):e0163967
Burgess JK; Mauad T; Tjin G; Karlsson JC; Westergren-Thorsson G, 2016. The extracellular matrix - the under-recognized element in lung disease? J Pathol 240(4):397-409
Pouwels SD; Hesse L; Faiz A; Lubbers J; Bodha PK; Ten Hacken NH; van Oosterhout AJ; Nawijn MC; Heijink IH, 2016. Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD. Am J Physiol Lung Cell Mol Physiol 311(5):L881-L892
Schwarze J; Fitch PM; Heimweg J; Errington C; Matsuda R; de Bruin HG; van den Berge M; van Oosterhout AJ; Heijink IH, 2016. Viral mimic poly-(I:C) attenuates airway epithelial T-cell suppressive capacity: implications for asthma. Eur Respir J 48(6):1785-1788
Saluja R; Ketelaar ME; Hawro T; Church MK; Maurer M; Nawijn MC, 2015. The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders. Mol Immunol 63(1):80-5
Bidad K; Nawijn MC; van Oosterhout AJ; van der Heide S; Oude Elberink JN, 2015. Basophil activation test in mastocytosis patients with and without wasp venom allergy. Cytometry B Clin Cytom 88(1):5
Matusiak N; van Waarde A; Rozeveld D; van Oosterhout AJ; Heijink IH; Castelli R; Overkleeft HS; Bischoff R; Dierckx RA; Elsinga PH, 2015. MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation. Mol Imaging Biol 17(5):680-7
Poppinga WJ; Heijink IH; Holtzer LJ; Skroblin P; Klussmann E; Halayko AJ; Timens W; Maarsingh H; Schmidt M, 2015. A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 308(8):L766-75
Heijink IH; Rozeveld D; van der Heide S; van der Bij W; Bischoff R; van Oosterhout AJ; van der Toorn M, 2015. Metalloproteinase Profiling in Lung Transplant Recipients With Good Outcome and Bronchiolitis Obliterans Syndrome. Transplantation 99(9):1946-52
de Vries M; Smithers NP; Howarth PH; Nawijn MC; Davies DE, 2015. Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells. Eur Respir J 45(6):1745-8
Pouwels SD; Heijink IH; Brouwer U; Gras R; den Boef LE; Boezen HM; Korstanje R; van Oosterhout AJ; Nawijn MC, 2015. Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice. Am J Physiol Lung Cell Mol Physiol 308(7):L693-709
Pouwels SD; Nawijn MC; Bathoorn E; Riezebos-Brilman A; van Oosterhout AJ; Kerstjens HA; Heijink IH, 2015. Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients. Eur Respir J 45(5):1482-5
Osei ET; Florez-Sampedro L; Timens W; Postma DS; Heijink IH; Brandsma CA, 2015. Unravelling the complexity of COPD by microRNAs: it's a small world after all. Eur Respir J 46(3):807-18
Post S; Rozeveld D; Jonker MR; Bischoff R; van Oosterhout AJ; Heijink IH, 2015. ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium. Allergy 70(12):1545-52
Ngkelo A; Hoffmann RF; Durham AL; Marwick JA; Brandenburg SM; de Bruin HG; Jonker MR; Rossios C; Tsitsiou E; Caramori G; Contoli M; Casolari P; Monaco F; Andò F; Speciale G; Kilty I; Chung KF; Papi A; Lindsay MA; Ten Hacken NH; van den Berge M; Timens W; Barnes PJ; van Oosterhout AJ; Adcock IM; Kirkham PA; Heijink IH, 2015. Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD. Am J Physiol Lung Cell Mol Physiol 309(10):L1112-23
Faura Tellez G; Vandepoele K; Brouwer U; Koning H; Elderman RM; Hackett TL; Willemse BW; Holloway J; Van Roy F; Koppelman GH; Nawijn MC, 2015. Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription. Am J Physiol Lung Cell Mol Physiol 309(7):L725-35
de Vries M; Hesse L; Jonker MR; van den Berge M; van Oosterhout AJ; Heijink IH; Nawijn MC, 2015. Pim1 kinase activity preserves airway epithelial integrity upon house dust mite exposure. Am J Physiol Lung Cell Mol Physiol 309(11):L1344-53
Tang FS; Foxley GJ; Gibson PG; Burgess JK; Baines KJ; Oliver BG, 2015. Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma. Mediators Inflamm 2015:219374
Zijlstra GJ; Fattahi F; Rozeveld D; Jonker MR; Kliphuis NM; van den Berge M; Hylkema MN; ten Hacken NH; van Oosterhout AJ; Heijink IH, 2014. Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium. Eur Respir J 44(2):361-70
Pouwels SD; Heijink IH; ten Hacken NH; Vandenabeele P; Krysko DV; Nawijn MC; van Oosterhout AJ, 2014. DAMPs activating innate and adaptive immune responses in COPD. Mucosal Immunol 7(2):215-26
Pouwels SD; Heijink IH; van Oosterhout AJ; Nawijn MC, 2014. A specific DAMP profile identifies susceptibility to smoke-induced airway inflammation. Eur Respir J 43(4):1183-6
Oldenburger A; Poppinga WJ; Kos F; de Bruin HG; Rijks WF; Heijink IH; Timens W; Meurs H; Maarsingh H; Schmidt M, 2014. A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. Am J Physiol Cell Physiol 306(6):C585-97
Bidad K; Nawijn MC; van Oosterhout AJ; van der Heide S; Elberink JN, 2014. Basophil activation test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy on immunotherapy. Cytometry B Clin Cytom 86(3):183-90
Faura Tellez G; Nawijn MC; Koppelman GH, 2014. Protocadherin-1: Epithelial barrier dysfunction in asthma and eczema. Eur Respir J 43(3):671-4
Heijink IH; Nawijn MC; Hackett TL, 2014. Airway epithelial barrier function regulates the pathogenesis of allergic asthma. Clin Exp Allergy 44(5):620-30
Dijkstra AE; Smolonska J; van den Berge M; Wijmenga C; Zanen P; Luinge MA; Platteel M; Lammers JW; Dahlback M; Tosh K; Hiemstra PS; Sterk PJ; Spira A; Vestbo J; Nordestgaard BG; Benn M; Nielsen SF; Dahl M; Verschuren WM; Picavet HS; Smit HA; Owsijewitsch M; Kauczor HU; de Koning HJ; Nizankowska-Mogilnicka E; Mejza F; Nastalek P; van Diemen CC; Cho MH; Silverman EK; Crapo JD; Beaty TH; Lomas DA; Bakke P; Gulsvik A; Bossé Y; Obeidat M; Loth DW; Lahousse L; Rivadeneira F; Uitterlinden AG; Hofman A; Stricker BH; Brusselle GG; van Duijn CM; Brouwer U; Koppelman GH; Vonk JM; Nawijn MC; Groen HJ; Timens W; Boezen HM; Postma DS, 2014. Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS One 9(4):e91621
Post S; Heijink IH; Petersen AH; de Bruin HG; van Oosterhout AJ; Nawijn MC, 2014. Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice. PLoS One 9(3):e91206
de Vries M; Heijink IH; Gras R; den Boef LE; Reinders-Luinge M; Pouwels SD; Hylkema MN; van der Toorn M; Brouwer U; van Oosterhout AJ; Nawijn MC, 2014. Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation. Am J Physiol Lung Cell Mol Physiol 307(3):L240-51
Heijink IH; Noordhoek JA; Timens W; van Oosterhout AJ; Postma DS, 2014. Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 189(11):1439-42
Chen L; Ge Q; Tjin G; Alkhouri H; Deng L; Brandsma CA; Adcock I; Timens W; Postma D; Burgess JK; Black JL; Oliver BG, 2014. Effects of cigarette smoke extract on human airway smooth muscle cells in COPD. Eur Respir J 44(3):634-46
Koning H; van Oosterhout AJ; Brouwer U; den Boef LE; Gras R; Reinders-Luinge M; Brandsma CA; van der Toorn M; Hylkema MN; Willemse BW; Sayers I; Koppelman GH; Nawijn MC, 2014. Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo. PLoS One 9(7):e98197
Burgess JK; Gosens R, 2014. Airway Smooth Muscle and Fibroblast Biology still a leading research focus for Young Investigators in the field. Pulm Pharmacol Ther 29(2):91-2
Boorsma CE; Dekkers BG; van Dijk EM; Kumawat K; Richardson J; Burgess JK; John AE, 2014. Beyond TGFβ--novel ways to target airway and parenchymal fibrosis. Pulm Pharmacol Ther 29(2):166-80
van den Berge M; Steiling K; Timens W; Hiemstra PS; Sterk PJ; Heijink IH; Liu G; Alekseyev YO; Lenburg ME; Spira A; Postma DS, 2014. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax 69(1):14-23
Kistemaker LE; Bos IS; Hylkema MN; Nawijn MC; Hiemstra PS; Wess J; Meurs H; Kerstjens HA; Gosens R, 2013. Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice. Eur Respir J 42(6):1677-88
Heijink IH; de Bruin HG; van den Berge M; Bennink LJ; Brandenburg SM; Gosens R; van Oosterhout AJ; Postma DS, 2013. Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease. Thorax 68(8):709-16
Nawijn MC; Motta AC; Gras R; Shirinbak S; Maazi H; van Oosterhout AJ, 2013. TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice. PLoS One 8(2):e55307
Grotenboer NS; Ketelaar ME; Koppelman GH; Nawijn MC, 2013. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. J Allergy Clin Immunol 131(3):856-65
Maazi H; Shirinbak S; den Boef LE; Fallarino F; Volpi C; Nawijn MC; van Oosterhout AJ, 2013. Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy. Clin Exp Immunol 172(1):113-20
Heijink IH; van den Berge M, 2013. Are salmeterol's beneficial effects on corticosteroid action in the airways executed at the epithelial barrier? Respirology 18(8):1165-6
Hoffmann RF; Zarrintan S; Brandenburg SM; Kol A; de Bruin HG; Jafari S; Dijk F; Kalicharan D; Kelders M; Gosker HR; Ten Hacken NH; van der Want JJ; van Oosterhout AJ; Heijink IH, 2013. Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. Respir Res 14:97
Bidad K; Nawijn MC; van Oosterhout AJ; van der Heide S; Elberink JN, 2013. Basophil Activation Test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy. Cytometry B Clin Cytom.
Post S; Nawijn MC; Jonker MR; Kliphuis N; van den Berge M; van Oosterhout AJ; Heijink IH, 2013. House dust mite-induced calcium signaling instigates epithelial barrier dysfunction and CCL20 production. Allergy 68(9):1117-25
Heijink IH; Brandenburg SM; Postma DS; van Oosterhout AJ, 2012. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 39(2):419-28
Maazi H; Shirinbak S; Willart M; Hammad HM; Cabanski M; Boon L; Ganesh V; Baru AM; Hansen G; Lambrecht BN; Sparwasser T; Nawijn MC; van Oosterhout AJ, 2012. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy. Clin Exp Allergy 42(10):1519-28
Post S; Nawijn MC; Hackett TL; Baranowska M; Gras R; van Oosterhout AJ; Heijink IH, 2012. The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation. Thorax 67(6):488-95
Koning H; Sayers I; Stewart CE; de Jong D; Ten Hacken NH; Postma DS; van Oosterhout AJ; Nawijn MC; Koppelman GH, 2012. Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation. FASEB J 26(1):439-48
Zijlstra GJ; Ten Hacken NH; Hoffmann RF; van Oosterhout AJ; Heijink IH, 2012. Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells. Eur Respir J 39(2):439-45
Nawijn MC; Alendar A; Berns A, 2011. For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer 11(1):23-34
Nawijn MC; Hackett TL; Postma DS; van Oosterhout AJ; Heijink IH, 2011. E-cadherin: gatekeeper of airway mucosa and allergic sensitization. Trends Immunol 32(6):248-55
Nawijn MC; Piavaux BJ; Jeurink PV; Gras R; Reinders MA; Stearns T; Foote S; Hylkema MN; Groot PC; Korstanje R; Oosterhout AJ, 2011. Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice. Am J Respir Cell Mol Biol 45(2):295-303
Van Hemelen D; Oude Elberink JN; Bohle B; Heimweg J; Nawijn MC; van Oosterhout AJ, 2011. Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures. J Immunol Methods 371(1-2):114-21
Koppelman GH; Nawijn MC, 2011. Recent advances in the epigenetics and genomics of asthma. Curr Opin Allergy Clin Immunol 11(5):414-9
Heijink IH; Brandenburg SM; Noordhoek JA; Slebos DJ; Postma DS; van Oosterhout AJ, 2011. Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD. Respir Res 12:110
Maazi H; Shirinbak S; Bloksma N; Nawijn MC; van Oosterhout AJ, 2011. Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma. Clin Exp Immunol 166(1):80-6
Shirinbak S; Taher YA; Maazi H; Gras R; van Esch BC; Henricks PA; Samsom JN; Verbeek JS; Lambrecht BN; van Oosterhout AJ; Nawijn MC, 2010. Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice. J Immunol 185(7):3857-65
Heijink IH; van Oosterhout A; Kapus A, 2010. Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction. Eur Respir J 36(5):1016-26
Gosens R; Baarsma HA; Heijink IH; Oenema TA; Halayko AJ; Meurs H; Schmidt M, 2010. De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth. FASEB J 24(3):757-68
Heijink IH; Brandenburg SM; Noordhoek JA; Postma DS; Slebos DJ; van Oosterhout AJ, 2010. Characterisation of cell adhesion in airway epithelial cell types using electric cell-substrate impedance sensing. Eur Respir J 35(4):894-903
Heijink IH; Postma DS; Noordhoek JA; Broekema M; Kapus A, 2010. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. Am J Respir Cell Mol Biol 42(1):69-79
Motta AC; Vissers JL; Gras R; Van Esch BC; Van Oosterhout AJ; Nawijn MC, 2009. GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma. Respir Res 10:93
Heijink IH; Kauffman HF; Vellenga E; Veltman-Starkenburg CA; Postma DS; de Monchy JG, 2008. Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma. Int Arch Allergy Immunol 145(2):111-21
Heijink IH; Kies PM; Kauffman HF; Postma DS; van Oosterhout AJ; Vellenga E, 2007. Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity. J Immunol 178(12):7678-85
Heijink IH; Marcel Kies P; van Oosterhout AJ; Postma DS; Kauffman HF; Vellenga E, 2007. Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium. Am J Respir Cell Mol Biol 36(3):351-9
Heijink IH; Van Oosterhout AJ, 2006. Strategies for targeting T-cells in allergic diseases and asthma. Pharmacol Ther 112(2):489-500
Heijink IH; Van Oosterhout AJ, 2005. Targeting T cells for asthma. Curr Opin Pharmacol 5(3):227-31
Heijink IH; Vellenga E; Oostendorp J; de Monchy JG; Postma DS; Kauffman HF, 2005. Exposure to TARC alters beta2-adrenergic receptor signaling in human peripheral blood T lymphocytes. Am J Physiol Lung Cell Mol Physiol 289(1):L53-9
Heijink IH; van den Berge M; Vellenga E; de Monchy JG; Postma DS; Kauffman HF, 2004. Altered beta2-adrenergic regulation of T cell activity after allergen challenge in asthma. Clin Exp Allergy 34(9):1356-63
Heijink IH; Kauffman HF; Postma DS; de Monchy JG; Vellenga E, 2003. Sensitivity of IL-5 production to the cAMP-dependent pathway in human T cells is reduced by exogenous IL-2 in a phosphoinositide 3-kinase-dependent way. Eur J Immunol 33(8):2206-15
Heijink IH; Vellenga E; Borger P; Postma DS; Monchy JG; Kauffman HF, 2003. Polarized Th1 and Th2 cells are less responsive to negative feedback by receptors coupled to the AC/cAMP system compared to freshly isolated T cells. Br J Pharmacol 138(8):1441-50
Heijink IH; Vellenga E; Borger P; Postma DS; de Monchy JG; Kauffman HF, 2002. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells. Immunology 107(3):316-24
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